V. Tong

发表

Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors.

J. Berger, Gaochao Zhou, Bei B. Zhang, 2009, Bioorganic & medicinal chemistry letters.

Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores.

S. Xu, B. Priest, P. Morissette, 2017, Bioorganic & medicinal chemistry letters.

Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure.

J. Metzger, A. Swensen, M. Forrest, 2016, ACS medicinal chemistry letters.

Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation.

J. Chen, R. Bentley, J. Metzger, 2015, ACS medicinal chemistry letters.

Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators.

M. Altman, X. Fradera, Hongshi Yu, 2021, Journal of medicinal chemistry.

Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability.

T. Fischmann, M. Altman, X. Fradera, 2019, Journal of medicinal chemistry.

The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics.

J. Metzger, K. Maloney, E. Joshi, 2017, Bioorganic & medicinal chemistry letters.

Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.

J. Berger, Gaochao Zhou, Sanjeev Kumar, 2009, Journal of medicinal chemistry.

Fragment-Based Lead Discovery of a Novel Class of Small Molecule Inhibitors of Neuropeptide B/W Receptor Subtype 1 (GPR7).

Zhiqian Guo, N. Hastings, F. Ujjainwalla, 2020, Bioorganic & medicinal chemistry letters.

The discovery of potent antagonists of NPBWR1 (GPR7).

Zhiqian Guo, N. Hastings, F. Ujjainwalla, 2012, Bioorganic & medicinal chemistry letters.

Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors.

J. Berger, Gaochao Zhou, Sanjeev Kumar, 2009, Bioorganic & medicinal chemistry letters.

Discovery of benzimidazole oxazolidinediones as novel and selective nonsteroidal mineralocorticoid receptor antagonists.

J. Lisnock, A. Crespo, Gaochao Zhou, 2015, ACS medicinal chemistry letters.

Structure Overhaul Affords a Potent Purine PI3K delta Inhibitor with Improved Tolerability.

T. Fischmann, X. Fradera, T. Guzi, 2019 .

Discovery of a new series of PI3K-δ inhibitors from Virtual Screening.

M. Augustin, M. Altman, X. Fradera, 2021, Bioorganic & medicinal chemistry letters.

Discovery of imidazole carboxamides as potent and selective CCK1R agonists.

M. Reitman, D. Macneil, S. Qian, 2008, Bioorganic & medicinal chemistry letters.