Keiko Uga

发表

Pharmacological inhibitory profile of TAK‐828F, a potent and selective orally available ROR&ggr;t inverse agonist

M. Sagara, N. Tsuchimori, Satoshi Yamamoto, 2018, Biochemical pharmacology.

Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives.

T. Imada, M. Tawada, M. Shirasaki, 2018, Bioorganic & medicinal chemistry.

Pharmacological effects of TAK-828F: an orally available RORγt inverse agonist, in mouse colitis model and human blood cells of inflammatory bowel disease

T. Kanai, S. Mizuno, N. Tsuchimori, 2019, Inflammation Research.

Pharmacological evaluation of TAK-828F, a novel orally available RORγt inverse agonist, on murine chronic experimental autoimmune encephalomyelitis model

N. Tsuchimori, Akira Shibata, Keiko Igaki, 2019, Journal of Neuroimmunology.

Pharmacological Evaluation of TAK-828F, a Novel Orally Available RORγt Inverse Agonist, on Murine Colitis Model

N. Tsuchimori, Y. Ishimura, Y. Tsukimi, 2019, Inflammation.

Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonis

Biching Sang, T. Imada, R. Skene, 2018, Journal of medicinal chemistry.

Design and Synthesis of Conformationally Constrained RORγt Inverse Agonists

Biching Sang, R. Skene, G. Snell, 2019, ChemMedChem.

Pharmacological Evaluation of TAK-828F, a Novel Orally Available RORγt Inverse Agonist, on Murine Colitis Model

N. Tsuchimori, Y. Ishimura, Y. Tsukimi, 2018, Inflammation.

Novel HDAC6 inhibitors increase tubulin acetylation and rescue axonal transport of mitochondria in a model of Charcot-Marie-Tooth Type 2F.

Mahindra T. Makhija, J. Gilley, R. Adalbert, 2019, ACS chemical neuroscience.

Discovery of orally efficacious RORγt inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds.

Biching Sang, Masaharu Nakayama, R. Skene, 2018, Bioorganic & medicinal chemistry.

Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as selective adenosine A3 antagonists.

Seiji Miwatashi, Y. Imai, S. Ohkawa, 2008, Chemical & pharmaceutical bulletin.

Pharmacological Evaluation of TAK-828F, a Novel Orally Available RORγt Inverse Agonist, on Murine Colitis Model

N. Tsuchimori, Y. Ishimura, Y. Tsukimi, 2018, Inflammation.

Pharmacological effects of TAK-828F: an orally available RORγt inverse agonist, in mouse colitis model and human blood cells of inflammatory bowel disease

T. Kanai, S. Mizuno, N. Tsuchimori, 2019, Inflammation Research.