Allyn T. Londregan

发表

Structure and inhibitor binding characterization of oncogenic MLLT1 mutants

S. Knapp, A. Chaikuad, D. Owen, 2021, bioRxiv.

Tetrahydro-4-quinolinamines identified as novel P2Y(1) receptor antagonists.

Dwight M. Morrow, N. Aiyar, P. Li, 2008, Bioorganic & medicinal chemistry letters.

Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.

Jeffrey R. Chabot, P. Loria, C. Halldin, 2017, Angewandte Chemie.

Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.

K. Fennell, O. Fedorov, P. Loria, 2022, Journal of medicinal chemistry.

General and mild preparation of 2-aminopyridines.

Liuqing Wei, S. Jennings, Allyn T. Londregan, 2010, Organic letters.

A new and useful method for the macrocyclization of linear peptides.

K. Farley, C. Limberakis, Chris Limberakis, 2012, Organic letters.

Mild addition of nucleophiles to pyridine-N-oxides.

Liuqing Wei, S. Jennings, Allyn T. Londregan, 2011, Organic letters.

Synthesis of Pyridazine-Based α-Helix Mimetics.

D. W. Piotrowski, D. Piotrowski, Liuqing Wei, 2016, ACS combinatorial science.

Preparation of Heteroaryl Ethers from Azine N-Oxides and Alcohols.

Y. Lian, S. Coffey, Qifang Li, 2016, Organic letters.

Expedient Synthesis of N1-Substituted Triazole Peptidomimetics.

S. Coffey, G. Aspnes, Allyn T. Londregan, 2015, ACS combinatorial science.

Expedient synthesis of α-heteroaryl piperidines using a Pd-catalyzed Suzuki cross-coupling-reduction sequence.

Wenhua Jiao, Kevin D. Hesp, D. Fernando, 2014, Organic letters.

Construction of 1-Heteroaryl-3-azabicyclo[3.1.0]hexanes by sp3-sp2 Suzuki-Miyaura and Chan-Evans-Lam Coupling Reactions of Tertiary Trifluoroborates.

Y. Lian, Michael R Harris, Qifang Li, 2017, Organic letters.

Synthesis and biological evaluation of manzamine analogues.

J. Winkler, M. Hamann, Justin R. Ragains, 2006, Organic letters.

Antimalarial activity of a new family of analogues of manzamine A.

J. Winkler, M. Hamann, Allyn T. Londregan, 2006, Organic letters.

Expedient synthesis of α-(2-azaheteroaryl) acetates via the addition of silyl ketene acetals to azine-N-oxides.

Edward L. Conn, Kevin D. Hesp, Kristen Burford, 2014, Organic letters.

An improved amide coupling procedure for the synthesis of N-(pyridin-2-yl)amides

J. Warmus, Xiaojing Yang, G. Storer, 2009 .

Discovery of a Novel Small-Molecule Modulator of C-X-C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis.

David A. Price, A. Kalgutkar, K. Beaumont, 2018, Journal of medicinal chemistry.

Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment.

M. Ammirati, A. Carlo, A. Mathiowetz, 2015, ACS medicinal chemistry letters.

Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.

R. Kurumbail, M. Harris, Hong Wang, 2014, Structure.

Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents.

Jeffrey R. Chabot, J. Cate, J. Warmus, 2018, Journal of medicinal chemistry.

Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

J. Doudna, J. Cate, P. Loria, 2017, PLoS biology.

Discovery and Evaluation of Non-Basic Small Molecule Modulators of the Atypical Chemokine Receptor CXCR7.

M. Boehm, C. Limberakis, Janice A. Brown, 2021, Bioorganic & medicinal chemistry letters.

Expedient synthesis of gem-dialkylbenzyl heterocycles through olefinic hydroarylation

Y. Lian, Kristen Burford, Allyn T. Londregan, 2015 .

A compound that directly and selectively stalls PCSK9 translation

J. Doudna, J. Cate, P. Loria, 2016, bioRxiv.

Title : A compound that directly and selectively stalls PCSK 9 translation 1 2

J. Cate, P. Loria, S. Liras, 2016 .

Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate.

P. Loria, D. Hepworth, S. Bhattacharya, 2014, ACS medicinal chemistry letters.

Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries.

J. Warmus, M. Boehm, K. Futatsugi, 2013, Bioorganic & medicinal chemistry letters.

Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists.

A. Kalgutkar, J. Warmus, D. Hepworth, 2013, ACS medicinal chemistry letters.

Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.

P. Loria, J. Bauman, David A. Price, 2022, Journal of medicinal chemistry.

Preparation of Azinones from (Cyclopropylmethoxy)azine Ethers.

S. Berritt, John M. Curto, Colin R. Rose, 2023, Journal of Organic Chemistry.

Synthetic modification of manzamine A via Grubbs metathesis. Novel structures with enhanced antibacterial and antiprotozoal properties.

J. Winkler, M. Hamann, Allyn T. Londregan, 2007, Organic letters.

Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3.

C. C. Jorgensen, Hao Sun, M. Boehm, 2015, Journal of medicinal chemistry.

Sequential Xanthalation and O-Trifluoromethylation of Phenols: A Procedure for the Synthesis of Aryl-trifluoromethyl Ethers.

J. Hartwig, Y. Lian, Makoto Yoritate, 2019, The Journal of organic chemistry.

Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.

R. Kurumbail, M. Harris, Hong Wang, 2014, Structure.

Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.

C. Limberakis, B. Raux, D. Owen, 2023, Bioorganic & medicinal chemistry letters.

The enantioselective synthesis of (R)- and (S)-3-amino-3,4-dihydro-1H-[1,8]naphthyridin-2-one

J. Warmus, David J. Bernhardson, Xiaojing Yang, 2010 .

Spiroazetidine–piperidine bromoindane as a key modular template to access a variety of compounds via C–C and C–N bond-forming reactions

S. Bhattacharya, K. McClure, Wenhua Jiao, 2012 .