KeWei Wang

发表

Interactions of KChIP4a and its mutants with Ca2+ or Kv4.3 N-terminus by affinity capillary electrophoresis.

Xiaomei Ling, Meina Li, Jianmei Zhang, 2014, Analytical biochemistry.

Selective inhibition of TRPM2 channel by two novel synthesized ADPR analogues

Lihe Zhang, Meng Li, L. Zhang, 2017, Chemical biology & drug design.

Exome sequencing reveals mutations in TRPV3 as a cause of Olmsted syndrome.

Ruoyu Li, Haizhen Yang, L. Guan, 2012, American journal of human genetics.

A pivotal role for the activation of TRPV3 channel in itch sensations induced by the natural skin sensitizer carvacrol

Ning-ning Wei, Gong-xin Wang, KeWei Wang, 2017, Acta Pharmacologica Sinica.

Pharmacological characterization of JWX-A0108 as a novel type I positive allosteric modulator of α7 nAChR that can reverse acoustic gating deficits in a mouse prepulse inhibition model

W. Lu, Qin Gao, Ning-ning Wei, 2018, Acta Pharmacologica Sinica.

Natural product incarvillateine aggravates epileptic seizures by inhibiting GABAA currents.

Yanxing Jia, Gongxin Wang, Yu Zhang, 2019, European journal of pharmacology.

Crystal structure of the N-terminal ankyrin repeat domain of TRPV3 reveals unique conformation of finger 3 loop critical for channel function

Kewei Wang, Rongguang Zhang, S. Ye, 2013, Protein & Cell.

Deficiency of anti-inflammatory cytokine IL-4 leads to neural hyperexcitability and aggravates cerebral ischemia–reperfusion injury

Yan Song, Zhuo Huang, Jingliang Zhang, 2020, Acta pharmaceutica Sinica. B.

Two N-Terminal Domains of Kv4 K+ Channels Regulate Binding to and Modulation by KChIP1

K. Rhodes, P. Chanda, W. Somers, 2004, Neuron.

A rapid-response and near-infrared fluorescent probe for imaging of nitroxyl in living cells.

Zhen Qiao, Hongyi Zhang, Ning-ning Wei, 2020, Talanta.

Inhibition of temperature-sensitive TRPV3 channel by two natural isochlorogenic acid isomers for alleviation of dermatitis and chronic pruritus

Han Wu, Canyang Niu, Xiaoying Sun, 2021, Acta pharmaceutica Sinica. B.

Selective activation of TRPA1 ion channels by nitrobenzene skin sensitizers DNFB and DNCB

Kewei Wang, Han Wu, Canyang Niu, 2021, The Journal of biological chemistry.

Antipruritic Effect of Natural Coumarin Osthole through Selective Inhibition of Thermosensitive TRPV3 Channel in the Skin

Kewei Wang, Qin Gao, Ning-ning Wei, 2018, Molecular Pharmacology.

The Mpro structure-based modifications of ebselen derivatives for improved antiviral activity against SARS-CoV-2 virus

Kewei Wang, Zhen Qiao, Hongyi Zhang, 2021, Bioorganic Chemistry.

Intracellular Proton-mediated Activation of TRPV3 Channels Accounts for the Exfoliation Effect of α-Hydroxyl Acids on Keratinocytes*

Fan Yang, Jie Zheng, Xu Cao, 2012, The Journal of Biological Chemistry.

The microRNA miR-124 suppresses seizure activity and regulates CREB1 activity

J. Li, Jing Luo, Xuefeng Wang, 2016, Expert Reviews in Molecular Medicine.

Peptide hormone ghrelin enhances neuronal excitability by inhibition of Kv7/KCNQ channels

Junxia Xie, Hong Jiang, Limin Shi, 2013, Nature Communications.

MicroRNA-124 suppresses growth of human hepatocellular carcinoma by targeting STAT3.

Yuanyuan Cui, Ju-feng Zhang, Xupeng Yue, 2013, Biochemical and biophysical research communications.

