B. Macchia

发表

Synthesis and α-adrenergic and I1-imidazoline activity of 3-phenylpiperidines dimethyl-substituted on the phenyl ring

D. Bylund, G. Giannaccini, A. Lucacchini, 1998 .

Additive NMR shielding parameters for some substituted cyclohexanols

F. Macchia, L. Monti, B. Macchia, 1975 .

The crystal structure of -1--bromophenyl-4--butylcyclohexane

S. Merlino, F. Macchia, G. Berti, 1971 .

An interdisciplinary approach to the design of new structures active at the beta-adrenergic receptor. Aliphatic oxime ether derivatives.

A. Lapucci, M. Breschi, A. Martinelli, 1985, Journal of medicinal chemistry.

Preparation and stereochemical characterization of the diastereoisomeric 1-phenyl-4-t-butylcyclohexene oxides and 1-phenyl-4-t-butylcyclohexane-1,2-diols

F. Macchia, G. Berti, B. Macchia, 1968 .

Relevant differences in the steric course of the cleavage of an aziridine and of the corresponding epoxide

F. Macchia, G. Camici, G. Berti, 1972 .

CONFORMATIONALLY RESTRAINED ANALOGS OF SYMPATHOMIMETIC CATECHOLAMINES - SYNTHESIS AND ADRENERGIC ACTIVITY OF TETRAHYDROBENZOCYCLOHEPTENE DERIVATIVES

A. Lapucci, M. Breschi, A. Martinelli, 1994 .

Stereochemistry of the Additions of Acids to Stilbene and Styrene Oxides1

P. Ferrarini, G. Berti, F. Bottari, 1965 .

Synthesis and β-adrenergic properties of tetrahydronaphthalene analogs of dichloroisoproterenol

C. Martini, M. Breschi, G. Giannaccini, 1993 .

N-n-Propyl-substituted 3-(dimethylphenyl)piperidines display novel discriminative properties between dopamine receptor subtypes: synthesis and receptor binding studies.

G. Demontis, B. Longoni, L. Cervetto, 1998, Journal of medicinal chemistry.

New methods for the preparation of 1-phenyl-trans-cyclohexane-1,2-diol

F. Macchia, G. Berti, F. Bottari, 1965 .

Synthesis and determination of the absolute configurations of the enantiomeric 1,2-epoxy-1-phenylcyclohexanes

F. Macchia, G. Berti, L. Monti, 1968 .

Stereochemistry of some derivatives of phenylcyclohexane

F. Macchia, G. Berti, F. Bottari, 1966 .

Synthesis and α-adrenergic activity of 2- and 6-methyl-substituted (3,4-dihydroxyphenyl)-3-piperidinols

A. Martinelli, E. Orlandini, M. Macchia, 1997 .

Role of the benzylic hydroxyl group of adrenergic catecholamines in eliciting α-adrenergic activity. Synthesis and α1- and α2-adrenergic activity of 3-phenyl-3-piperidinols and their desoxy analogs*

S. Nencetti, E. Orlandini, A. Rossello, 1995 .

Conformationally restrained analogs of sympathomimetic catecholamines. Synthesis, conformational analysis, and adrenergic activity of isochroman derivatives.

C. Martini, A. Lapucci, M. Breschi, 1993, Journal of medicinal chemistry.

Conformational effects on the activity of drugs. 13. A revision of previously proposed models for the activation of alpha- and beta-adrenergic receptors.

C. Martini, A. Lapucci, M. Breschi, 1992, Journal of medicinal chemistry.

Synthesis and evaluation of the pharmacological activity of rigid analogues of sympathomimetic catecholamines derived from bicyclo[2.2.1]heptane.

A. Lapucci, M. Breschi, S. Nencetti, 1989, Journal of medicinal chemistry.

Conformational effects on the activity of drugs. 11. Stereostructural models for the direct activation of the alpha- and beta-adrenergic receptor.

