Ian Tomlinson

发表

Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade.

Jane E. Carpenter, Kyriaki Michailidou, France Labrèche, 2014, Human molecular genetics.

CRISPR-Cas9 Causes Chromosomal Instability and Rearrangements in Cancer Cell Lines, Detectable by Cytogenetic Methods

Ian Tomlinson, I. Tomlinson, C. Green, 2019, The CRISPR journal.

Genetic Predisposition to In Situ and Invasive Lobular Carcinoma of the Breast

Julian Peto, Matthias W. Beckmann, Peter A. Fasching, 2014, PLoS genetics.

Identification of Novel Genetic Markers of Breast Cancer Survival

Peter Kraft, Nazneen Rahman, Janet A. Dunn, 2015, Journal of the National Cancer Institute.

Cancer: evolution within a lifetime.

Charles Swanton, Ian Tomlinson, Nicholas McGranahan, 2014, Annual review of genetics.

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Michael Jones, Peter Kraft, Arnaud Droit, 2017, Nature Genetics.

Chromatin organisation and cancer prognosis: a pan-cancer study

Marco Novelli, Fritz Albregtsen, Ian Tomlinson, 2018, The Lancet. Oncology.

Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation

Matthias W. Beckmann, Peter A. Fasching, Simon S. Cross, 2016, American journal of human genetics.

Genetic prognostic and predictive markers in colorectal cancer

Charles Swanton, Ian Tomlinson, Rachel Midgley, 2011, Nature Reviews Cancer.

19p13.1 is a triple-negative-specific breast cancer susceptibility locus.

Daniel J. Park, Julian Peto, Kamila Czene, 2012, Cancer research.

Clinical applicability and cost of a 46-gene panel for genomic analysis of solid tumours: Retrospective validation and prospective audit in the UK National Health Service

Carme Camps, Denis Talbot, Sarah Wordsworth, 2017, PLoS medicine.

MLH1 germline epimutations as a factor in hereditary nonpolyposis colorectal cancer.

Megan Hitchins, Rodney Scott, Ian Tomlinson, 2005, Gastroenterology.

Evidence for a colorectal cancer susceptibility locus on chromosome 3q21-q24 from a high-density SNP genome-wide linkage scan.

Ian Tomlinson, Anneke Lucassen, Elli Papaemmanuil, 2006, Human molecular genetics.

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis

Gary D. Bader, Christine L. Clarke, Gary D Bader, 2020, Nature Communications.

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Wei Lu, Wei Zheng, Mads Thomassen, 2013, Nature Genetics.

BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers.

Dong Liang, Patrick Neven, Harvey Risch, 2016, Journal of the National Cancer Institute.

Prognostic and Predictive Biomarkers in Resected Colon Cancer: Current Status and Future Perspectives for Integrating Genomics into Biomarker Discovery

Sabine Tejpar, Levi Garraway, Andrea Bild, 2010, The oncologist.

Target gene mutational pattern in Lynch syndrome colorectal carcinomas according to tumour location and germline mutation

Raquel Seruca, Rui Henrique, Isabel Veiga, 2015, British Journal of Cancer.

Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis

Darryl Shibata, Ian Tomlinson, Sakari Knuutila, 1997, Nature Genetics.

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling

Esko Ukkonen, Jussi Taipale, Mikko Turunen, 2009, Nature Genetics.

The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

Ian Tomlinson, Andrew Rowan, Susan Clark, 1999, Nature Medicine.

Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden

Peter Donnelly, Gil McVean, Paolo Piazza, 2014, Nature Communications.

Breast cancer risk variants at 6 q 25 display different phenotype associations and regulate ESR 1 , RMND 1 and CCDC 170

Wei Zheng, Mads Thomassen, Nicholas A. Sinnott-Armstrong, 2016 .

'Toxgnostics': an unmet need in cancer medicine

Ian Tomlinson, Rachel Kerr, Claire Palles, 2014, Nature Reviews Cancer.

A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk

Oliver Sieber, Julian Peto, Jean-Baptiste Cazier, 2007, Nature Genetics.

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

Ian Tomlinson, Mike Fried, N. Hogg, 2009, Nature Medicine.

Putative cis-regulatory drivers in colorectal cancer

Emmanouil T. Dermitzakis, Pedro G. Ferreira, Ian Tomlinson, 2014, Nature.

Comparison of 6q25 Breast Cancer Hits from Asian and European Genome Wide Association Studies in the Breast Cancer Association Consortium (BCAC)

Patrick Neven, Hui Zhao, Nazneen Rahman, 2012, PloS one.

Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives.

