Yunxin Cai

Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine.

Maree T. Smith, A. Kuo, S. Ghassabian, 2020, European journal of pharmacology.

[Dmt(1)]DALDA analogues modified with tyrosine analogues at position 1.

P. Schiller, N. N. Chung, Zhen Chen, 2016, Bioorganic & medicinal chemistry letters.

Endomorphin analogues with mixed μ-opioid (MOP) receptor agonism/δ-opioid (DOP) receptor antagonism and lacking β-arrestin2 recruitment activity.

Maree T. Smith, Y. Sasaki, A. Ambo, 2014, Bioorganic & medicinal chemistry.

CYX-5, a G-protein biassed MOP receptor agonist, DOP receptor antagonist and KOP receptor agonist, evokes constipation but not respiratory depression relative to morphine in rats

Maree T. Smith, A. Kuo, S. Ghassabian, 2023, Pharmacological Reports.

In Vitro Assessment of the Metabolic Stability of Two Novel Endomorphin-2 Analogs, CYX-5 and CYX-6, in Rat Liver Microsomes

Maree T. Smith, A. Kuo, S. Ghassabian, 2023, European Journal of Drug Metabolism and Pharmacokinetics.