T. Malone

发表

(S)-4-Methyl-2-(methylamino)pentanoic acid [4, 4-bis(4-fluorophenyl)butyl]amide hydrochloride, a novel calcium channel antagonist, is efficacious in several animal models of pain.

D. T. Connor, B. Roth, J. Schmidt, 2000, Journal of medicinal chemistry.

Neuronal N-type calcium channel blockers: a series of 4-piperidinylaniline analogs with analgesic activity.

M. R. Feng, B. Szoke, S. Lotarski, 2000, Drug design and discovery.

Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers.

K. Tarczy-Hornoch, P. Yuen, B. Szoke, 1999, Bioorganic & medicinal chemistry letters.

Synthesis of cis-4-(phosphonooxy)-2-piperidinecarboxylic acid, an N-methyl-D-aspartate antagonist

S. Hays, G. Johnson, T. Malone, 1991 .

Synthesis and anticonvulsant activity of the (+)- and (−)-enantiomers of 1,2,3,4-tetrahydro-5-(2-phosphonoethyl)-3-isoquinolinecarboxylic acid, a competitive NMDA antagonist

Jiang-Ping Wu, C. Bigge, C. Taylor, 1993 .

Iminium ion and acyliminium ion initiated cyclization reactions of vinylsilanes. Regiocontrolled synthesis of tetrahydropyridines and related heterocycles

L. Overman, T. Malone, C. J. Flann, 1987 .

Iminium ion and acyl iminium ion initiated cyclizations of vinylsilanes. Regiocontrolled construction of unsaturated azacyclics

L. Overman, G. P. Meier, T. Malone, 1983 .

Regioselective Synthesis of Tetrahydropyridines: 1-(4-Methoxyphenyl)-1,2,5,6-tetrahydropyridine

L. Overman, T. Malone, C. J. Flann, 2003 .

Generation of N-methyl-D-aspartate agonist and competitive antagonist pharmacophore models. Design and synthesis of phosphonoalkyl-substituted tetrahydroisoquinolines as novel antagonists.

C. Humblet, D. Ortwine, C. Bigge, 1992, Journal of medicinal chemistry.

NS 257 (1,2,3,6,7,8-hexahydro-3(hydroxyimino)-N,N,7-trimethyl-2-oxobenzo[2,1-b:3,4-c']dipyrrole-5-sulfonamide) is a potent, systemically active ampa receptor antagonist

E. Nielsen, F. Marcoux, J. Drejer, 1994 .

Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists.

F. Marcoux, C. Bigge, J. Drummond, 1989, Journal of medicinal chemistry.

Overview: Agonists, Antagonists and Modulators of the N-methyl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) Subtypes of Glutamate Receptors

C. Bigge, T. Malone, 1993 .

Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity.

D. Ortwine, C. Bigge, P. Boxer, 1995, Journal of medicinal chemistry.

Synthesis and pharmacological evaluation of 4a-phenanthrenamine derivatives acting at the phencyclidine binding site of the N-methyl-D-aspartate receptor complex.

D. Ortwine, C. Bigge, S. Hays, 1993, Journal of medicinal chemistry.

Synthesis and biological activity of conformationally constrained 4a-phenanthreneamine derivatives as noncompetitive NMDA antagonists

D. Ortwine, A. Probert, G. Johnson, 1993 .