Rui-Qin Liu

发表

Potent and selective aggrecanase inhibitors containing cyclic P1 substituents.

R. Magolda, J. Trzăskos, M. Covington, 2003, Bioorganic & medicinal chemistry letters.

A microplate assay specific for the enzyme aggrecanase.

G. Davis, R. Copeland, J. Trzăskos, 2003, Analytical biochemistry.

Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats.

G. Feuerstein, R. Taub, C. Decicco, 2004, Molecular pharmacology.

Discovery and lead optimization of a novel series of CC chemokine receptor 1 (CCR1)-selective piperidine antagonists via parallel synthesis.

J. Chen, S. Mandlekar, C. Cavallaro, 2012, Journal of medicinal chemistry.

α2-Macroglobulin Is a Novel Substrate for ADAMTS-4 and ADAMTS-5 and Represents an Endogenous Inhibitor of These Enzymes*

A. Wittwer, M. Tortorella, A. Malfait, 2004, Journal of Biological Chemistry.

Sites of Aggrecan Cleavage by Recombinant Human Aggrecanase-1 (ADAMTS-4)*

T. Burn, M. Tortorella, E. Arner, 2000, The Journal of Biological Chemistry.

Characterization of human aggrecanase 2 (ADAM-TS5): substrate specificity studies and comparison with aggrecanase 1 (ADAM-TS4).

T. Burn, R. Newton, M. Tortorella, 2002, Matrix biology : journal of the International Society for Matrix Biology.

Membrane localization of beta-amyloid 1-42 in lysosomes: a possible mechanism for lysosome labilization.

Du Feng, S. Ji, S. Sui, 2010, The Journal of biological chemistry.

Both 5-arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones and 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones are light-dependent tumor necrosis factor-alpha antagonists.

P. Scherle, J. Trzăskos, A. Tebben, 2003, Bioorganic & medicinal chemistry letters.

Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

Andrew Tebben, A. Tebben, C. Decicco, 2007, Bioorganic & medicinal chemistry letters.

Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

Soong-Hoon Kim, W. Pitts, M. Covington, 2007, Bioorganic & medicinal chemistry letters.

Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-α

D. Underwood, P. Domaille, K. Ramnarayan, 2001, Proceedings of the National Academy of Sciences of the United States of America.

α,β-Cyclic-β-benzamido hydroxamic acids: Novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-α converting enzyme (TACE)

David D. Christ, K. Vaddi, M. Covington, 2008 .

Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors.

Zelda R Wasserman, J. Trzăskos, K. Vaddi, 2008, Bioorganic & medicinal chemistry letters.

Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1' substituents.

J. Trzăskos, K. Vaddi, M. Covington, 2008, Bioorganic & medicinal chemistry letters.

Conversion of potent MMP inhibitors into selective TACE inhibitors.

Bryan W King, B. W. King, M. Covington, 2006, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Evaluation of Benzothiadiazepine Hydroxamates as Selective Tumor Necrosis Factor-α Converting Enzyme Inhibitors

S. Mandlekar, K. D. Hardman, R. Magolda, 2003 .

Synthesis and structure-activity relationship of a novel sulfone series of TNF-alpha converting enzyme inhibitors.

Xiaohua He, John Roderick, J. Trzăskos, 2004, Bioorganic & medicinal chemistry letters.

Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents.

J. Trzăskos, K. Vaddi, M. Covington, 2008, Bioorganic & medicinal chemistry letters.

Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

John Roderick, Xiao-tao Chen, M. Covington, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and structure–activity relationship of a novel, non-hydroxamate series of TNF-α converting enzyme inhibitors

A. Tebben, B. W. King, M. Covington, 2007 .

A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1' group for the beta-amino hydroxamic acid derived TACE inhibitors.

J. Trzăskos, Xiao-tao Chen, K. Vaddi, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and structure–activity relationship of a novel, achiral series of TNF-α converting enzyme inhibitors

J. Trzăskos, T. Maduskuie, B. W. King, 2004 .

Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 1: lead identification.

Xiaohua He, John Roderick, R. Magolda, 2003, Bioorganic & medicinal chemistry letters.

