L. Lambert

发表

Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).

S. Knapp, N. Cosford, L. J. Lambert, 2019, The Biochemical journal.

Perturbation of the c-Myc-Max protein-protein interaction via synthetic α-helix mimetics.

E. Prochownik, Huabo Wang, N. Cosford, 2015, Journal of medicinal chemistry.

Synthesis, bioactivity, and DNA-cleaving ability of desferrioxamine B-nalidixic acid and anthraquinone carboxylic acid conjugates

L. J. Lambert, P. Huber, M. Ghosh, 1995 .

Molecular analysis of activator engagement with RNA polymerase.

M. H. Werner, B. Demeler, V. Schirf, 2003, Methods in enzymology.

T4 AsiA blocks DNA recognition by remodeling σ70 region 4

M. H. Werner, L. J. Lambert, B. Demeler, 2004 .

Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP)

T. Chung, N. Cosford, A. Bobkov, 2021, International journal of molecular sciences.

Uniform 13C/15N-labeling of DNA by tandem repeat amplification.

M. H. Werner, L. J. Lambert, T. Nagata, 2001, Methods in enzymology.

Flipping a genetic switch by subunit exchange

M. Cadene, M. H. Werner, B Demeler, 2001, The EMBO journal.

Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2)

S. Knapp, N. Cosford, L. J. Lambert, 2019, bioRxiv.

Discovery of novel furanylbenzamide inhibitors that target oncogenic tyrosine phosphatase SHP2 in leukemia cells

K. Vuori, N. Cosford, E. Pasquale, 2021, The Journal of biological chemistry.

Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors.

D. Sheffler, N. Cosford, L. J. Lambert, 2020, Journal of visualized experiments : JoVE.

A cellular target engagement assay for the characterization of SHP2 (PTPN11) phosphatase inhibitors

D. Sheffler, E. Sergienko, N. Cosford, 2020, The Journal of Biological Chemistry.

Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia.

S. Knapp, D. Sheffler, N. Cosford, 2021, Journal of medicinal chemistry.

Autophagy in Cancer: Regulation by Small Molecules.

R. Shaw, N. Cosford, L. J. Lambert, 2018, Trends in pharmacological sciences.

Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer.

S. Knapp, D. Sheffler, R. Shaw, 2020, Journal of medicinal chemistry.

Competitive Interactions of Collagen and a Jararhagin-derived Disintegrin Peptide with the Integrin α2-I Domain*

Jeffrey W. Smith, A. Bobkov, L. J. Lambert, 2008, Journal of Biological Chemistry.

Tetrahydrofuranyl and tetrahydropyranyl protection of amino acid side-chains enables synthesis of a hydroxamate-containing aminoacylated tRNA.

L. J. Lambert, P. Huber, Marvin J Miller, 2015, Organic & biomolecular chemistry.

Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface.

J. Decaprio, B. Schulman, M. Hammel, 2012, Molecular cell.