Leah E. Mechanic

发表

Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions

Stephen J. Chanock, Leah E. Mechanic, Brian T. Luke, 2008, BMC Bioinformatics.

The National Cancer Institute (NCI) Informatics Technology for Cancer Research Program (ITCR)

Juli D. Klemm, David Miller, Warren A. Kibbe, 2017, CRI.

Genetic Simulation Resources and the GSR Certification Program

Bo Peng, John Clarke, Huann-Sheng Chen, 2018, Bioinform..

Genetic Simulation Resources: a website for the registration and discovery of genetic data simulators

Bo Peng, John Clarke, Huann-Sheng Chen, 2013, Bioinform..

Pharmacogenomics in oncology care

Leah E. Mechanic, Kelly K. Filipski, A. Freedman, 2014, Front. Genet..

Robustness of Next Generation Sequencing on Older Formalin-Fixed Paraffin-Embedded Tissue

Brenda Y. Hernandez, Charles F. Lynch, Leah E. Mechanic, 2015, PloS one.

Lessons Learned From Past Gene-Environment Interaction Successes

Peter Kraft, Kimberly McAllister, Nilanjan Chatterjee, 2017, American journal of epidemiology.

A Review of NCI's Extramural Grant Portfolio: Identifying Opportunities for Future Research in Genes and Environment in Cancer

Leah E. Mechanic, E. Gillanders, S. Schully, 2013, Cancer Epidemiology, Biomarkers & Prevention.

Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer

Leah E. Mechanic, E. Bowman, C. Harris, 2011, Oncogene.

Childhood Exposure to Secondhand Smoke and Functional Mannose Binding Lectin Polymorphisms Are Associated with Increased Lung Cancer Risk

Leah E. Mechanic, S. Chanock, E. Bowman, 2009, Cancer Epidemiology, Biomarkers & Prevention.

Planned variation in preanalytical conditions to evaluate biospecimen stability in the National Children’s Study (NCS)

Leah E. Mechanic, L. Mechanic, A. Mendez, 2013, Clinical chemistry and laboratory medicine.

Next generation analytic tools for large scale genetic epidemiology studies of complex diseases

Kathryn Roeder, Peter Kraft, Matthew Stephens, 2012, Genetic epidemiology.

Mutations in the Tyrosine Kinase Domain of the Epidermal Growth Factor Receptor in Non–Small Cell Lung Cancer

Leah E. Mechanic, E. Bowman, C. Harris, 2005, Clinical Cancer Research.

Gene-Environment Interactions in Human Health

Leah E. Mechanic, C. Hutter, L. Mechanic, 2015 .

SEER Cancer Registry Biospecimen Research: Yesterday and Tomorrow

Muin J Khoury, Sheri D Schully, Leah E Mechanic, 2014, Cancer Epidemiology, Biomarkers & Prevention.

Gene‐Environment Interactions in Cancer Epidemiology: A National Cancer Institute Think Tank Report

Peter Kraft, Nilanjan Chatterjee, Leah E. Mechanic, 2013, Genetic epidemiology.

Current Challenges and New Opportunities for Gene-Environment Interaction Studies of Complex Diseases.

Bhramar Mukherjee, Peng Wei, Kimberly McAllister, 2017, American journal of epidemiology.

Exploring SNP‐SNP interactions and colon cancer risk using polymorphism interaction analysis

Leah E. Mechanic, C. Harris, S. Ambs, 2006, International journal of cancer.

Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier.

Leah E. Mechanic, Krista A. Zanetti, X. Wang, 2007, Journal of the National Cancer Institute.

Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies

Beate Ritz, Jacqueline Kerr, Bhramar Mukherjee, 2017, Cancer Epidemiology, Biomarkers & Prevention.

International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.

Paolo Vineis, Giuseppe Matullo, Yun-Chul Hong, 2008, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation.

Leah E. Mechanic, V. Rotter, C. Harris, 2003, The Journal of clinical investigation.

Nitric Oxide, a Mediator of Inflammation, Suppresses Tumorigenesis

Leah E. Mechanic, C. Harris, S. Hussain, 2004, Cancer Research.

Review of the Gene‐Environment Interaction Literature in Cancer: What Do We Know?

Naoko I Simonds, Sheri D Schully, Leah E Mechanic, 2016, Genetic epidemiology.

The mannose-binding lectin (MBL2) haplotype and breast cancer: an association study in African-American and Caucasian women.

Brian Staats, Robert Welch, Leah E Mechanic, 2006, Carcinogenesis.

