Ioanna Deni

发表

Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum.

E. Winzeler, D. Fidock, M. Phillips, 2021, Journal of medicinal chemistry.

Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance

M. Eppstein, P. Roepe, D. Fidock, 2022, PLoS pathogens.

The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance

E. Winzeler, K. Chibale, E. Istvan, 2021, Cell Chemical Biology.

P. falciparum K13 mutations present varying degrees of artemisinin resistance and reduced fitness in African parasites

P. Rosenthal, D. Fidock, L. Ross, 2021, bioRxiv.

Genomic and Genetic Approaches to Studying Antimalarial Drug Resistance and Plasmodium Biology.

D. Fidock, John Okombo, Mariko Kanai, 2021, Trends in parasitology.

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

D. Fidock, L. Ross, F. Nosten, 2021, eLife.

Plasmodium falciparum K13 mutations in Africa and Asia present varying degrees of artemisinin resistance and an elevated fitness cost in African parasites

P. Rosenthal, D. Fidock, L. Ross, 2021, bioRxiv.

Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome

H. Zhang, M. Bogyo, D. Fidock, 2023, Cell chemical biology.

Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome

E. Winzeler, L. Tilley, D. Fidock, 2021, Proceedings of the National Academy of Sciences.

Safety, pharmacokinetics, and antimalarial activity of the novel triaminopyrimidine ZY-19489: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study, pilot food-effect study, and volunteer infection study.

J. McCarthy, D. Fidock, J. Möhrle, 2022, The Lancet. Infectious diseases.

Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.

David M. Shackleford, E. Winzeler, P. Rathod, 2021, Journal of medicinal chemistry.