Pablo D. Garcia

发表

Discovery of chiral dihydropyridopyrimidinones as potent, selective and orally bioavailable inhibitors of AKT.

B. Condon, Yong Wang, S. Geeganage, 2018, Bioorganic & medicinal chemistry letters.

Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.

Yu Ding, Michelle Mathur, Jiong Lan, 2013, ACS medicinal chemistry letters.

Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers

Audrey Kauffmann, Jianjun Yu, Yumin Dai, 2014, Clinical Cancer Research.

Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation.

Jianjun Yu, Yumin Dai, Janet Sim, 2013, Blood.

Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies.

Yumin Dai, Yanchen Zhang, Mika K Lindvall, 2015, Journal of medicinal chemistry.

Synthesis and Structure-Activity Relationship of Tetra-Substituted Cyclohexyl Diol Inhibitors of Proviral Insertion of Moloney Virus (PIM) Kinases.

M. Lindvall, Yu Ding, Jiong Lan, 2020, Journal of medicinal chemistry.

Discovery of novel 3,5-disubstituted indole derivatives as potent inhibitors of Pim-1, Pim-2, and Pim-3 protein kinases.

Mika Lindvall, M. Lindvall, Yu Ding, 2011, Bioorganic & medicinal chemistry letters.

Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold.

M. Lindvall, Jiong Lan, Gordana Atallah, 2016, Bioorganic & medicinal chemistry letters.

The Combination Of JAK Inhibitor, Ruxolitinib, and PIM Inhibitor, LGH447, In Preclinical Models Of Myeloproliferative Neoplasia

G. Caponigro, Z. Cao, M. Pinzon-Ortiz, 2013 .

Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers

M. Lindvall, A. Kauffmann, C. Fanton, 2014, Clinical Cancer Research.