Ken-ichi Yoshida

发表

Identification of the 5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives as highly selective PDE4B inhibitors.

Mizuki Takahashi, S. Sasaki, T. Mikkaichi, 2014, Bioorganic & medicinal chemistry letters.

Inhibition of ergosterol synthesis by novel antifungal compounds targeting C-14 reductase.

K. Uoto, Y. Ishii, M. Hata, 2010, Medical mycology.

Irradiation by ultraviolet light-emitting diodes inactivates influenza a viruses by inhibiting replication and transcription of viral RNA in host cells.

K. Mawatari, A. Takahashi, Takaaki Shimohata, 2018, Journal of photochemistry and photobiology. B, Biology.

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: highly soluble and in vivo active quaternary ammonium analogue D13-9001, a potential preclinical candidate.

H. Nitanai, W. Watkins, K. Nakayama, 2007, Bioorganic & medicinal chemistry.

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model.

W. Watkins, K. Nakayama, K. Hoshino, 2004, Bioorganic & medicinal chemistry letters.

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 6: exploration of aromatic substituents.

H. Nitanai, W. Watkins, K. Nakayama, 2006, Bioorganic & medicinal chemistry.

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: Addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety.

W. Watkins, K. Nakayama, K. Hoshino, 2004, Bioorganic & medicinal chemistry letters.

MexAB-OprM-specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 1: discovery and early strategies for lead optimization.

T. Renau, W. Watkins, K. Nakayama, 2003, Bioorganic & medicinal chemistry letters.

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 2: achieving activity in vivo through the use of alternative scaffolds.

T. Renau, W. Watkins, K. Nakayama, 2003, Bioorganic & medicinal chemistry letters.

A Total Synthesis of Prunustatin A

Y. Usuki, H. Iio, Ken-ichi Yoshida, 2015 .

Evaluation of Inhibitory Activities of UK-2A, an Antimycin-Type Antibiotic, and Its Synthetic Analogues against the Production of Anti-inflammatory Cytokine IL-4.

T. Satoh, Ken-Ichi Fujita, Y. Usuki, 2018, Journal of natural products.

Total synthesis of splenocin B, a potent inhibitor of the pro-inflammatory cytokine from marine-derived Streptomyces sp.

Y. Usuki, H. Iio, Ken-ichi Yoshida, 2015 .

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 5: Carbon-substituted analogues at the C-2 position.

W. Watkins, K. Nakayama, K. Hoshino, 2006, Bioorganic & medicinal chemistry.

Differentiating analogous tRNA methyltransferases by fragments of the methyl donor.

S. Yokoyama, Takuhiro Ito, Ya-Ming Hou, 2011, RNA.

A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1.

Yutaka Ikeno, O. Ubukata, H. Hanzawa, 2018, Acta crystallographica. Section F, Structural biology communications.

Structural basis for methyl-donor–dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD

S. Yokoyama, S. Suh, Takuhiro Ito, 2015, Proceedings of the National Academy of Sciences.

Protein kinase C-epsilon protects PC12 cells against methamphetamine-induced death: possible involvement of suppression of glutamate receptor.

K. Uemura, T. Aki, K. Yamaguchi, 2003, Life sciences.

An Operon for a Putative ATP-Binding Cassette Transport System Involved in Acetoin Utilization ofBacillus subtilis

S. Ehrlich, Y. Fujita, Ken-ichi Yoshida, 2000, Journal of bacteriology.