Inhibition of Ca2+‐activated chloride channel ANO1 suppresses ovarian cancer through inactivating PI3K/Akt signaling

Jianjun Gao, Sushan Zhang, Congxiao Zhang, 2019, International journal of cancer.

The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?

Kewei Wang, Yani Liu, Zongtao Liu, 2020, Acta pharmaceutica Sinica. B.

A specialized pore turret in the mammalian cation channel TRPV1 is responsible for distinct and species-specific heat activation thresholds

Kewei Wang, Jie Zheng, Shilong Yang, 2020, The Journal of Biological Chemistry.

Inhibition of Ca(2+)-activated Cl(-) channel ANO1/TMEM16A expression suppresses tumor growth and invasiveness in human prostate carcinoma.

Min Lu, Yi Huang, Baogang Liu, 2012, Cancer letters.

Inhibition of Calcium-Activated Chloride Channel ANO1/TMEM16A Suppresses Tumor Growth and Invasion in Human Lung Cancer

Min Lu, Lizhao Guan, Linghan Jia, 2015, PloS one.

NpgRJ_Nn_1822 32..39

J. Chai, Qun Liu, Q. Hao, 2006 .

Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits

J. Chai, Kewei Wang, Qun Liu, 2007, Nature Neuroscience.

Inhibition of Nav1.7 channel by a novel blocker QLS-81 for alleviation of neuropathic pain

Kewei Wang, Jing Wang, Deng-Qi Xue, 2021, Acta Pharmacologica Sinica.

Heteromeric Heat-sensitive Transient Receptor Potential Channels Exhibit Distinct Temperature and Chemical Response*

M. Zhu, Yuan-yuan Cui, Fan Yang, 2011, The Journal of Biological Chemistry.

Thermosensitive TRP channel pore turret is part of the temperature activation pathway

Fan Yang, Yuan-yuan Cui, Fan Yang, 2010, Proceedings of the National Academy of Sciences.

A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1

V. Yarov-Yarovoy, Fan Yang, Jie Zheng, 2015, Nature Communications.

The Ca2+-Permeable Cation Transient Receptor Potential TRPV3 Channel: An Emerging Pivotal Target for Itch and Skin Diseases

Gongxin Wang, KeWei Wang, 2017, Molecular Pharmacology.

The Ca 2 1 -Permeable Cation Transient Receptor Potential TRPV3 Channel: An Emerging Pivotal Target for Itch and Skin Diseases

Gongxin Wang, KeWei Wang, 2017 .

Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations

V. Yarov-Yarovoy, Yuan-yuan Cui, Fan Yang, 2012, The Journal of general physiology.

Pharmacological Activation of Neuronal Voltage-Gated Kv7/KCNQ/M-Channels for Potential Therapy of Epilepsy and Pain.

Yani Liu, KeWei Wang, Xiling Bian, 2021, Handbook of experimental pharmacology.

Exploiting the Diversity of Ion Channels: Modulation of Ion Channels for Therapeutic Indications.

Yani Liu, KeWei Wang, 2019, Handbook of experimental pharmacology.

Inhibition of calcium-activated chloride channel ANO1 suppresses proliferation and induces apoptosis of epithelium originated cancer cells

Jianjun Gao, Kewei Wang, Jian Gao, 2016, Oncotarget.

Pharmacological characterization of JWX-A0108 as a novel type I positive allosteric modulator of α7 nAChR that can reverse acoustic gating deficits in a mouse prepulse inhibition model

W. Lu, Qin Gao, Ning-ning Wei, 2018, Acta Pharmacologica Sinica.

Synthesis and Biological Evaluation of Novel Triazine Derivatives as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors.

Jing Wang, L. Zhang, Jian Gao, 2021, Journal of medicinal chemistry.

Design and Synthesis of Novel Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in Mice.

Jing-shu Tang, Laichun Luo, Tao-yi Yang, 2019, Journal of Medicinal Chemistry.

Chemical conversion of nicotinamide into type I positive allosteric modulator of α7 nAChRs.

Xin Li, Wen-Xue Xie, KeWei Wang, 2019, Bioorganic & medicinal chemistry letters.

