G. Tyzack

发表

Meta-analysis of the amyotrophic lateral sclerosis spectrum uncovers genome instability

O. Ziff, S. Boulton, J. Humphrey, 2022, medRxiv.

Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS

Christopher R. Sibley, J. Ule, N. Luscombe, 2017, Cell reports.

Automated and unbiased classification of motor neuron phenotypes with single cell resolution in ALS tissue

L. Greensmith, J. Newcombe, Raphaëlle Luisier, 2020, bioRxiv.

Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS

N. Luscombe, J. Newcombe, Raphaëlle Luisier, 2020, Brain : a journal of neurology.

Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS

J. Ule, N. Luscombe, L. Greensmith, 2018, Nature Communications.

Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis

N. Luscombe, O. Ziff, Raphaëlle Luisier, 2021, Brain : a journal of neurology.

Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in amyotrophic lateral sclerosis

Doaa, N. Luscombe, O. Ziff, 2021 .

Reactive astrocytes in ALS display diminished intron retention

N. Luscombe, O. Ziff, G. Kelly, 2021, Nucleic acids research.

Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis

Christopher R. Sibley, O. Ziff, B. Kalmar, 2022, Brain : a journal of neurology.

Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis

J. Collinge, Yun-Ru Chen, J. Newcombe, 2020, Brain : a journal of neurology.

Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression

James W. Fawcett, Robin J. M. Franklin, Chao Zhao, 2014, Nature Communications.

The FUS gene is dual‐coding with both proteins contributing to FUS‐mediated toxicity

M. Brunet, Jean-François Jacques, X. Roucou, 2020, EMBO reports.

An aberrant cytoplasmic intron retention programme is a blueprint for ALS-related RBP mislocalization

N. Luscombe, O. Ziff, H. Crerar, 2020, bioRxiv.

FUS gene is dual-coding with both proteins united in FUS-mediated toxicity

M. Brunet, Jean-François Jacques, X. Roucou, 2019 .

FUS gene is dual-coding with both proteins united in molecular hallmarks of amyotrophic lateral sclerosis

M. Brunet, Jean-François Jacques, X. Roucou, 2019, bioRxiv.

Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis

J. Ule, N. Luscombe, L. Greensmith, 2019, Brain : a journal of neurology.

Widespread FUS mislocalization is a molecular hallmark of ALS

J. Ule, N. Luscombe, L. Greensmith, 2019, bioRxiv.

Post-transcriptional remodelling is temporally deregulated during motor neurogenesis in human ALS models

J. Ule, N. Luscombe, Raphaëlle Luisier, 2017, bioRxiv.

Physiological intron retaining transcripts in the cytoplasm abound during human motor neurogenesis

Raphaëlle Luisier, H. Crerar, R. Patani, 2022, Genome research.

Diminished miRNA activity is associated with aberrant cytoplasmic intron retention in ALS pathogenesis

Raphaëlle Luisier, H. Crerar, R. Patani, 2021, bioRxiv.

Viral Manipulation of Neural Stem/Precursor Cells

S. Pluchino, C. Cossetti, C. Alfaro-Cervelló, 2014 .

Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering

M. Duchen, O. Cappellari, D. Wells, 2018, Cell reports.

Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength

Kevin W. Kelley, D. Rowitch, E. Ullian, 2018, Neuron.

Human Stem Cell-Derived Astrocytes: Specification and Relevance for Neurological Disorders

A. Lakatos, R. Patani, G. Tyzack, 2016, Current Stem Cell Reports.

New perspectives of tissue remodelling with neural stem and progenitor cell-based therapies

S. Pluchino, C. Cossetti, Chiara Cossetti, 2012, Cell and Tissue Research.

A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models

Christopher R. Sibley, J. Newcombe, G. Schiavo, 2017, Nature Communications.

SPACE exploration of chromatin proteome to reveal associated RNA-binding proteins

J. Ule, N. Luscombe, M. Rafiee, 2020 .

Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS

J. Ule, N. Luscombe, L. Greensmith, 2018, Nature Communications.

Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology

A. Al-Chalabi, O. Ziff, S. Boulton, 2023, Nature communications.

New perspectives of tissue remodelling with neural stem and progenitor cell-based therapies

S. Pluchino, C. Cossetti, C. Alfaro-Cervelló, 2012, Cell and Tissue Research.

“Axonal Length Determines distinct homeostatic phenotypes in human iPSC derived motor neurons on a bioengineered platform”

C. Chiappini, A. Serio, R. Patani, 2021, bioRxiv.

Regionally encoded functional heterogeneity of astrocytes in health and disease: A perspective

R. Patani, Giulia E. Tyzack, Doaa M. Taha, 2020, Glia.

Delineating Astrocytic Cytokine Responses in a Human Stem Cell Model of Neural Trauma

A. Frostell, E. Thelin, A. Helmy, 2019, Journal of neurotrauma.

Automated and unbiased discrimination of ALS from control tissue at single cell resolution

L. Greensmith, J. Newcombe, Raphaëlle Luisier, 2021, Brain pathology.

Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition

O. Ziff, M. Skehel, R. Patani, 2023, Neuron.