T. Ohgiya

发表

Discovery of Clinical Candidate 2-(4-(2-((1 H-Benzo[ d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)- N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide Hydrochloride [K-604], an Aqueous-Soluble Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor.

Y. Tsunenari, Y. Yoshinaka, K. Shibuya, 2018, Journal of medicinal chemistry.

A facile method for converting alcohol to thioether and its application in the synthesis of a novel GPR119 agonist

Tomoaki Koshizawa, K. Shibuya, Y. Yamazaki, 2015 .

DBU-Promoted Elimination Reactionsof Vicinal Dibromoalkanes Mediated by Adjacent O-Functional Groups,and Applications to the Synthesis of Biologically ActiveNatural Products

S. Nishiyama, Noriki Kutsumura, T. Ohgiya, 2008 .

Efficient Synthesis of Propargylic Ethers under the DBU Conditions and Its Application to Natural Products Synthesis

T. Yokoyama, S. Nishiyama, Noriki Kutsumura, 2007 .

1,2-Dibromoalkanes into alkynes by elimination reaction under DBU conditions and their application to total synthesis of sapinofuranone B

T. Yokoyama, S. Nishiyama, Noriki Kutsumura, 2006 .

Total Synthesis of (+)-Tanikolide, Using Regioselective Elimination of a Vicinal Dibromoalkane

Kensuke Nakamura, S. Nishiyama, T. Ohgiya, 2005 .

Total synthesis of (+)-tanikolide, a toxic and antifungal δ-lactone, utilizing bromoalkene intermediates conveniently synthesized from vicinal dibromoalkane by regioselective elimination

S. Nishiyama, T. Ohgiya, 2004 .

Synthesis of (-)-Tuliparin B Utilizing 2-Bromo-1-alkenes Conveniently Synthesized from the 3-O-Substituted 1,2-Dibromoalkane System by Regioselective Elimination

S. Nishiyama, T. Ohgiya, 2004 .

Conversion of 3-O-Substituted 1,2-Dibromoalkanes into 2-Bromo-1-alkenes by the Selective Elimination: Its Application to Total Synthesis of 12-Oxygenated Tremetones

S. Nishiyama, T. Ohgiya, 2004 .

A simple deprotection of triflate esters of phenol derivatives

S. Nishiyama, T. Ohgiya, 2004 .

Synthesis and bioactivities of novel pyridazine derivatives: inhibitors of interleukin-1 beta (IL-1beta) production.

T. Aoki, H. Shigyo, T. Matsuda, 2001, Bioorganic & medicinal chemistry letters.

Oxetanocin-oxetanose chemistry : lewis acid promoted glycosidations of the D-erythrooxetanose derivatives

T. Takita, S. Nishiyama, S. Yamamura, 1992 .

Optimization of a novel series of potent and orally bioavailable GPR119 agonists.

Tomoaki Koshizawa, Tomoaki Fukuda, T. Morimoto, 2017, Bioorganic & medicinal chemistry letters.

A Simple Deprotection of Triflate Esters of Phenol Derivatives.

S. Nishiyama, T. Ohgiya, 2004 .

Total synthesis of (−)-5,6-seco-germacrane lactone

Takao Saito, S. Nishiyama, Noriki Kutsumura, 2015 .

A Practical Synthesis of Novel Rho‐Kinase Inhibitor, (S)‐4‐Fluoro‐5‐(2‐methyl‐1,4‐diazepan‐1‐ylsulfonyl)isoquinoline.

K. Shibuya, T. Ohgiya, Masayuki Masumoto, 2011 .

New CETP inhibitor K-312 reduces PCSK9 expression: a potential effect on LDL cholesterol metabolism.

Sasha A. Singh, M. Aikawa, H. Yamazaki, 2015, American journal of physiology. Endocrinology and metabolism.

Three derivatives of 4-fluoro-5-sulfonylisoquinoline.

S. Ohba, K. Shibuya, T. Ohgiya, 2012, Acta crystallographica. Section C, Crystal structure communications.

Discovery of novel spiro[chromane-2,4'-piperidine] derivatives as potent and orally bioavailable G-protein-coupled receptor 119 agonists.

Tomoaki Koshizawa, Tomoaki Fukuda, T. Morimoto, 2018, Bioorganic & medicinal chemistry letters.

A Practical Synthesis of (S)-tert-Butyl 3-Methyl-1,4-diazepane-1-carboxylate, the Key Intermediate of Rho–Kinase Inhibitor K-115

K. Shibuya, Akiyasu Kouketsu, T. Ohgiya, 2012 .

Syntheses and pharmacokinetic evaluations of four metabolites of 2-(4-(2-((1H-benzo[d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)-N-(6-methyl-2,4-bis-(methylthio)pyridin-3-yl)acetamide hydrochloride [K-604], an acyl-CoA:cholesterol O-acyltransferase-1 inhibitor.

Y. Tsunenari, K. Shibuya, T. Miura, 2020, Bioorganic & medicinal chemistry.