Ge-Fei Hao

发表

Computational Discovery of Potent and Bioselective Protoporphyrinogen IX Oxidase Inhibitor via Fragment Deconstruction Analysis.

Yue Zhang, Guangfu Yang, Z. Xi, 2017, Journal of agricultural and food chemistry.

Conformational adjustment overcomes multiple drug-resistance mutants of tropomyosin receptor kinase.

Wei Huang, Guang-Fu Yang, Long-Can Mei, 2022, European journal of medicinal chemistry.

A Comprehensive Analysis of Protein Data Bank reveals Low Desolvation Penalty in π-Cation System

Guangfu Yang, Jing-Fang Yang, Qing X. Li, 2020 .

Structure-activity relationship study of novel quinazoline-based 1,6-naphthyridinones as MET inhibitors with potent antitumor efficacy.

Wei Huang, Xiao-Lei Zhu, Ming-Shu Wang, 2020, European journal of medicinal chemistry.

Design, synthesis and herbicidal activity of novel quinazoline-2,4-diones as 4-hydroxyphenylpyruvate dioxygenase inhibitors.

Wenchao Yang, Guangfu Yang, Tao Chen, 2015, Pest management science.

Real-Time Fluorescence Imaging of the Abscisic Acid Receptor Allows Nondestructive Visualization of Plant Stress.

Moxian Chen, Jian-Hua Zhang, Jun Yin, 2022, ACS applied materials & interfaces.

Genetic Engineering and Chemical Control Related to Abscisic Acid for Improving Plant Drought Tolerance.

Guangfu Yang, Jing-Fang Yang, Ge-Fei Hao, 2021, Journal of agricultural and food chemistry.

An efficient one-pot access to N-(pyridin-2-ylmethyl) substituent biphenyl-4-sulfonamides through water-promoted, palladium-catalyzed, microwave-assisted reactions

Wei Huang, Guangfu Yang, Jing-Fang Yang, 2015 .

Genome-wide identification and functional analysis of the splicing component SYF2/NTC31/p29 across different plant species

Bei Gao, Moxian Chen, Jianhua Zhang, 2018, Planta.

Thermodynamic database supports deciphering protein-nucleic acid interactions.

Guangfu Yang, Long-Can Mei, Ge-Fei Hao, 2022, Trends in biotechnology.

A drug-likeness toolbox facilitates ADMET study in drug discovery.

Chen-Yang Jia, Guang-Fu Yang, Ge-Fei Hao, 2019, Drug discovery today.

Design and synthesis of 1-(benzothiazol-5-yl)-1H-1,2,4-triazol-5-ones as protoporphyrinogen oxidase inhibitors.

Yin Tan, Guangfu Yang, Z. Xi, 2013, Bioorganic & medicinal chemistry.

Understanding resistance mechanism of protoporphyrinogen oxidase-inhibiting herbicides: insights from computational mutation scanning and site-directed mutagenesis.

Yin Tan, Guangfu Yang, Z. Xi, 2014, Journal of agricultural and food chemistry.

Synthesis and herbicidal evaluation of triketone-containing quinazoline-2,4-diones.

Qiong Chen, Wenchao Yang, Guangfu Yang, 2014, Journal of agricultural and food chemistry.

Quantitative structure-activity relationships of 1,3,4-thiadiazol-2(3H)-ones and 1,3,4-oxadiazol-2(3H)-ones as human protoporphyrinogen oxidase inhibitors.

Guangfu Yang, Z. Xi, Qiongyou Wu, 2012, Bioorganic & medicinal chemistry.

Pyrazole-Isoindoline-1,3-dione Hybrid: A Promising Scaffold for 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors.

Qiong Chen, Wenchao Yang, Guangfu Yang, 2019, Journal of agricultural and food chemistry.

Bioactive conformation analysis of cyclic imides as protoporphyrinogen oxidase inhibitor by combining DFT calculations, QSAR and molecular dynamic simulations.

Yin Tan, Guangfu Yang, Z. Xi, 2009, Bioorganic & medicinal chemistry.

Structure–activity relationships of diphenyl-ether as protoporphyrinogen oxidase inhibitors: insights from computational simulations

Ying Tan, Ge-Fei Hao, Guangfu Yang, 2011, J. Comput. Aided Mol. Des..

Protoporphyrinogen oxidase inhibitor: an ideal target for herbicide discovery.

Guangfu Yang, Sheng-Gang Yang, Y. Zuo, 2011, Chimia.

Synthesis and Herbicidal Activity of Triketone-Quinoline Hybrids as Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors.

Qiong Chen, Wenchao Yang, Guangfu Yang, 2015, Journal of agricultural and food chemistry.

