H. Shirota

发表

ER-34122, a novel dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity in an arachidonic acid-induced ear inflammation model

M. Shinoda, N. Nagakura, S. Kobayashi, 1998, Inflammation Research.

E6201, a Novel Kinase Inhibitor of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase-1 and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase Kinase-1: In Vivo Effects on Cutaneous Inflammatory Responses by Topical Administration

F. Gusovsky, N. Ishii, T. Omae, 2010, Journal of Pharmacology and Experimental Therapeutics.

Atypical adenoma of the parathyroid gland

M. Shimomura, Toshitsugu Nakamura, H. Shirota, 1998 .

E6201 [(3S,4R,5Z,8S,9S,11E)-14-(Ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a Novel Kinase Inhibitor of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase (MEK)-1 and MEK Kinase-1: In Vitro Characterization o

F. Gusovsky, Jesse C. Chow, Y. Mizui, 2009, Journal of Pharmacology and Experimental Therapeutics.

A factor derived from polymorphonuclear leukocytes enhances interleukin-1-induced synovial cell collagenase and prostaglandin E2 production in rats.

R. Hashida, M. Kuwada, M. Kuwada, 1996, European journal of biochemistry.

Determination of inflamed paw surface temperature in rats.

H. Shiojiri, S. Kobayashi, T. Igarashi, 1984, Journal of pharmacological methods.

Stimulation of prostaglandin synthesis in cultured rat synovial cells by a factor derived from polymorphonuclear leukocytes.

S. Kobayashi, K. Yoshimatsu, R. Hashida, 1984, Prostaglandins.

Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2, III.

Y. Wang, F. Gusovsky, M. Ikemori-Kawada, 2010, Bioorganic & medicinal chemistry letters.

In vitro effect of N-methoxy-3-(3,5-ditert-butyl-4-hydroxybenzylidene)-2-pyrrolidone (E-5110), a novel nonsteroidal anti-inflammatory agent, on generation of some inflammatory mediators

K. Katayama, I. Yamatsu, H. Ikuta, 1987, Agents and Actions.

Synthesis and antiinflammatory activities of 3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-ones.

K. Katayama, I. Yamatsu, Y. Yamagishi, 1987, Journal of medicinal chemistry.

A novel inhibitor of IL-1 generation, E5090: in vivo inhibitory effect on the generation of IL-1-like factor and on granuloma formation in an air-pouch model.

K. Chiba, M. Goto, H. Shirota, 1991, Agents and actions. Supplements.

[Clear cell carcinoma of the gallbladder].

S. Nomura, H. Shirota, T. Nakamura, 1996, Ryoikibetsu shokogun shirizu.

Discovery of a potent, metabolically stabilized resorcylic lactone as an anti-inflammatory lead.

F. Gusovsky, Y. Wang, J. Harmange, 2009, Bioorganic & medicinal chemistry letters.

Discovery of an in vitro and in vivo potent resorcylic lactone analog of LL-Z1640-2 as anti-inflammatory lead, II.

Y. Wang, F. Gusovsky, M. Ikemori-Kawada, 2010, Bioorganic & medicinal chemistry letters.

3-(5-Alkyl-4-hydroxy-3-methoxy-1-naphthalenyl)-2-methyl-2-propenoic acids as orally active inhibitors of IL-1 generation.

H. Sakurai, S. Hibi, M. Tanaka, 1991, Journal of medicinal chemistry.

[A case of primary malignant fibrous histiocytoma of the gallbladder and a review of the cases in Japan].

N. Yamamura, M. Matsuzawa, A. Nagata, 1998, Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology.

Antitumor effects of eribulin depend on modulation of the tumor microenvironment by vascular remodeling in mouse models

T. Akagi, S. Hamamichi, J. Matsui, 2017, Cancer science.

Acute suppurative thyroiditis resulting from infection through the piriform sinus fistula

T. Yokozawa, A. Sugenoya, F. Iida, 1984 .

A Case of Giant Brunner's Gland Hyperplasia in the Duodenum resected by Incising the Gastric Wall

K. Nishiyama, S. Kajikawa, Kou Shimada, 2009 .

A CASE OF BREAST METASTASIS MIMICKING INFLAMMATORY BREAST CANCER FROM COLON CANCER

Kou Shimada, Kuniyuki Gomi, K. Yazawa, 2010 .

Comparison of Tl-201 chloride and Ga-67 citrate scintigraphy in the diagnosis of thyroid tumor: concise communication.

O. Senga, M. Miyakawa, K. Yano, 1982, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Macrofollicular variant of papillary thyroid carcinoma

K. Sano, S. Nariya, Toshitsugu Nakamura, 1998, Pathology international.

Effects of ER-34122, a novel dual 5-lipoxygenase/cyclooxygenase inhibitor, on indices of early articular lesion in MRL/MpJ-lpr/lpr mice

M. Shinoda, N. Nagakura, S. Kobayashi, 1999, Inflammation Research.

sonography for trauma, DIC-CT: drip infusion cholan-giography-CT

S. Kajikawa, M. Kono, K. Yazawa, 2009 .

Diagnostic usefulness of201T1-chloride scintigraphy for preoperative localization of parathyroid tumors

T. Kasuga, A. Sugenoya, Shinya Kobayashi, 1981, The Japanese journal of surgery.

Plasma and bone osteocalcin levels in rats with type II collagen-induced arthritis.

K. Katayama, M. Kuwada, K. Terato, 1988, Arthritis and rheumatism.

[A case of rectal gastrointestinal stromal tumor in an elderly patient who was successfully treated with imatinib mesylate with no significant adverse events].

M. Mihara, S. Kajikawa, K. Maruyama, 2014, Gan to kagaku ryoho. Cancer & chemotherapy.

A novel antagonist of the prostaglandin E2 EP4 receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models

F. Gusovsky, I. Matsumoto, T. Sumida, 2010, British journal of pharmacology.

A CASE OF PEDUNCULATED GASTROINTESTINAL STROMAL TUMOR OF THE LESSER OMENTUM PRESENTING PREOPERATIVELY AS A HEMOPERITONEUM

S. Kajikawa, Kou Shimada, Kuniyuki Gomi, 2010 .

Inhibitory effect of indomethacin farnesil, a novel antiinflammatory prodrug, on carrgeenin-induced inflammation in rats

S. Kobayashi, S. Kumakura, S. Abe, 1990, Agents and Actions.

Interleukin-1-like activity in the exudate of air-pouch inflammation in rats, and its participation in granuloma formation

K. Katayama, I. Yamatsu, K. Chiba, 1989, Agents and Actions.