Hirobumi Takahashi

发表

Discovery of tetrasubstituted imidazolines as potent and selective neuropeptide Y Y5 receptor antagonists: reduced human ether-a-go-go related gene potassium channel binding affinity and potent antiobesity effect.

H. Iwaasa, M. Ando, T. Ohe, 2009, Journal of medicinal chemistry.

Discovery of novel arylpyrazole series as potent and selective opioid receptor-like 1 (ORL1) antagonists.

S. Ozaki, Y. Ishii, Yasushi Nagatomi, 2009, Bioorganic & medicinal chemistry letters.

A convenient synthetic method of a 5,7-diarylcyclopenteno-[1,2-b]pyridine-6-carboxylate: a key intermediate for potent endothelin receptor antagonists.

T. Hayama, T. Fukami, A. Naya, 2002, Bioorganic & Medicinal Chemistry.

Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist.

H. Iwaasa, M. Ando, M. Ishikawa, 2009, Bioorganic & medicinal chemistry.

Identification of positron emission tomography ligands for NPY Y5 receptors in the brain.

H. Iwaasa, T. Ohe, A. Kanatani, 2009, Bioorganic & medicinal chemistry letters.

Discovery of pyridone-containing imidazolines as potent and selective inhibitors of neuropeptide Y Y5 receptor.

H. Iwaasa, H. Matsushita, M. Ando, 2009, Bioorganic & medicinal chemistry.

Synthesis of 4-Cinnamylidene-2,5-cyclohexadien-1-ones

K. Kurosawa, Hirobumi Takahashi, A. Hashiba, 1978 .

Sequential radical cyclization, alkoxy-radical fragmentation, and recyclization processes: a novel method for the synthesis of fused cycloheptanones and cyclooctenones from cyclohexanones

A. Nishida, O. Yonemitsu, H. Takeda, 1990 .

Design, synthesis, and structure-activity relationship study of a novel class of ORL1 receptor antagonists based on N-biarylmethyl spiropiperidine.

S. Ozaki, H. Ohta, Masanori Asai, 2008, Bioorganic & medicinal chemistry letters.

Practical Syntheses of EnantiomericallyPure Key Intermediates of Opioid Receptor-like 1 (ORL1)Antagonists

H. Kigoshi, O. Okamoto, T. Yoshizumi, 2009 .

Sequential Radical Cyclization, Alkoxy Radical Fragmentation, and Recyclization Processes: A Novel Method for the Synthesis of Fused Cycloheptanones and Cyclooctenones from Cyclohexanones.

A. Nishida, O. Yonemitsu, H. Takeda, 1990 .

A novel class of cycloalkano[b]pyridines as potent and orally active opioid receptor-like 1 antagonists with minimal binding affinity to the hERG K+ channel.

Hisashi Ohta, Hiroshi Kawamoto, Satoshi Ozaki, 2008, Journal of medicinal chemistry.

Convenient synthesis of 2-alkylamino-6-carboxy-5,7-diarylcyclopenteno[1,2-b]pyridines via direct acylamination with imidoyl chlorides

T. Hayama, T. Fukami, T. Nishimura, 2005 .

Structure-activity relationships of a novel class of endothelin receptor selective antagonists; 6-carboxy-2-isopropylamino-5,7-diarylcyclopenteno[1,2-b]pyridines.

N. Kawanishi, T. Hayama, S. Ozaki, 2004, Bioorganic & medicinal chemistry letters.

Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists.

H. Iwaasa, T. Ohe, A. Kanatani, 2009, Bioorganic & medicinal chemistry letters.

Novel orally active NPY Y5 receptor antagonists: Synthesis and structure-activity relationship of spiroindoline class compounds.

H. Iwaasa, A. Kanatani, T. Fukami, 2009, Bioorganic & medicinal chemistry.

Potent and orally active ET(A) selective antagonists with 5,7-diarylcyclopenteno[1,2-b]pyridine-6-carboxylic acid structures.

T. Hayama, S. Ozaki, Y. Shibata, 2004, Bioorganic & medicinal chemistry.

6-Carboxy-5,7-diarylcyclopenteno[1,2-b]pyridine derivatives: a novel class of endothelin receptor antagonists.

T. Hayama, S. Ito, S. Ozaki, 2002, Bioorganic & medicinal chemistry.

2-Cyclohexylcarbonylbenzimidazoles as potent, orally available and brain-penetrable opioid receptor-like 1 (ORL1) antagonists.

Hisashi Ohta, Hiroshi Kawamoto, Satoshi Ozaki, 2009, Bioorganic & medicinal chemistry letters.

Discovery of tetrasubstituted imidazolines as potent and selective neuropeptide Y Y5 receptor antagonists: reduced human ether-a-go-go related gene potassium channel binding affinity and potent antiobesity effect.

H. Iwaasa, M. Ando, T. Ohe, 2009, Journal of medicinal chemistry.

2-Cyclohexylcarbonylbenzimidazoles as potent, orally available and brain-penetrable opioid receptor-like 1 (ORL1) antagonists.

S. Ozaki, Y. Ishii, S. Ito, 2009, Bioorganic & medicinal chemistry letters.

Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists.

H. Iwaasa, T. Ohe, A. Kanatani, 2009, Bioorganic & medicinal chemistry letters.