Computational discovery of picomolar Q(o) site inhibitors of cytochrome bc1 complex.

Ge-Fei Hao, Guang-Fu Yang, Xiao-Lei Zhu, 2012, Journal of the American Chemical Society.

A simple quinoline-derived fluorescent sensor for the selective and sequential detection of copper(II) and sulfide ions and its application in living-cell imaging

Yuyang Jiang, Ying Tan, Chunyan Tan, 2016 .

Coumarin-based novel fluorescent zinc ion probe in aqueous solution

Wenchao Yang, Guangfu Yang, Ge‐Fei Hao, 2013 .

A dual-response quinoline-based fluorescent sensor for the detection of Copper (II) and Iron(III) ions in aqueous medium

Yuyang Jiang, Ying Tan, Chunyan Tan, 2017 .

Unveiling toxicity profile for food risk components: A manually curated toxicological databank of food-relevant chemicals.

J. Simal-Gándara, Fan Wang, Zhi-Zheng Wang, 2022, Critical reviews in food science and nutrition.

Chemical Manipulation of Abscisic Acid Signaling: A New Approach to Abiotic and Biotic Stress Management in Agriculture

Jian‐Kang Zhu, Guangfu Yang, Jing-Fang Yang, 2020, Advanced science.

Phylogenetic comparison of plant U1-70K gene family, central spliceosomal proteins on 5' splice site determination, in response to developmental cues and stress conditions.

Bei Gao, Moxian Chen, Jianhua Zhang, 2020, The Plant journal : for cell and molecular biology.

Mechanistic insights into the substrate recognition of PPO: toward the rational design of effective inhibitors.

C. Zhan, Guangfu Yang, Ge-Fei Hao, 2014, Future medicinal chemistry.

Computational and Experimental Insights into the Mechanism of Substrate Recognition and Feedback Inhibition of Protoporphyrinogen Oxidase

C. Zhan, Yin Tan, Guangfu Yang, 2013, PloS one.

Computational design of novel inhibitors to overcome weed resistance associated with acetohydroxyacid synthase (AHAS) P197L mutant.

Qiong Chen, Guangfu Yang, Z. Xi, 2017, Pest management science.

Proteogenomic analysis reveals alternative splicing and translation as part of the abscisic acid response in Arabidopsis seedlings

Ge-Fei Hao, Ruo Zhou, Alisdair R Fernie, 2017, The Plant journal : for cell and molecular biology.

Genome-wide Phylogenetic and Structural Analysis reveals the Molecular Evolutionary Mechanisms of ABA Receptor Gene Family.

Moxian Chen, Jian-Hua Zhang, Guangfu Yang, 2019, Journal of experimental botany.

PTMdyna: exploring the influence of post-translation modifications on protein conformational dynamics

Guangfu Yang, Jing-Fang Yang, Fan Wang, 2021, Briefings Bioinform..

Systematic characterization of the branch point binding protein, splicing factor 1, gene family in plant development and stress responses

Moxian Chen, Jianhua Zhang, Caie Wu, 2019, BMC Plant Biology.

PADFrag: A Database Built for the Exploration of Bioactive Fragment Space for Drug Discovery

Jing-Fang Yang, Wen Jiang, Ge-Fei Hao, 2018, J. Chem. Inf. Model..

AIMMS suite: a web server dedicated for prediction of drug resistance on protein mutation

Feng-Xu Wu, Fan Wang, Jing-Fang Yang, 2018, Briefings Bioinform..

HISNAPI: a bioinformatic tool for dynamic hot spot analysis in nucleic acid-protein interface with a case study

Guangfu Yang, Long-Can Mei, Fan Wang, 2021, Briefings Bioinform..

Protein Kinases as Potential Targets Contribute to the Development of Agrochemicals.

Zhi-Zheng Wang, Ge-Fei Hao, Guang-Fu Yang, 2023, Journal of agricultural and food chemistry.

Catalase Inhibitors with Dual Pro‐Oxidant Effect as New Therapeutic Agents in Castration‐Resistant Prostate Cancer

Pengfei Yi, Guangfu Yang, Wei Huang, 2020, Advanced Therapeutics.

Fragment-based drug design facilitates selective kinase inhibitor discovery.

Guangfu Yang, Zhi-Zheng Wang, Ge-Fei Hao, 2021, Trends in pharmacological sciences.

Web resources facilitate drug discovery in treatment of COVID-19

Guangfu Yang, Long-Can Mei, Ge-Fei Hao, 2021, Drug Discovery Today.

Bioinformatics toolbox for exploring protein phosphorylation network

Guang-Fu Yang, Ge-Fei Hao, Xing-Xing Shi, 2020, Briefings Bioinform..

