Hong Yong

发表

Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.

K. Longenecker, J. Segreti, H. Sham, 2006, Journal of medicinal chemistry.

Discovery and SAR of 4-Aminopyrrolidine-2-carboxylic Acid Correctors of CFTR for the Treatment of Cystic Fibrosis.

A. Bogdan, A. Swensen, Ashvani K. Singh, 2022, Bioorganic & medicinal chemistry letters.

Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

K. Longenecker, H. Sham, R. Fryer, 2006, Journal of medicinal chemistry.

Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors.

Vincent S Stoll, K. Longenecker, V. Stoll, 2006, Biochemistry.

Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis.

A. Bogdan, C. Tse, A. Swensen, 2018, Journal of medicinal chemistry.

Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae.

N. Soni, R. Clark, K. Marsh, 2005, Bioorganic & Medicinal Chemistry Letters.

Synthesis and antibacterial activity of novel bifunctional macrolides.

I. Akritopoulou‐Zanze, S. Djurić, G. Stone, 2004, Bioorganic & medicinal chemistry letters.

Design, Synthesis and Structure—Activity Relationships of 6-O-Arylpropargyl Diazalides with Potent Activity Against Multidrug-Resistant Streptococcus Pneumoniae.

N. Soni, R. Clark, K. Marsh, 2005 .

Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis.

A. Bogdan, C. Tse, A. Swensen, 2019, ACS medicinal chemistry letters.

Synthesis and biological evaluation of heterocycle containing adamantane 11β-HSD1 inhibitors

Jyoti R. Patel, H. Sham, D. Beno, 2006 .

Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens.

Suoming Zhang, S. Zhang, M. Mitten, 2001, Journal of medicinal chemistry.