Discovery of N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

R. Magolda, J. Trzăskos, M. Covington, 2003, Bioorganic & medicinal chemistry letters.

Pharmacologic and genetic manipulation of MMP-2 and -9 affects retinal neovascularization in rodent models of OIR.

J. Penn, G. Mccollum, J. Duan, 2007, Investigative ophthalmology & visual science.

Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors.

S. Mandlekar, K. D. Hardman, R. Magolda, 2003, Journal of medicinal chemistry.

Potent P1' biphenylmethyl substituted aggrecanase inhibitors.

M. Covington, C. Decicco, R. Wexler, 2002, Bioorganic & medicinal chemistry letters.

Cellular Internalization of Exosomes Occurs Through Phagocytosis

Qiang Zhou, X. Bai, Qiang Zhou, 2010, Traffic.

Inhibition of Tumor Necrosis Factor-α-Converting Enzyme by a Selective Antagonist Protects Brain from Focal Ischemic Injury in Rats

Lin Xu, G. Feuerstein, R. Taub, 2004 .

Discovery and synthesis of cyclohexenyl derivatives as modulators of CC chemokine receptor 2 activity.

Michael A. Galella, J. Barrish, M. Cvijic, 2016, Bioorganic & medicinal chemistry letters.

Cloning and Characterization of ADAMTS11, an Aggrecanase from the ADAMTS Family*

R. Wynn, R. Copeland, Y. Itoh, 1999, The Journal of Biological Chemistry.

Discovery of γ-Lactam Hydroxamic Acids as Selective Inhibitors of Tumor Necrosis Factor α Converting Enzyme: Design, Synthesis, and Structure−Activity Relationships

Chen Lihua, Zelda R. Wasserman, Karl D. Hardman, 2002 .

Sultam hydroxamates as novel matrix metalloproteinase inhibitors.

K. D. Hardman, J. Trzăskos, M. Covington, 2004, Journal of medicinal chemistry.

Induction of aggrecanase 1 (ADAM-TS4) by interleukin-1 occurs through activation of constitutively produced protein.

P. Scherle, Gengjie Yang, R. Newton, 2003, Arthritis and rheumatism.

The Thrombospondin Motif of Aggrecanase-1 (ADAMTS-4) Is Critical for Aggrecan Substrate Recognition and Cleavage*

T. Burn, M. Tortorella, E. Arner, 2000, The Journal of Biological Chemistry.

Comparison of Primary Keloid Fibroblast Cultivation Methods and the Characteristics of Fibroblasts Cultured from Keloids, Keloid-surrounding Tissues, and Normal Skin Tissues

Lianbo Zhang, Haiyan Qin, Guang Zhang, 2021 .

Design, Synthesis, and Structure−Activity Relationships of Macrocyclic Hydroxamic Acids That Inhibit Tumor Necrosis Factor α Release in Vitro and in Vivo

Chen Lihua, Robert A. Copeland, David J. Nelson, 2001 .

Inhibition of ADAM-TS4 and ADAM-TS5 Prevents Aggrecan Degradation in Osteoarthritic Cartilage*

M. Tortorella, A. Malfait, Rui-Qin Liu, 2002, The Journal of Biological Chemistry.

Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe

M. Favata, J. Trzăskos, A. Tebben, 2007, Proceedings of the National Academy of Sciences.

Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 2: lead optimization.

R. Magolda, J. Trzăskos, K. Vaddi, 2004, Bioorganic & medicinal chemistry letters.

Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

J. Trzăskos, W. Marshall, K. Vaddi, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of succinoyl-caprolactam γ-secretase inhibitors

Marcie A. Glicksman, M. Glicksman, D. Seiffert, 2006 .

Pharmacokinetics and Pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-Amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a Potent and Selective Inhibitor of Tumor Necrosis Factor α-Converting Enzyme in Rodents, Dogs, Chimpanzees, and Humans

J. Trzăskos, T. Maduskuie, C. Garner, 2007, Drug Metabolism and Disposition.

Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-alpha converting enzyme.

M. Covington, C. Decicco, J. Duan, 2005, Bioorganic & medicinal chemistry letters.