Computational methods for predicting hotspots at protein–RNA interfaces

Guangfu Yang, Long-Can Mei, Ge-Fei Hao, 2021, Wiley interdisciplinary reviews. RNA.

Anti-CRISPRdb: a comprehensive online resource for anti-CRISPR proteins

Ge-Fei Hao, Abraham A. Labena, Feng-Biao Guo, 2017, Nucleic Acids Res..

Structural basis of femtomolar inhibitors for acetylcholinesterase subtype selectivity: insights from computational simulations.

Wenchao Yang, Xiao-Lei Zhu, Guangfu Yang, 2013, Journal of molecular graphics & modelling.

Identification, evolution and alternative splicing profile analysis of the splicing factor 30 (SPF30) in plant species

Bei Gao, Moxian Chen, Jianhua Zhang, 2019, Planta.

Rational Design of Highly Potent and Slow-Binding Cytochrome bc1 Inhibitor as Fungicide by Computational Substitution Optimization

Ge-Fei Hao, Guang-Fu Yang, Wei Huang, 2015, Scientific Reports.

Insight into the structural requirements of protoporphyrinogen oxidase inhibitors: Molecular docking and CoMFA of diphenyl ether, isoxazole phenyl, and pyrazole phenyl ether

P. Tranel, F. Dayan, Guangfu Yang, 2013 .

LARMD: integration of bioinformatic resources to profile ligand-driven protein dynamics with a case on the activation of estrogen receptor

Jing-Fang Yang, Guang-Fu Yang, Ge-Fei Hao, 2019, Briefings Bioinform..

Computational Simulations of the Interactions between Acetyl-Coenzyme-A Carboxylase and Clodinafop: Resistance Mechanism Due to Active and Nonactive Site Mutations

Ge-Fei Hao, Xiao-Lei Zhu, Guangfu Yang, 2009, J. Chem. Inf. Model..

ACFIS: a web server for fragment-based drug discovery

Feng-Xu Wu, Ge-Fei Hao, Feng-Biao Guo, 2016, Nucleic Acids Res..

Graph attention convolutional neural network model for chemical poisoning of honey bees' prediction.

Chen-Yang Jia, Guang-Fu Yang, Ge-Fei Hao, 2020, Science bulletin.

Molecular insights into the mechanism of 4‐hydroxyphenylpyruvate dioxygenase inhibition: enzyme kinetics, X‐ray crystallography and computational simulations

C. Zhan, Jia-wei Wu, Wenchao Yang, 2019, The FEBS journal.

Microbiome-mediated signal transduction within the plant holobiont.

Moxian Chen, F. Dini-Andreote, Lei Dai, 2023, Trends in microbiology.

Understanding the mechanism of drug resistance due to a codon deletion in protoporphyrinogen oxidase through computational modeling.

Ge-Fei Hao, Guang-Fu Yang, Li Zhang, 2009, The journal of physical chemistry. B.

CIPDB: a biological structure databank for studying cation-π interactions.

Zhongshi Zhou, Jing-Fang Yang, Fan Wang, 2023, Drug discovery today.

Molecular insights into the mechanism of 4-hydroxyphenylpyruvate dioxygenase inhibition: enzyme kinetics, X-ray crystallography and computational simulations.

C. Zhan, Jia-wei Wu, Wenchao Yang, 2019 .

Cloud 3D-QSAR: a web tool for the development of quantitative structure-activity relationship models in drug discovery

Chen-Yang Jia, Guang-Fu Yang, Ge-Fei Hao, 2020, Briefings Bioinform..

Structural dynamics and determinants of abscisic acid-receptor binding preference in different aggregation states.

Moxian Chen, Jianhua Zhang, Guangfu Yang, 2021, Journal of experimental botany.

Discovery of Novel Pyrazole-Quinazoline-2,4-dione Hybrids as 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors.

Lei Wu, Qiong Chen, Wenchao Yang, 2020, Journal of agricultural and food chemistry.

InsectiPAD: A Web Tool Dedicated to Exploring Physicochemical Properties and Evaluating Insecticide-Likeness of Small Molecules

Chen-Yang Jia, Ge-Fei Hao, Guang-Fu Yang, 2019, J. Chem. Inf. Model..

The Role of Phe82 and Phe351 in Auxin-Induced Substrate Perception by TIR1 Ubiquitin Ligase: A Novel Insight from Molecular Dynamics Simulations

Guangfu Yang, Ge-Fei Hao, 2010, PloS one.

A Phylogenetically Informed Comparison of GH1 Hydrolases between Arabidopsis and Rice Response to Stressors

Zhen Su, Moxian Chen, Jianhua Zhang, 2017, Front. Plant Sci..