The visualization of hERG channels in living cells via a fluorescent probe regulated by the synergy between solvatochromism and molecular rotation based on simple targeting of the group 4-benzylaniline.

Kewei Wang, Zhen Qiao, Hongyi Zhang, 2019, Chemical communications.

A highly sensitive and responsive fluorescent probe based on 6-azide-chroman dye for detection and imaging of hydrogen sulfide in cells.

KeWei Wang, Zhen Qiao, Hongyi Zhang, 2019, Talanta.

Pharmacological Characterization of H05, a Novel Serotonin and Noradrenaline Reuptake Inhibitor with Moderate 5-HT2A Antagonist Activity for the Treatment of Depression

Q. Guo, Yani Liu, Xiangqing Xu, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Prefrontal inhibition of neuronal Kv7 channels enhances prepulse inhibition of acoustic startle reflex and resistance to hypofrontality

Kewei Wang, Jing Wang, Wenwen Yu, 2020, British journal of pharmacology.

Crystal structure of the N-terminal ankyrin repeat domain of TRPV3 reveals unique conformation of finger 3 loop critical for channel function

Rongguang Zhang, S. Ye, D. Shi, 2013, Protein & Cell.

Divalent cations potentiate TRPV1 channel by lowering the heat activation threshold

Linlin Ma, Fan Yang, Jie Zheng, 2014, The Journal of general physiology.

Divalent cations activate TRPV1 through promoting conformational change of the extracellular region

Linlin Ma, Fan Yang, Jie Zheng, 2014, The Journal of general physiology.

Evodiamine Lowers Blood Lipids by Up-Regulating the PPARγ/ABCG1 Pathway in High-Fat-Diet-Fed Mice.

A. Atanasov, E. Heiss, V. Dirsch, 2021, Journal of natural products.

Pharmacological Activation of Thermo–Transient Receptor Potential Vanilloid 3 Channels Inhibits Hair Growth by Inducing Cell Death of Hair Follicle Outer Root Sheath

Yani Liu, Gongxin Wang, Xiaoying Sun, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Pharmacological activation of thermoTRPV3 channels inhibits hair growth by inducing cell death of hair follicle outer root sheath

Yani Liu, Gongxin Wang, Xiaoying Sun, 2019 .

Natural Piperine Improves Lipid Metabolic Profile of High-Fat Diet-Fed Mice by Upregulating SR-B1 and ABCG8 Transporters.

Limei Wang, Congxiao Zhang, Xingming Hou, 2021, Journal of natural products.

Detection of Lipase Activity in Cells by a Fluorescent Probe Based on Formation of Self-Assembled Micelles

Zhen Qiao, Hongyi Zhang, Yanru Zhang, 2020, iScience.

Activation of neuronal Kv7/KCNQ/M-channels by the opener QO58-lysine and its anti-nociceptive effects on inflammatory pain in rodents

Fan Zhang, Yan Song, Gang Li, 2016, Acta Pharmacologica Sinica.

Identification of a Tetrameric Assembly Domain in the C Terminus of Heat-activated TRPV1 Channels*

Fan Yang, Jie Zheng, Shuang Liu, 2011, The Journal of Biological Chemistry.

Synergistic antitumor activity of sorafenib and artesunate in hepatocellular carcinoma cells

Kewei Wang, Xu Yao, Chen-ru Zhao, 2020, Acta Pharmacologica Sinica.

Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats

Yuwei Wu, Y. Gan, Lei Tan, 2010, Molecular pain.

Activation of Neuronal Voltage-Gated Potassium Kv7/KCNQ/M-Current by a Novel Channel Opener SCR2682 for Alleviation of Chronic Pain

Kewei Wang, Jing Wang, Chuanxia Ju, 2021, The Journal of Pharmacology and Experimental Therapeutics.

Inhibition of the Warm Temperature–Activated Ca2+-Permeable Transient Receptor Potential Vanilloid TRPV3 Channel Attenuates Atopic Dermatitis

Kewei Wang, Gongxin Wang, Yaxuan Qu, 2019, Molecular Pharmacology.

