B. Hollingshead

发表

Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases.

S. Wright, J. D. Clark, M. Hegen, 2020, Journal of medicinal chemistry.

Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.

K. Fennell, O. Fedorov, P. Loria, 2022, Journal of medicinal chemistry.

The hsp90 Co-chaperone XAP2 Alters Importin β Recognition of the Bipartite Nuclear Localization Signal of the Ah Receptor and Represses Transcriptional Activity*

G. Perdew, J. Petrulis, P. Ramadoss, 2003, The Journal of Biological Chemistry.

The aryl hydrocarbon receptor complex and the control of gene expression.

G. Perdew, T. V. Beischlag, B. Hollingshead, 2008, Critical reviews in eukaryotic gene expression.

Distinct Roles for Aryl Hydrocarbon Receptor Nuclear Translocator and Ah Receptor in Estrogen-Mediated Signaling in Human Cancer Cell Lines

Gratien G. Prefontaine, G. Perdew, G. Prefontaine, 2012, PloS one.

Comparison of hepatic transcription profiles of locked ribonucleic acid antisense oligonucleotides: evidence of distinct pathways contributing to non-target mediated toxicity in mice.

A. Burdick, Ahmed Enayetallah, A. Ryan, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Sequence motifs associated with hepatotoxicity of locked nucleic acid—modified antisense oligonucleotides

A. Burdick, J. W. Davis, S. Makarov, 2014, Nucleic acids research.

Inflammatory signaling and aryl hydrocarbon receptor mediate synergistic induction of interleukin 6 in MCF-7 cells.

G. Perdew, T. V. Beischlag, P. Ramadoss, 2008, Cancer research.

Inflammatory signaling and aryl hydrocarbon receptor mediate synergistic induction of interleukin 6 in MCF-7 cells.

G. Perdew, T. V. Beischlag, P. Ramadoss, 2008, Cancer research.

Combination of Inflammatory Si gnaling and an AhR Ligand Leads to Synergistic Induction of IL-6

G. Perdew, Brett C Dinatale, B. Hollingshead, 2007 .

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).

Li Xing, Eddine Saiah, David Lin, 2018, Journal of medicinal chemistry.

The Aryl Hydrocarbon (Ah) Receptor Transcriptional Regulator Hepatitis B Virus X-associated Protein 2 Antagonizes p23 Binding to Ah Receptor-Hsp90 Complexes and Is Dispensable for Receptor Function*

G. Perdew, J. Petrulis, Brett D. Hollingshead, 2004, Journal of Biological Chemistry.

Experiments in the EpiDerm™ 3D Skin in Vitro Model and Minipigs in Vivo Indicate Comparatively Lower in Vivo Skin Sensitivity of Topically Applied Aneugenic Compounds.

J. Cook, Z. Radi, M. Schuler, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Demonstration of In Vitro to In Vivo Translation of a TYK2 Inhibitor That Shows Cross Species Potency Differences

J. D. Clark, M. Hegen, M. Dowty, 2020, Scientific Reports.

Zucker Lean Rats With Hepatic Steatosis Recapitulate Asymptomatic Metabolic Syndrome and Exhibit Greater Sensitivity to Drug-Induced Liver Injury Compared With Standard Nonclinical Sprague-Dawley Rat Model

A. Burdick, J. W. Davis, A. Kopec, 2020, Toxicologic pathology.

An Orthogonal Methods Assessment of Topical Drug Concentrations in Skin and the Impact for Risk Assessment in the Viable Epidermis.

R. Caprioli, K. Beaumont, J. Cook, 2021, Regulatory toxicology and pharmacology : RTP.

Lack of direct bone effect of tofacitinib, a JAK inhibitor, in juvenile rats and evaluation of the association between offspring growth and femur length.

C. Bowman, G. Cappon, Z. Radi, 2022, Reproductive toxicology.

Divergent roles of hepatitis B virus X-associated protein 2 (XAP2) in human versus mouse Ah receptor complexes.

G. Perdew, J. Petrulis, P. Ramadoss, 2004, Biochemistry.

Endogenous Hepatic Expression of the Hepatitis B Virus X-Associated Protein 2 Is Adequate for Maximal Association with Aryl Hydrocarbon Receptor-90-kDa Heat Shock Protein Complexes

G. Perdew, Rushang D. Patel, B. Hollingshead, 2006, Molecular Pharmacology.

Estrogen Receptor Expression Is Required for Low-Dose Resveratrol-Mediated Repression of Aryl Hydrocarbon Receptor Activity

G. Perdew, Mark P. Labrecque, Kevin J. Tam, 2010, Journal of Pharmacology and Experimental Therapeutics.

Microsoft Word-21746471-file00

G. Perdew, Kevin J. Tam, T. V. Beischlag, 2010 .

Aryl‐hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver

G. Perdew, Rushang D. Patel, Brett D. Hollingshead, 2007, Hepatology.