Discovery of Next-Generation Tropomyosin Receptor Kinase Inhibitors for Combating Multiple Resistance Associated with Protein Mutation.

Wei Huang, Guang-Fu Yang, Ming-Shu Wang, 2021, Journal of medicinal chemistry.

Development of a Web-Based Laboratory Class to Reduce the Challenges in Teaching Fragment-Based Drug Design

Qiong Chen, Xiao-Lei Zhu, Guangfu Yang, 2020 .

One-Pot Approach to N-Quinolyl 3'/4'-Biaryl Carboxamides by Microwave-Assisted Suzuki-Miyaura Coupling and N-Boc Deprotection.

Shaolin Zhou, Guangfu Yang, Zhihong Huang, 2016, The Journal of organic chemistry.

Pesticide Informatics Platform (PIP): An International Platform for Pesticide Discovery, Residue, and Risk Evaluation.

W. Wang, Long-Can Mei, Xiao Zhang, 2022, Journal of agricultural and food chemistry.

Identification, evolution and alternative splicing profile analysis of the splicing factor 30 (SPF30) in plant species

Bei Gao, Moxian Chen, Jianhua Zhang, 2019, Planta.

Phylogenetic Comparison and Splicing Analysis of the U1 snRNP-specific Protein U1C in Eukaryotes

Moxian Chen, Jianhua Zhang, F. Zhu, 2021, Frontiers in Molecular Biosciences.

Mapping cryptic binding sites of drug targets to overcome drug resistance.

Wei-Cheng Yang, C. Ashby, Ge-Fei Hao, 2023, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Fragment-based drug discovery supports drugging 'undruggable' protein-protein interactions.

Guang-Fu Yang, Zhi-Zheng Wang, Ge-Fei Hao, 2023, Trends in biochemical sciences.

Structure-based methods for predicting target mutation-induced drug resistance and rational drug design to overcome the problem.

Ge-Fei Hao, Guang-Fu Yang, Chang-Guo Zhan, 2012, Drug discovery today.

Computational gibberellin‐binding channel discovery unraveling the unexpected perception mechanism of hormone signal by gibberellin receptor

Ge-Fei Hao, Guangfu Yang, Chang-Guo Zhan, 2013, J. Comput. Chem..

Multiple Simulated Annealing-Molecular Dynamics (MSA-MD) for Conformational Space Search of Peptide and Miniprotein

Ge-Fei Hao, Guang-Fu Yang, Sheng-Gang Yang, 2015, Scientific Reports.

ACFIS 2.0: an improved web-server for fragment-based drug discovery via a dynamic screening strategy

Fan Wang, Zhi-Zheng Wang, Ge-Fei Hao, 2023, Nucleic Acids Res..

Computational mutation scanning and drug resistance mechanisms of HIV-1 protease inhibitors.

Ge-Fei Hao, Guang-Fu Yang, Chang-Guo Zhan, 2010, The journal of physical chemistry. B.

Phylogenetic Comparison and Splicing Analysis of U1 snRNP-specific Protein U1C in Eukaryotes

Moxian Chen, Jianhua Zhang, F. Zhu, 2021 .

Structure-based methods for predicting target mutation-induced drug resistance and rational drug design to overcome the problem.

C. Zhan, Guangfu Yang, Ge-Fei Hao, 2012, Drug discovery today.

Protoporphyrinogen oxidase inhibitor: an ideal target for herbicide discovery.

Guangfu Yang, Sheng-Gang Yang, Y. Zuo, 2011, Chimia.

PIIMS Server: A Web Server for Mutation Hotspot Scanning at the Protein-Protein Interface

Feng-Xu Wu, Ge-Fei Hao, Long-Can Mei, 2021, J. Chem. Inf. Model..

Automated synthesis: current platforms and further needs.

Baoan Song, Zheng Wang, Wei Zhao, 2020, Drug discovery today.

Synthesis and Herbicidal Activity of Triketone-Quinoline Hybrids as Novel 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors.

Qiong Chen, Wenchao Yang, Guangfu Yang, 2015, Journal of agricultural and food chemistry.

Systematic characterization of the branch point binding protein, splicing factor 1, gene family in plant development and stress responses

Moxian Chen, Jianhua Zhang, F. Zhu, 2020, BMC Plant Biology.

Genome-wide identification and functional analysis of the splicing component SYF2/NTC31/p29 across different plant species

Bei Gao, Moxian Chen, Jianhua Zhang, 2018, Planta.

Synthesis and bioevaluation of pyrazole-benzimidazolone hybrids as novel human 4-Hydroxyphenylpyruvate dioxygenase inhibitors.

Wenchao Yang, X. Ruan, Guangfu Yang, 2015, European journal of medicinal chemistry.