Julian Peto, Ian Tomlinson, Olivia Fletcher, 2006, Human molecular genetics.

Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy

Christiana Kartsonaki, Jean-Baptiste Cazier, Francesca Buffa, 2016, Nature Communications.

Rare genetic variants and the risk of cancer.

Ian Tomlinson, W. Bodmer, I. Tomlinson, 2010, Current opinion in genetics & development.

A panoply of errors: polymerase proofreading domain mutations in cancer

Ian Tomlinson, Tjalling Bosse, Stephen E. Kearsey, 2016, Nature Reviews Cancer.

Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium.

Michael Jones, Nazneen Rahman, Michael Bremer, 2011, Human molecular genetics.

A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46,450 cases and 42,461 controls from the breast cancer association consortium.

Julian Peto, Kyriaki Michailidou, Thomas Brüning, 2014, Human molecular genetics.

Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer

Patrick Neven, Peter Kraft, Nazneen Rahman, 2015 .

Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers.

Wei Lu, Päivi Heikkilä, Peter Kraft, 2013, American journal of human genetics.

Genome-wide association studies identify four ER negative–specific breast cancer risk loci

Patrick Neven, Michael Jones, Wei Lu, 2013, Nature Genetics.

Five endometrial cancer risk loci identified through genome-wide association analysis

Hui Zhao, Mark McEvoy, Julian Peto, 2016, Nature Genetics.

Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study

Patrick Neven, Chiun-Sheng Huang, Julian Peto, 2014, Breast Cancer Research.

Germline mutations in the proof-reading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

Peter Donnelly, Jonathan Grimes, Gilean McVean, 2012, Nature Genetics.

A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer

Jane E. Carpenter, Peter Kraft, Gary K. Chen, 2011, Nature Genetics.

The Mendelian colorectal cancer syndromes

Ian Tomlinson, I. Tomlinson, 2015, Annals of clinical biochemistry.

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

Oliver Sieber, Julian Peto, Jean-Baptiste Cazier, 2007, Nature Genetics.

PALB2,CHEK2 and ATM rare variants and cancer risk: Data from COGS

Dong Liang, Jane E. Carpenter, Peter Kraft, 2016 .

Germline and somatic polymerase ε and δ mutations define a new class of hypermutated colorectal and endometrial cancers

Ian Tomlinson, I. Tomlinson, Sarah Briggs, 2013, The Journal of pathology.

POLE mutations in families predisposed to cutaneous melanoma

Nicholas G. Martin, Ian Tomlinson, Grant W. Montgomery, 2015, Familial Cancer.

Deep learning for prediction of colorectal cancer outcome: a discovery and validation study

Marco Novelli, Fritz Albregtsen, Ian Tomlinson, 2020, The Lancet.

11q13 is a susceptibility locus for hormone receptor positive breast cancer

Patrick Neven, Michael Jones, Michael Bremer, 2012, Human mutation.

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas

Peter Donnelly, Jonathan Grimes, Gilean McVean, 2013, Nature Genetics.

Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers.

Michael Jones, Julian Peto, Thomas Brüning, 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer.

Harvey Risch, Peter Kraft, Mark McEvoy, 2016, Human molecular genetics.

Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1.

Wei Lu, Nina Ditsch, Julian Peto, 2013, American journal of human genetics.

Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency

Florian Engert, Joachim Weischenfeldt, Jan Smida, 2015, Nature Communications.

Genetic prognostic and predictive markers in colorectal cancer

Charles Swanton, Ian Tomlinson, Rachel Midgley, 2009, Nature Reviews Cancer.

Molecular and Cellular Pathobiology Expression Profiling in Progressive Stages of Fumarate- Hydratase Deficiency: the Contribution of Metabolic Changes to Tumorigenesis

Ian Tomlinson, Yuen-Li Chung, L. Aaltonen, 2022 .

Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

Alison P. Klein, Yan Zhang, Peter Kraft, 2019, bioRxiv.

Identification of nine new susceptibility loci for endometrial cancer

Peter Kraft, Mark McEvoy, Julian Peto, 2018, Nature Communications.

Detecting repeated cancer evolution from multi-region tumor sequencing data

Giulio Caravagna, Guido Sanguinetti, Daniele Ramazzotti, 2018, Nature Methods.

Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

Alison P. Klein, Peter Kraft, Florence Demenais, 2020, Nature Communications.

Genome-wide association analysis identifies three new breast cancer susceptibility loci

Michael Jones, Nazneen Rahman, Daniel J. Park, 2012, Nature Genetics.

Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog

Ian Tomlinson, W. Bodmer, I. Tomlinson, 1999, Nature medicine.