Dolores Diaz

Issue Investigation and Practices in Discovery Toxicology

Dolores Diaz, Dylan P. Hartley, Raymond Kemper, 2016 .

Safety Lead Optimization and Candidate Identification: Integrating New Technologies into Decision-Making.

Dolores Diaz, Donna M Dambach, Dinah Misner, 2016, Chemical research in toxicology.

Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid

Dolores Diaz, Deepak Sampath, Hirdesh Uppal, 2015, Toxicology mechanisms and methods.

Applications of cytotoxicity assays and pre-lethal mechanistic assays for assessment of human hepatotoxicity potential.

Dolores Diaz, J. Xu, D. Diaz, 2004, Chemico-biological interactions.

Discovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development.

Dolores Diaz, Jianping Yin, Michael Burkard, 2016, Journal of medicinal chemistry.

An algorithm for evaluating potential tissue drug distribution in toxicology studies from readily available pharmacokinetic parameters.

Dolores Diaz, Brian Dean, Donna M Dambach, 2013, Journal of pharmaceutical sciences.

Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney.

Dolores Diaz, Cleopatra Kozlowski, Donna M Dambach, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

Dolores Diaz, Jun Chen, Deepak Sampath, 2015, Science Translational Medicine.