Irena Brzak

ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157

A. Kaykas, Kathleen A. Worringer, G. Elain, 2017, Neuroscience Letters.

Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae

J. Chhatwal, M. Staufenbiel, M. Jucker, 2022, Nature Communications.

Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice

D. Theil, M. Jucker, R. Kreutzer, 2016, Scientific Reports.

Sustained TREM2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer’s disease

F. Gasparini, Ivan Galimberti, U. Naumann, 2021, bioRxiv.

Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor–treated APP transgenic mice

M. Staufenbiel, D. Theil, R. Kreutzer, 2016, Neurobiology of Aging.

Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second-Generation Amyloid-β Mouse Model

N. Albert, A. Rominger, J. Herms, 2019, The Journal of Nuclear Medicine.