K. van Huynegem

Intestinal Delivery of Proinsulin and IL-10 via Lactococcus lactis Combined With Low-Dose Anti-CD3 Restores Tolerance Outside the Window of Acute Type 1 Diabetes Diagnosis

C. Mathieu, M. Atkinson, C. Gysemans, 2020, Frontiers in Immunology.

Immunomodulation by genetically engineered lactic acid bacteria.

L. Steidler, M. Loos, K. van Huynegem, 2009, Frontiers in bioscience.

Oral Delivery of Glutamic Acid Decarboxylase (GAD)-65 and IL10 by Lactococcus lactis Reverses Diabetes in Recent-Onset NOD Mice

C. Mathieu, M. Atkinson, C. Gysemans, 2014, Diabetes.

Lactocepin secreted by Lactobacillus exerts anti-inflammatory effects by selectively degrading proinflammatory chemokines.

B. Kuster, Hannes Hahne, G. Pérez-Martínez, 2012, Cell host & microbe.

Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in mice.

C. Mathieu, M. Atkinson, C. Gysemans, 2012, The Journal of clinical investigation.

Clinical development of lactocepin: a novel bacterial biologic?

L. Steidler, K. van Huynegem, 2012, Expert review of clinical immunology.

Trimming of two major type 1 diabetes driving antigens, GAD65 and IA-2, allows for successful expression in Lactococcus lactis.

C. Mathieu, C. Gysemans, L. Steidler, 2015, Beneficial microbes.