A. Lapucci, M. Breschi, E. Epifani, 1986, Journal of medicinal chemistry.

Conformational effects on the activity of drugs. 10. Synthesis, conformation, and pharmacological properties of 1-(2,5-dimethoxyphenyl)-2-aminoethanols and their morpholine analogues.

A. Lapucci, M. Breschi, E. Epifani, 1983, Journal of medicinal chemistry.

Conformation effects on the activity of drugs. 4. Cyclic analogs of 1-(p-nitrophenyl)-2-isopropylaminoethanol. Synthesis and evaluation of the adrenergic beta-receptor blocking activity of 2-(p-nitrophenyl)-4-isopropylmorpholine.

L. Mazzanti, M. del Tacca, A. Balsamo, 1973, Journal of medicinal chemistry.

Steric inhibition of resonance and regio- and stereoselectivity in the ring opening of 1-arylsubstituted epoxides

A. Balsamo, P. Crotti, F. Macchia, 1973 .

Synthesis, inhibitory activity towards human leukocyte elastase and molecular modelling studies of 1-carbamoyl-4-methyleneaminoxyazetidinones.

A. Martinelli, E. Orlandini, A. Rossello, 2000, European journal of medicinal chemistry.

Conformational studies of small ring derivatives by x-ray crystallography—I

David J. Williams, P. Crotti, F. Macchia, 1975 .

Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole.

A. Lapucci, S. Rapposelli, A. Martinelli, 2002, Journal of medicinal chemistry.

Structure--activity relationship in cinnamamides. 3. Synthesis and anticonvulsant activity evaluation of some derivatives of (E)- and (Z)-m-(trifluoromethyl)cinnamamide.

A. Lapucci, A. Balsamo, P. Crotti, 1981, Journal of Medicinal Chemistry.

Structure-activity relationship in cinnamamides. 2. Synthesis and pharmacological evaluation of some (E)- and (Z)-N-alkyl-alpha, beta-dimethylcinnamamides substituted on the phenyl group.

A. Balsamo, P. Crotti, F. Macchia, 1977, Journal of Medicinal Chemistry.

STRUCTURE-ACTIVITY RELATIONSHIPS IN CINNAMAMIDES PART 1, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME(E)- AND (Z)-N-ALKYL-ALPHA,BETA-DIMETHYLCINNAMAMIDES

A. Pecchia, A. Balsamo, P. Crotti, 1975 .

STRUCTURE-ACTIVITY RELATION IN CINNAMAMIDES. 2. SYNTHESIS AND PHARMACOLOGICAL L EVALUATION OF SOME (E)- AND (Z)-N-ALKYL-α,β-DIMETHYLCINNAMAMIDES SUBSTITUTED ON THE PHENYL GROUP

A. Balsamo, P. Crotti, F. Macchia, 1977 .

STRUCTURE-ACTIVITY RELATIONSHIP IN CINNAMAMIDES. 3. SYNTHESIS AND ANTICONVULSANT ACTIVITY EVALUATION OF SOME DERIVATIVES OF (E)- AND (Z)-M-(TRIFLUOROMETHYL)CINNAMAMIDE

A. Lapucci, A. Balsamo, P. Crotti, 1981 .

The proposal of an unified model for the interpretation of the activity of different classes ofβ-adrenergic agents

A. Balsamo, F. Macchia, B. Macchia, 1975, Experientia.

The crystal structures of dichloroisoproterenol, propranolol and propranolol hydrochloride

H. Ammon, A. Balsamo, F. Macchia, 1977 .

Spirotetrahydronaphthalene analogues of sympathomimetic catecholamines. Synthesis and adrenergic activity of 5,6‐ and 6,7‐dihydroxy‐3,4‐dihydrospiro[naphthalen‐1(2H)‐3′ ‐piperidines]