Electrophysiological characterization of a small molecule activator on human ether-a-go-go-related gene (hERG) potassium channel.

Kewei Wang, A. Zou, Li-ying Dong, 2019, Journal of pharmacological sciences.

Visualizing TRPA1 in the plasma membrane for rapidly screening optical control agonists via a photochromic ligand based fluorescent probe.

Zhen Qiao, Hongyi Zhang, Ning-ning Wei, 2019, Analytical chemistry.

Capsaicin enhances the antitumor activity of sorafenib in hepatocellular carcinoma cells and mouse xenograft tumors through increased ERK signaling

Hong-xia Yu, Kewei Wang, Chen-ru Zhao, 2017, Acta Pharmacologica Sinica.

Inhibition of Hsp70 Suppresses Neuronal Hyperexcitability and Attenuates Epilepsy by Enhancing A-Type Potassium Current.

Ning-ning Wei, Yiquan Tang, Lizhao Guan, 2019, Cell reports.

Crystal structure of the N-terminal ankyrin repeat domain of TRPV 3 reveals unique conformation of fi nger 3 loop critical for channel function ESEARCH

Kewei Wang, Rongguang Zhang, S. Ye, 2013 .

Crystal structure of the N-terminal ankyrin repeat domain of TRPV3 reveals unique conformation of fi nger 3 loop critical for channel function ESEARCH ARTICLE R

Kewei Wang, Rongguang Zhang, S. Ye, 2013 .

The role of Piezo1 in conventional aqueous humor outflow dynamics

C. R. Ethier, A. Read, D. Overby, 2021, iScience.

A TRPV4 Channel C-terminal Folding Recognition Domain Critical for Trafficking and Function*

Fan Yang, Jie Zheng, Yiquan Tang, 2013, The Journal of Biological Chemistry.

Trafficking and Function Recognition Domain Critical for A TRPV4 Channel C-terminal Folding

Fan Yang, Jie Zheng, Yiquan Tang, 2014 .

Heteromeric Heat-Sensitive TRP Channels Exhibit Distinct Temperature and Chemical Response

M. Zhu, Yuan-yuan Cui, Fan Yang, 2012 .

Auxiliary KChIP4a Suppresses A-type K+ Current through Endoplasmic Reticulum (ER) Retention and Promoting Closed-state Inactivation of Kv4 Channels*

P. Liang, Yiquan Tang, Yanxin Lu, 2013, The Journal of Biological Chemistry.

Inhibition of intracellular proton-sensitive Ca2+-permeable TRPV3 channels protects against ischemic brain injury

Jingliang Zhang, Xiaoling Chen, KeWei Wang, 2022, Acta pharmaceutica Sinica. B.

Identification of two natural coumarin enantiomers for selective inhibition of TRPV2 channels

Yong Jiang, Huijie Liu, Ning-ning Wei, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Anti-pruritic and anti-inflammatory effects of natural verbascoside through selective inhibition of temperature-sensitive Ca2+-permeable TRPV3 channel.

Han Wu, Yaxuan Qu, Xiaoying Sun, 2020, Journal of dermatological science.

Modulation by Clamping: Kv4 and KChIP Interactions

KeWei Wang, 2008, Neurochemical Research.

Inhibition of ANO1/TMEM16A induces apoptosis in human prostate carcinoma cells by activating TNF-α signaling

Jianjun Gao, Jian Gao, Lizhao Guan, 2018, Cell Death & Disease.

Anticonvulsant effect of dipropofol by enhancing native GABA currents in cortical neurons in mice.

Zhuo Huang, Jingliang Zhang, Xiaoling Chen, 2018, Journal of neurophysiology.

Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373).

Kewei Wang, J. Dunlop, E. Tseng, 2006, Assay and drug development technologies.

Molecular determinants for the chemical activation of the warmth-sensitive TRPV3 channel by the natural monoterpenoid carvacrol

Xiaowen Tang, Fang Hu, Canyang Niu, 2022, The Journal of biological chemistry.

