Sushant Malhotra

发表

Substituted 3-imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino-[6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as highly selective and potent inhibitors of glycogen synthase kinase-3.

R. Campbell, P. Iversen, M. Clay, 2004, Journal of medicinal chemistry.

The development of potent and selective bisarylmaleimide GSK3 inhibitors.

R. Campbell, B. Anderson, T. Engler, 2005, Bioorganic & medicinal chemistry letters.

Dinuclear zinc-catalyzed asymmetric desymmetrization of acyclic 2-substituted-1,3-propanediols: a powerful entry into chiral building blocks.

B. Trost, T. Mino, N. Rajapaksa, 2008, Chemistry.

CLAMPs allow single cell tracking of KRASG12C inhibition and endow druggability to KRAS mutants

Marie Evangelista, H. Koeppen, Y. Franke, 2021 .

Development of an Efficient Manufacturing Process for Reversible Bruton’s Tyrosine Kinase Inhibitor GDC-0853

F. Gosselin, D. Linder, Jessica L. Defreese, 2018, Organic Process Research & Development.

Magnesium-catalyzed asymmetric direct aldol addition of ethyl diazoacetate to aromatic, aliphatic, and alpha,beta-unsaturated aldehydes.

B. Trost, Sushant Malhotra, Benjamin A. Fried, 2009, Journal of the American Chemical Society.

Development of the enantioselective addition of ethyl diazoacetate to aldehydes: asymmetric synthesis of 1,2-diols.

B. Trost, P. Koschker, Sushant Malhotra, 2012, Journal of the American Chemical Society.

Manufacture of the PI3K β-Sparing Inhibitor Taselisib. Part 2: Development of a Highly Efficient and Regioselective Late-Stage Process

A. Schuster, F. Gosselin, G. Ohlenbusch, 2019, Organic Process Research & Development.

Total synthesis of (-)-18-epi-peloruside A: an alkyne linchpin strategy.

B. Trost, D. Michaelis, Sushant Malhotra, 2013, Organic letters.

Exploring the unique reactivity of diazoesters: an efficient approach to chiral β-amino acids.

B. Trost, Sushant Malhotra, Pascal Ellerbrock, 2013, Organic letters.

Asymmetric synthesis of diamine derivatives via sequential palladium and rhodium catalysis.

B. Trost, J. Du Bois, David E Olson, 2009, Journal of the American Chemical Society.

Synthetic approaches to indolo[6,7-a]pyrrolo[3,4-c]carbazoles: potent cyclin D1/CDK4 inhibitors.

S. W. Pedersen, M. Martinelli, J. M. Pawlak, 2004, The Journal of organic chemistry.

Chemoselective sp2-sp3 cross-couplings: iron-catalyzed alkyl transfer to dihaloaromatics.

Kevin A Ford, Kevin A. Ford, Sushant Malhotra, 2013, Organic letters.

Palladium-catalyzed α-arylation of sultams with aryl and heteroaryl iodides.

B. Fauber, Olivier René, Sushant Malhotra, 2014, Organic letters.

Exercising regiocontrol in palladium-catalyzed asymmetric prenylations and geranylation: unifying strategy toward flustramines A and B.

B. Trost, W. Chan, Sushant Malhotra, 2011, Journal of the American Chemical Society.

Development of the Regiodivergent Asymmetric Prenylation of 3-Substituted Oxindoles.

B. Trost, W. Chan, Sushant Malhotra, 2017, Chemistry.

Magnesium-Catalyzed Asymmetric Direct Aldol Addition of Ethyl Diazoacetate to Aromatic, Aliphatic, and α,β-Unsaturated Aldehydes.

B. Trost, Sushant Malhotra, Benjamin A. Fried, 2009 .

Asymmetric stereodivergent strategy towards aminocyclitols.

B. Trost, Sushant Malhotra, 2014, Chemistry.

Chemoselective chromium(II)-catalyzed cross-coupling reactions of dichlorinated heteroaromatics with functionalized aryl grignard reagents.

P. Knochel, A. Steib, O. Kuzmina, 2015, Chemistry.

Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles.

S. A. Watkins, R. Campbell, J. Dempsey, 2003, Bioorganic & medicinal chemistry letters.

Process Development Overcomes a Challenging Pd-Catalyzed C–N Coupling for the Synthesis of RORc Inhibitor GDC-0022

F. Gosselin, David B. Lao, Paroma Chakravarty, 2020 .

Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).

Hoai An Le Thi, E. Gancia, BinQing Wei, 2021, ACS medicinal chemistry letters.

An improved method for direct conversion of heteroaryl-aldehydes to heteroaryl-acetonitriles

T. Engler, J. Clayton, C. Diefenbacher, 2003 .

Chemoselective sp2-sp3 cross-couplings: iron-catalyzed alkyl transfer to dihaloaromatics.

Kevin A. Ford, S. Koenig, A. Deese, 2013, Organic letters.

Development of the enantioselective addition of ethyl diazoacetate to aldehydes: asymmetric synthesis of 1,2-diols.

B. Trost, P. Koschker, Sushant Malhotra, 2012, Journal of the American Chemical Society.

Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).

Hoai An Le Thi, E. Gancia, Weiru Wang, 2021, ACS medicinal chemistry letters.