C. Martini, M. Breschi, A. Martinelli, 2002, The Journal of pharmacy and pharmacology.

Conformationally restrained β-blocking oxime ethers: synthesis and β-adrenergic properties of diastereoisomeric anti and syn 2-(5′-isoxazolidinyl)-ethanolamines

C. Martini, M. Breschi, G. Giannaccini, 1992 .

MOLECULAR ORBITAL STUDIES ON THE MECHANISM OF DRUG-RECEPTOR INTERACTION PART 1, ADRENERGIC DRUGS, CONFORMATION AND REACTIVITY OF ISPROTERENOL AND 1-(P-NITROPHENYL)-2-ISOPROPYLAMINOETHANOL

J. Tomasi, C. Petrongolo, F. Macchia, 1974 .

Stereochemistry of the ring opening of some stilbazole oxides

G. Lippi, G. Berti, F. Bottari, 1968 .

Solvent dependence of the reaction of 1,2-epoxy-1-(p-nitrophenyl)cyclohexane with boron trifluoride–diethyl ether complex

G. Bellucci, F. Macchia, P. Barili, 1974 .

Pinacol-type rearrangements in the phenylcyclohexane series: evidence for differences between the reaction mechanisms of epoxides and of the corresponding diols and halogenohydrins

F. Macchia, G. Berti, L. Monti, 1971 .

Role of the (acyloxy)methyl moiety in eliciting the adrenergic beta-blocking activity of 3-(acyloxy)propanolamines.

A. Lapucci, M. Breschi, A. Martinelli, 1987, Journal of medicinal chemistry.

Molecular orbital studies on the mechanism of drug-receptor interaction. 2. beta-Adrenergic drugs. An approach to explain the role of the aromatic moiety.

A. Martinelli, C. Petrongolo, F. Macchia, 1977, Journal of medicinal chemistry.

Conjugative and inductive effects in the ring opening of 1-aryl substituted oxiranes. Some reactions of 1-(p-methoxyphenyl)- and 1-(m-methoxyphenyl)-1,2-epoxycyclohexanes under acidic conditions

A. Balsamo, P. Crotti, F. Macchia, 1973 .

The balance of steric and conjugative effects in the opening of arylsubstituted oxiranes. Stereochemistry of the ring opening of 1-(1′-naphthyl)-1,2-epoxycyclohexane

P. Crotti, F. Macchia, B. Macchia, 1973 .

Stereochemical characterization of some mono‐ and diaryl substituted ethylene oxides by NMR spectroscopy

G. Lippi, G. Berti, B. Macchia, 1970 .

Nucleophilic step of ring-opening reactions of cyclopropanes with electrophiles. Electronic substituent effects on stereoselectivity of reactions of some 1-arylbicyclo[4.1.0]heptanes with mercuric salts

C. DePuy, P. Crotti, F. Macchia, 1978 .

Critical dependence of the stability of an overcrowded benzylic carbocation on the aromatic ring substituent. Substituent and solvent effects on the ring opening of 1-aryl-substituted epoxides. 1-(p-Methoxyphenyl)-2,2-dimethyl-7-oxabicyclo[4.1.0]heptane

A. Balsamo, P. Crotti, F. Macchia, 1974 .

MO STUDIES ON THE MECHANISM OF DRUG RECEPTOR INTERACTION .4. INTERACTING CONFORMATIONS OF BETA-ADRENERGIC DRUGS

A. Martinelli, F. Macchia, B. Macchia, 1983 .

Effect of substituents on the stereoselectivity of the acid-catalysed hydrolysis of a series of aryloxirans. A new application of the Hammett equation

A. Balsamo, P. Crotti, F. Macchia, 1974 .

Crystal and molecular structure of (3R)-3-(3-methyl-7-phenoxyacetamido-3-cephem-4-yl)-3-hydroxybutanoic acid

A. Balsamo, F. Macchia, P. Domiano, 1987 .

Crystal and molecular structure of 4-acetyl-3-methyl-7β-phenoxyacetamido-Δ3-cephem

