Wei Li

发表

Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration

M. Ultsch, E. Green, A. Rohou, 2022, Nature Communications.

Pro-urokinase-type Plasminogen Activator Is a Substrate for Hepsin*

R. Vij, D. Kirchhofer, C. Eigenbrot, 2006, Journal of Biological Chemistry.

Identification of Hepatocyte Growth Factor Activator Inhibitor-1B as a Potential Physiological Inhibitor of Prostasin*

Thomas D. Wu, D. Kirchhofer, B. Fan, 2005, Journal of Biological Chemistry.

The Serine Protease Marapsin Is Expressed in Stratified Squamous Epithelia and Is Up-regulated in the Hyperproliferative Epidermis of Psoriasis and Regenerating Wounds*

Thomas D. Wu, S. Sa, D. Danilenko, 2009, Journal of Biological Chemistry.

Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists

A. Peterson, M. Ultsch, P. Di Lello, 2017, Nature Structural &Molecular Biology.

Furin-cleaved Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Is Active and Modulates Low Density Lipoprotein Receptor and Serum Cholesterol Levels

A. Peterson, D. Arnott, D. Kirchhofer, 2012, The Journal of Biological Chemistry.

Calcium-independent inhibition of PCSK9 by affinity-improved variants of the LDL receptor EGF(A) domain.

A. Peterson, N. Skelton, Yingnan Zhang, 2012, Journal of molecular biology.

Deviation of Trypsin Activity Using Peptide Conformational Imprints

R. Kankala, Chia-Hung Lee, D. Tai, 2021, Nanomaterials.

Design of organo-peptides as bipartite PCSK9 antagonists.

M. Ultsch, N. Skelton, Yingnan Zhang, 2020, ACS chemical biology.

Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy

Shadi Toghi Eshghi, L. Honigberg, M. van Lookeren Campagne, 2020, Proceedings of the National Academy of Sciences.

Experimental Therapeutics , Molecular Targets , and Chemical Biology Pegylated Kunitz Domain Inhibitor Suppresses Hepsin-Mediated Invasive Tumor Growth and Metastasis

M. J. C. Ludlam, H. Koeppen, D. Kirchhofer, 2009 .

Experimental Therapeutics, Molecular Targets, and Chemical Biology Pegylated Kunitz Domain Inhibitor Suppresses Hepsin-mediated Invasive Tumor Growth and Metastasis

H. Koeppen, D. Kirchhofer, S. Bunting, 2022 .

Identification of a Small Peptide That Inhibits PCSK9 Protein Binding to the Low Density Lipoprotein Receptor

Wei Li, Jeffrey Tom, Nicholas J Skelton, 2013, The Journal of Biological Chemistry.

Cystine-knot peptide inhibitors of HTRA1 bind to a cryptic pocket within the active site region

M. Ultsch, R. Hannoush, Wei Li, 2024, Nature communications.

Identification of a Helical Segment within the Intrinsically Disordered Region of the PCSK9 Prodomain.

M. Ultsch, C. Eigenbrot, Y. Franke, 2019, Journal of molecular biology.

Hepsin overexpression promotes tumor growth in an orthotopic prostate cancer model

D. Kirchhofer, M. J. Cole, S. Bunting, 2007 .