Jun-Ye Hong

PolyQ-expanded proteins impair cellular proteostasis of ataxin-3 through sequestering the co-chaperone HSJ1 into aggregates

H. Yue, Hong-Yu Hu, Lei-Lei Jiang, 2021, Scientific Reports.

The N-terminal dimerization is required for TDP-43 splicing activity

Hong-Yu Hu, Jian-Hua He, Jun-Ye Hong, 2017, Scientific Reports.

HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19

H. Yue, Hong-Yu Hu, Wen-tian He, 2017, Scientific Reports.

PolyQ‐expanded huntingtin and ataxin‐3 sequester ubiquitin adaptors hHR23B and UBQLN2 into aggregates via conjugated ubiquitin

H. Yue, Hong-Yu Hu, Wen-tian He, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Structural and dynamic studies reveal that the Ala-rich region of ataxin-7 initiates α-helix formation of the polyQ tract but suppresses its aggregation

H. Yue, Hong-Yu Hu, Hui Yang, 2019, Scientific Reports.

HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19

H. Yue, Hong-Yu Hu, Wen-tian He, 2017, Scientific Reports.

Domain interactions reveal auto-inhibition of the deubiquitinating enzyme USP19 and its activation by HSP90 in modulation of huntingtin aggregation.

Hong-Yu Hu, Wen-tian He, Jun-Ye Hong, 2020, The Biochemical journal.

Coaggregation of polyglutamine (polyQ) proteins is mediated by polyQ-tract interactions and impairs cellular proteostasis

H. Yue, Hong-Yu Hu, Jun-Ye Hong, 2023, Acta biochimica et biophysica Sinica.