Mariko Sato

Synthesis and biological evaluation of the natural product komaroviquinone and related compounds aiming at a potential therapeutic lead compound for high-risk multiple myeloma.

F. Kiuchi, D. Ichikawa, M. Matsushita, 2017, Bioorganic & medicinal chemistry letters.

A novel derivative (GTN024) from a natural product, komaroviquinone, induced the apoptosis of high-risk myeloma cells via reactive oxygen production and ER stress.

Taketo Yamada, F. Kiuchi, S. Okamoto, 2018, Biochemical and biophysical research communications.

GTN057, a komaroviquinone derivative, induced myeloma cells' death in vivo and inhibited c‐MET tyrosine kinase

H. Sugiyama, F. Kiuchi, D. Ichikawa, 2023, Cancer medicine.