Huixiao Hong

Chaoyang Zhang, Yan Li, Huixiao Hong, 2018, Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews.

Bioinformatics approaches for cross-species liver cancer analysis based on microarray gene expression profiling

Weida Tong, Huixiao Hong, Leming Shi, 2005, BMC Bioinformatics.

Comparative toxicogenomics of three insensitive munitions constituents 2,4-dinitroanisole, nitroguanidine and nitrotriazolone in the soil nematode Caenorhabditis elegans

Kurt A. Gust, Huixiao Hong, Xin Guan, 2018, BMC Systems Biology.

Competitive molecular docking approach for predicting estrogen receptor subtype α agonists and antagonists

Weida Tong, Huixiao Hong, Roger Perkins, 2014, BMC Bioinformatics.

Mold2, Molecular Descriptors from 2D Structures for Chemoinformatics and Toxicoinformatics

Weida Tong, Huixiao Hong, Leming Shi, 2008, J. Chem. Inf. Model..

Estimating relative noise to signal in DNA microarray data

Jie Liu, Weida Tong, Huixiao Hong, 2013, Int. J. Bioinform. Res. Appl..

Two new ArrayTrack libraries for personalized biomedical research

Weida Tong, Huixiao Hong, Hong Fang, 2010, BMC Bioinformatics.

sNebula, a network-based algorithm to predict binding between human leukocyte antigens and peptides

Hao Ye, Huixiao Hong, Heng Luo, 2016, Scientific Reports.

ESSESA: An Expert System for Structure Elucidation from Spectra. 5. Substructure Constraints from Analysis of First-Order 1H-NMR Spectra

Huixiao Hong, Xin Xinquan, 1994, J. Chem. Inf. Comput. Sci..

Development of a Nicotinic Acetylcholine Receptor nAChR α7 Binding Activity Prediction Model

Huixiao Hong, Wenjing Guo, Sugunadevi Sakkiah, 2020, J. Chem. Inf. Model..

Alignment of Short Reads: A Crucial Step for Application of Next-Generation Sequencing Data in Precision Medicine

Hao Ye, Weida Tong, Huixiao Hong, 2015, Pharmaceutics.

Development of public toxicogenomics software for microarray data management and analysis.

Weida Tong, Qian Xie, Huixiao Hong, 2004, Mutation research.

Direct comparison of performance of single nucleotide variant calling in human genome with alignment-based and assembly-based approaches

Weida Tong, Huixiao Hong, Leihong Wu, 2017, Scientific Reports.

Correction to: Similarities and differences between variants called with human reference genome HG19 or HG38

Chaoyang Zhang, Weida Tong, Huixiao Hong, 2019, BMC Bioinformatics.

Spec2D: A Structure Elucidation System Based on 1H NMR and H-H COSY Spectra in Organic Chemistry

Huixiao Hong, Hideyuki Masui, 2006, J. Chem. Inf. Model..

Whole genome sequencing of 35 individuals provides insights into the genetic architecture of Korean population

Weida Tong, Huixiao Hong, Roger Perkins, 2014, BMC Bioinformatics.

The EDKB: an established knowledge base for endocrine disrupting chemicals

Lei Xu, Weida Tong, Huixiao Hong, 2010, BMC Bioinformatics.

Very Important Pool (VIP) genes – an application for microarray-based molecular signatures

Weida Tong, Huixiao Hong, Leming Shi, 2008, BMC Bioinformatics.

Molecular Docking for Identification of Potential Targets for Drug Repurposing.

Heng Luo, Huixiao Hong, William Mattes, 2016, Current topics in medicinal chemistry.

ESSESA: An expert system for structure elucidation from spectra. 3. LNSCS for chemical knowledge representation

Huixiao Hong, Xin Xinquan, 1992, J. Chem. Inf. Comput. Sci..