The tetramerization domain potentiates Kv4 channel function by suppressing closed-state inactivation.

Fan Yang, Jie Zheng, Yiquan Tang, 2014, Biophysical journal.

Visceral hyperalgesia induced by forebrain-specific suppression of native Kv7/KCNQ/M-current in mice

Xu Cao, Hui Chen, KeWei Wang, 2011, Molecular pain.

Negative modulation of NMDA receptor channel function by DREAM/calsenilin/KChIP3 provides neuroprotection?

Kewei Wang, Yun Wang, KeWei Wang, 2012, Front. Mol. Neurosci..

Photosensitive and Photoswitchable TRPA1 Agonists Optically Control Pain through Channel Desensitization.

Wei Zhu, Zhen Qiao, Jiajie Luo, 2021, Journal of medicinal chemistry.

Capsaicin Changes the Pattern of Brain Rhythms in Sleeping Rats

Wei Lu, Yuhua Tian, Guangxu Du, 2020, Molecules.

Different KChIPs compete for heteromultimeric assembly with pore-forming Kv4 subunits.

Meng Li, Liangyi Chen, Meng Li, 2015, Biophysical journal.

Inhibition of ANO1/TMEM16A induces apoptosis in human prostate carcinoma cells by activating TNF-α signaling

Jianjun Gao, Jian Gao, Lizhao Guan, 2018, Cell Death & Disease.

Design, synthesis and biological activities of piperidine-spirooxadiazole derivatives as α7 nicotinic receptor antagonists.

Siqi Zhao, Lihe Zhang, Hongwei Jin, 2020, European journal of medicinal chemistry.

Comparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine

Kewei Wang, Ying Wang, Jianxun Mi, 2015, PloS one.

Pharmacological Inhibition of the Temperature-Sensitive and Ca2+-Permeable Transient Receptor Potential Vanilloid TRPV3 Channel by Natural Forsythoside B Attenuates Pruritus and Cytotoxicity of Keratinocytes

Q. Ma, Xiaoying Sun, Hang Qi, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Inhibition of Hsp70 suppresses neuronal hyperexcitability and attenuates seizures by enhancing A-type potassium currents

Zhuo Huang, Ning-ning Wei, Yiquan Tang, 2018, bioRxiv.

A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1

V. Yarov-Yarovoy, Fan Yang, Jie Zheng, 2015, Nature Communications.

A Novel Degradation Signal Derived from Distal C-terminal Frameshift Mutations of KCNQ2 Protein Which Cause Neonatal Epilepsy*

Xu Cao, KeWei Wang, Jun Su, 2011, The Journal of Biological Chemistry.

Intracellular Proton-mediated Activation of TRPV3 Channels Accounts for the Exfoliation Effect of α-Hydroxyl Acids on Keratinocytes*

Fan Yang, Jie Zheng, Xu Cao, 2012, The Journal of Biological Chemistry.

Expressional and functional involvement of gap junctions in aqueous humor outflow into the ocular trabecular meshwork of the anterior chamber

Wei Zhu, Xian Yang, X. Qi, 2019, Molecular vision.

Modulation by Clamping: Kv4 and KChIP Interactions

KeWei Wang, 2008, Neurochemical Research.

Development of Automated Patch Clamp Assay for Evaluation of α7 Nicotinic Acetylcholine Receptor Agonists in Automated QPatch-16.

Yuchen Hao, Jing-shu Tang, Kewei Wang, 2015, Assay and drug development technologies.

Pharmacological Characterization of H05, a Novel Serotonin and Noradrenaline Reuptake Inhibitor with Moderate 5-HT2A Antagonist Activity for the Treatment of Depression

Q. Guo, Yani Liu, Xiangqing Xu, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Selective Activation of Nociceptor TRPV1 Channel and Reversal of Inflammatory Pain in Mice by a Novel Coumarin Derivative Muralatin L from Murraya alata*

R. Lai, Yong Jiang, H. Lv, 2015, The Journal of Biological Chemistry.

Zhen Qiao, Hongyi Zhang, Ning-ning Wei, 2019, Chemical communications.