I. Gunawardana

发表

Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides.

L. Kifle, K. Marsh, G. Zhu, 2001, Journal of medicinal chemistry.

Single-agent inhibition of Chk1 is antiproliferative in human cancer cell lines in vitro and inhibits tumor xenograft growth in vivo.

S. Gross, J. Blake, K. Davies, 2011, Oncology research.

Discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. Selective inhibition of ICAM-1 and E-selectin expression.

L. Kifle, C. McCarty, K. Marsh, 2001, Journal of medicinal chemistry.

New antimitotic agents with activity in multi-drug-resistant cell lines and in vivo efficacy in murine tumor models.

S. Rosenberg, S. L. Gwaltney, R. B. Credo, 2001, Journal of medicinal chemistry.

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.

S. Weiler, B. Brandhuber, G. Vigers, 2008, Bioorganic & medicinal chemistry letters.

Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases.

P. Wiedeman, J. Trevillyan, K. Marsh, 1998, Current pharmaceutical design.

Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system.

K. Scearce-Levie, M. Volgraf, G. Vigers, 2014, Journal of medicinal chemistry.

Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species.

G. Vigers, Xingrong Liu, Darin J. Smith, 2013, Journal of medicinal chemistry.

Prodrug thiamine analogs as inhibitors of the enzyme transketolase.

S. Weiler, C. Lemieux, Stephen S. Gonzales, 2008, Bioorganic & medicinal chemistry letters.

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.

S. Weiler, B. Brandhuber, G. Vigers, 2008, Bioorganic & medicinal chemistry letters.

Studies on an immunosuppressive macrolactam, ascomycin: synthesis of a C-33 hydroxyl derivative.

G. Hsieh, K. Mollison, J. Luly, 1998, Bioorganic & medicinal chemistry letters.