N. Brooks

发表

Alteration in the choice of DNA repair pathway with increasing sequence selective DNA alkylation in the minor groove.

P. McHugh, M. Lee, J. Hartley, 2000, Chemistry & biology.

Design, Synthesis, and Evaluation of a Novel Pyrrolobenzodiazepine DNA‐Interactive Agent with Highly Efficient Cross‐Linking Ability and Potent Cytotoxicity.

L. Kèlland, J. Hartley, T. C. Jenkins, 2001 .

Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.

L. Kèlland, J. Hartley, T. C. Jenkins, 2001, Journal of medicinal chemistry.

SJG-136 (NSC 694501), a Novel Rationally Designed DNA Minor Groove Interstrand Cross-Linking Agent with Potent and Broad Spectrum Antitumor Activity

E. Sausville, P. McHugh, L. Kèlland, 2004, Cancer Research.

EFFICIENT SYNTHESIS OF (±)-seco-CYCLOPROPANEINDOLINE ANALOGS OF CC-1065

J. Hartley, S. Roller, P. Burke, 2001 .

Design, synthesis, and biological evaluation of achiral analogs of duocarmycin SA.

Erik C. Madsen, J. Hartley, H. Handl, 2005, Bioorganic & medicinal chemistry letters.

Structure-activity relationship of a series of C-terminus modified aminoalkyl, diaminoalkyl- and anilino-containing analogues of the benzoic acid mustard distamycin derivative tallimustine: synthesis, DNA binding and cytotoxicity studies.

M. D. Fontaine, J. Hartley, M. Lee, 1997, Bioorganic & medicinal chemistry.

Novel platinum(II) derivatives of analogues of netropsin and distamycin: Synthesis, DNA binding and cytotoxic properties

L. Kèlland, J. Hartley, Moses Lee, 1996 .

Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.

J. Hartley, T. C. Jenkins, P. Howard, 2004, Journal of medicinal chemistry.

The role of base excision repair in the repair of DNA adducts formed by a series of nitrogen mustard-containing analogues of distamycin of increasing binding site size.

P. McHugh, M. Lee, J. Hartley, 1999, Anti-cancer drug design.