R. Beckett

发表

The synthesis of novel matrix metalloproteinase inhibitors employing the Ireland-Claisen rearrangement.

A. H. Drummond, J. Cossins, M. Whittaker, 1998, Bioorganic & medicinal chemistry letters.

The synthesis and biological evaluation of non-peptidic matrix metalloproteinase inhibitors.

J. W. Ward, A. H. Drummond, M. Whittaker, 1999, Bioorganic & medicinal chemistry letters.

Inhibition of metalloproteinases enhances the internalization of anti‐CD30 antibody Ki‐3 and the cytotoxic activity of Ki‐3 immunotoxin

S. Barth, H. Lemke, A. Engert, 2002, International journal of cancer.

Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury.

E. Howard, A. Mitschler, M. V. Van Zandt, 2013, Journal of medicinal chemistry.

Structure–reactivity relationships in the inactivation of elastase by β-sultams

R. Austin, A. Davis, J. Wood, 2003 .

Asymmetric synthesis of BB-3497--a potent peptide deformylase inhibitor.

M. Whittaker, L. Pratt, A. Miller, 2001, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the methylene spacer and the P1' side chain.

A. Ayscough, J. Clements, M. Whittaker, 2003, Bioorganic & medicinal chemistry letters.

Stereoselective formation of 4-substituted-1,4-dihydronicotinoyl complexes utilizing the chiral auxiliary [(η5-C5H5)Fe(CO)(PPh3)]

M. Whittaker, S. Davies, R. Beckett, 1993 .

α‐Aminophosphonate Derivatives as Nucleophiles in Diastereoselective and Enantioselective Palladium Catalyzed Allylic Substitution Reactions.

Jonathan M. J. Williams, R. Beckett, I. Baldwin, 1995 .

Asymmetric synthesis of (1R,8S)- and (1S,8S)-1-hydroxypyrrolizidin-3-ones via the aldol reaction between N-boc-(S)-prolinal and chiral acetate enolate equivalents derived from (S)- and (R)-[(η5-C5H5)Fe(CO)(PPh3)COCH3]

A. Mortlock, S. Davies, R. Beckett, 1992 .

Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the metal binding group.

J. Clements, M. Whittaker, S. Doel, 2002, Bioorganic & medicinal chemistry letters.

Antibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase Inhibitor

D. Rice, P. Baker, Anthony E. Brown, 2001, Antimicrobial Agents and Chemotherapy.

Synthesis of quaternary α-amino acid-based arginase inhibitors via the Ugi reaction.

A. Mitschler, M. V. Van Zandt, A. Podjarny, 2013, Bioorganic & medicinal chemistry letters.

Inhibition of Matrix Metalloproteinases: An examination of the S1′ pocket

A. H. Drummond, E. Bone, M. Whittaker, 1997 .

Patent Update Oncologic, Endocrine & Metabolic: Oncologic, Endocrine & Metabolic: Recent advances in the field of matrix metalloproteinase inhibitors

R. Beckett, 1996 .

A Short Diastereoselective Synthesis of 2,3‐Disubstituted Succinates.

Z. Spavold, R. Beckett, M. Crimmin, 1994 .

Peptide deformylase inhibitors with activity against respiratory tract pathogens.

J. Clements, M. Whittaker, G. Pain, 2004, Bioorganic & medicinal chemistry letters.

Matrix metalloproteinase inhibitors 1998

Mark Whittaker, M. Whittaker, R.Paul Beckett, 1998 .

Oral anti-pneumococcal activity and pharmacokinetic profiling of a novel peptide deformylase inhibitor.

J. Clements, K. Johnson, U. Hoch, 2004, The Journal of antimicrobial chemotherapy.

Structure--activity relationships of the peptide deformylase inhibitor BB-3497: modification of the P2' and P3' side chains.

A. Ayscough, J. Clements, M. Whittaker, 2003, Bioorganic & medicinal chemistry letters.