M. Nardelli, A. Balsamo, F. Macchia, 1978 .

SYNTHESIS OF SOME 1-ARYL-1,2-EPOXYCYCLOHEXANES AND THEIR STEREOSELECTIVE CONVERSION INTO THE CORRESPONDING DIASTEREOISOMERIC 1-ARYLCYCLOHEXANE-1,2-DIOLS

A. Balsamo, P. Crotti, F. Macchia, 1976 .

(E)-[2-(4-Methylsulphonylphenyl)-1-cyclopentenyl-1-methyliden](arylmethyloxy)amines. Methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: synthesis and biological properties.

Elisabetta Orlandini, Isabella Coletta, F. Mancini, 2002, European journal of medicinal chemistry.

Dimethyl sulphoxide as a solvent for the hydrolytic cleavage of epoxides. Synthesis of the four diastereoisomeric 4-tert-butylcyclohexane-1,2-diols.

F. Macchia, G. Berti, B. Macchia, 1965, Tetrahedron letters.

The direction of ring opening of trans-α-methylstilbene oxide by organic acids

G. Berti, F. Bottari, B. Macchia, 1964 .

New N-n-propyl-substituted 3-aryl- and 3-cyclohexylpiperidines as partial agonists at the D4 dopamine receptor.

G. Demontis, B. Longoni, L. Cervetto, 2003, Journal of Medicinal Chemistry.

Stereochemistry and mechanism of pinacol-type rearrangements in the 1-phenyl-4-t-butylcyclohexane series

F. Macchia, P. Barili, G. Berti, 1970 .

Synthesis and dopaminergic properties of the two enantiomers of 3-(3,4-dimethylphenyl)-1-propylpiperidine, a potent and selective dopamine D4 receptor ligand.

G. Demontis, B. Longoni, L. Cervetto, 2001, Bioorganic & medicinal chemistry letters.

Is the conformation of the thiazolidine ring of penicillins of any importance for their antibacterial activity

M. Nardelli, A. Balsamo, F. Macchia, 1980 .

Crystal and molecular structure of tetrabutylammonium (3lS, 4S)-3-phenylacetamido-4-methyl-2-oxoazetidine-1-sulfonate

A. Rossello, A. Balsamo, F. Macchia, 1991 .

Synthesis and antimicrobial properties of new cepham and penam derivatives with the carboxylic group in the wrong β-configuration

S. Nencetti, E. Orlandini, A. Rossello, 1989 .

Synthesis and pharmacological activity of 1-phenyl-2-oxa-5-azabicyclo[4.4.0]decane derivatives

A. Lapucci, A. Balsamo, F. Macchia, 1984 .

Configuration study of some 9-substituted 3-oxabicyclo[3.3.1]nonanes by nuclear magnetic resonance

G. Lippi, P. Bucci, B. Macchia, 1970 .

Crystal and molecular structure of p-methoxybenzyl 2α-methyl-2β-[(R)-acetoxy(methoxy)methyl]-6β-phenoxyacetamidopenam-3α-carboxylate

M. Nardelli, A. Balsamo, F. Macchia, 1979 .

3-(4-iodomethyl-2-oxo-1-azetidinyl)propynoic acidt-butyl ester: a new β-lactam derivative, synthesis of an ynamide by reaction of 4-iodomethylazetidin-2-one with the t-butyl ester of propiolic acid in the presence of copper(i)

A. Rossello, A. Balsamo, F. Macchia, 1985 .

The dimeric nature of the supposed 2-P-anisylnorbornene 2,3-exo-oxide

C. Anselmi, F. Macchia, P. Barili, 1970 .

Molecular design, synthesis, and antiinflammatory activity of a series of beta-aminoxypropionic acids.

A. Lapucci, A. Martinelli, S. Nencetti, 1990, Journal of medicinal chemistry.