EGFR Somatic Mutations in Lung Tumors: Radon Exposure and Passive Smoking in Former- and Never-Smoking U.S. Women

Leah E. Mechanic, C. Harris, Mohammed A. Khan, 2012, Cancer Epidemiology, Biomarkers & Prevention.

p53-Induced Up-Regulation of MnSOD and GPx but not Catalase Increases Oxidative Stress and Apoptosis

Leah E. Mechanic, C. Harris, A. Robles, 2004, Cancer Research.

Opportunities for Gene and Environment Research in Cancer: An Updated Review of NCI's Extramural Grant Portfolio

Leah E. Mechanic, L. Mechanic, G. Lai, 2020, Cancer Epidemiology, Biomarkers & Prevention.

Nitric oxide is a key component in inflammation-accelerated tumorigenesis.

Leah E. Mechanic, J. Weiss, C. Harris, 2008, Cancer research.

Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer.

Leah E. Mechanic, E. Bowman, C. Harris, 2011, Journal of the National Cancer Institute.

Serum Concentrations of Cytokines and Lung Cancer Survival in African Americans and Caucasians

Leah E. Mechanic, E. Bowman, C. Harris, 2009, Cancer Epidemiology Biomarkers & Prevention.

Traceback: A Proposed Framework to Increase Identification and Genetic Counseling of BRCA1 and BRCA2 Mutation Carriers Through Family-Based Outreach.

Leah E. Mechanic, F. Couch, D. Bowtell, 2017, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Lung cancer survival and functional polymorphisms in MBL2, an innate-immunity gene.

Leah E. Mechanic, S. Chanock, E. Bowman, 2007, Journal of the National Cancer Institute.

Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case-control study.

Leah E. Mechanic, R. Millikan, L. Mechanic, 2006, Carcinogenesis.

Facilitating cancer systems epidemiology research

Leah E. Mechanic, E. Gillanders, L. Mechanic, 2021, PloS one.

Serum estrogen and tumor-positive estrogen receptor-alpha are strong prognostic classifiers of non-small-cell lung cancer survival in both men and women.

Leah E Mechanic, Michele R Forman, Leah E. Mechanic, 2010, Carcinogenesis.

Approaches to integrating germline and tumor genomic data in cancer research.

Leah E. Mechanic, E. Gillanders, K. Goddard, 2014, Carcinogenesis.

A Region Near the C-Terminal End ofEscherichia coli DNA Helicase II Is Required for Single-Stranded DNA Binding

Leah E. Mechanic, L. Mechanic, S. W. Matson, 1999, Journal of bacteriology.

Escherichia coli MutL Loads DNA Helicase II onto DNA*

Leah E. Mechanic, L. Mechanic, S. W. Matson, 2000, The Journal of Biological Chemistry.

Escherichia coli DNA Helicase II Is Active as a Monomer*

Leah E. Mechanic, L. Mechanic, M. Hall, 1999, The Journal of Biological Chemistry.

Association of MTHFR gene polymorphisms with breast cancer survival

Leah E. Mechanic, S. Chanock, S. Ambs, 2006, BMC Cancer.

A Systematic Literature Review of Whole Exome and Genome Sequencing Population Studies of Genetic Susceptibility to Cancer

Leah E. Mechanic, E. Gillanders, T. Lam, 2020, Cancer Epidemiology, Biomarkers & Prevention.

Polymorphisms in XPD and TP53 and mutation in human lung cancer.

Leah E Mechanic, Leah E. Mechanic, E. Bowman, 2004, Carcinogenesis.

Awareness and use of genetic testing: An analysis of the Health Information National Trends Survey 2020

Leah E. Mechanic, E. Gillanders, K. Helzlsouer, 2022, Genetics in medicine : official journal of the American College of Medical Genetics.

On the application, reporting, and sharing of in silico simulations for genetic studies

Bo Peng, Naoko I Simonds, Huann-Sheng Chen, 2020, Genetic epidemiology.

Elevated lung cancer risk is associated with deficiencies in cell cycle checkpoints: genotype and phenotype analyses from a case‐control study

Leah E. Mechanic, Ourania Kosti, E. Bowman, 2010, International journal of cancer.

Quantitative detection of p53 mutations in plasma DNA from tobacco smokers.

Leah E. Mechanic, E. Bowman, K. Kumamoto, 2006, Cancer research.

Differential Serum Cytokine Levels and Risk of Lung Cancer Between African and European Americans

Leah E. Mechanic, E. Bowman, C. Harris, 2015, Cancer Epidemiology, Biomarkers & Prevention.

Associations between anthropometry, cigarette smoking, alcohol consumption, and non-Hodgkin lymphoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

Leah E. Mechanic, G. Colditz, P. Hartge, 2010, American journal of epidemiology.