Karen Rimmer

Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.

Peter D Gibbons, R. Amewu, P. Stocks, 2008, Journal of medicinal chemistry.

Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols.

J. Bacsa, Peter D Gibbons, G. Nixon, 2010, Organic & biomolecular chemistry.

Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.

S. Parapini, D. Taramelli, C. Davis, 2009, Journal of medicinal chemistry.

An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity.

R. Amewu, S. Ward, P. O’Neill, 2008, Bioorganic & medicinal chemistry letters.