In Silico Pharmacoepidemiologic Evaluation of Drug-Induced Cardiovascular Complications Using Combined Classifiers

Qi Wang, Chuipu Cai, Pengfei Guo, 2018, J. Chem. Inf. Model..

Chaoyang Zhang, Weida Tong, Huixiao Hong, 2019, BMC Bioinformatics.

Discriminant models on mitochondrial toxicity improved by consensus modeling and resolving imbalance in training.

Huixiao Hong, Jingwen Chen, Weihao Tang, 2020, Chemosphere.

Deep learning architectures for multi-label classification of intelligent health risk prediction

Chaoyang Zhang, Heng Weng, Runzhi Li, 2017, BMC Bioinformatics.

Microarray scanner calibration curves: characteristics and implications

Tao Han, James J. Chen, Weida Tong, 2005, BMC Bioinformatics.

Development of Nicotinic Acetylcholine Receptor nAChR α7 Binding Activity Prediction Model: Coupling Machine Learning with Competitive Molecular Docking

Huixiao Hong, Carmine Leggett, Suguna Sakkiah, 2017, BCB.

Deep learning for predicting toxicity of chemicals: a mini review

Huixiao Hong, Zhongyu Wang, Jingwen Chen, 2018, Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews.

Individualized network-based drug repositioning infrastructure for precision oncology in the panomics era

Sheng-Yong Yang, Feixiong Cheng, Huixiao Hong, 2016, Briefings Bioinform..

A novel procedure on next generation sequencing data analysis using text mining algorithm

Yuping Wang, Weizhong Zhao, James J. Chen, 2016, BMC Bioinformatics.

Quality control and quality assessment of data from surface-enhanced laser desorption/ionization (SELDI) time-of flight (TOF) mass spectrometry (MS)

Weida Tong, Huixiao Hong, Leming Shi, 2005, BMC Bioinformatics.

A review on machine learning methods for in silico toxicity prediction

Chaoyang Zhang, Huixiao Hong, Minjun Chen, 2018, Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews.

From decision tree to heterogeneous decision forest : A novel chemometrics approach for structure-activity relationship modeling

Weida Tong, Huixiao Hong, Hong Fang, 2005 .

Assessing batch effects of genotype calling algorithm BRLMM for the Affymetrix GeneChip Human Mapping 500 K array set using 270 HapMap samples

Tao Han, James J. Chen, Weida Tong, 2008, BMC Bioinformatics.

A Review of Feature Reduction Methods for QSAR-Based Toxicity Prediction

Chaoyang Zhang, Huixiao Hong, Minjun Chen, 2019, Challenges and Advances in Computational Chemistry and Physics.

Accurate Prediction and Recognition of Subfamilies of G Protein-Coupled Receptors from Amino Acid Sequences

Weida Tong, Huixiao Hong, Qilong Hong, 2009, BIOCOMP.

Cross-platform comparability of microarray technology: Intra-platform consistency and appropriate data analysis procedures are essential

Tao Han, James J. Chen, Weida Tong, 2005, BMC Bioinformatics.

Mode-of-Action-Guided, Molecular Modeling-Based Toxicity Prediction: A Novel Approach for In Silico Predictive Toxicology

Chaoyang Zhang, Yan Li, Huixiao Hong, 2019, Challenges and Advances in Computational Chemistry and Physics.

Consensus analysis of multiple classifiers using non-repetitive variables: Diagnostic application to microarray gene expression data

Weida Tong, Huixiao Hong, Roger Perkins, 2007, Comput. Biol. Chem..

Evaluation of gene expression data generated from expired Affymetrix GeneChip® microarrays using MAQC reference RNA samples

Charles Wang, Ying Huang, Quan Shi, 2010, BMC Bioinformatics.

QSAR Models at the US FDA/NCTR.

Weida Tong, Huixiao Hong, Minjun Chen, 2016, Methods in molecular biology.

Homology modeling, molecular docking, and molecular dynamics simulations elucidated α-fetoprotein binding modes

Weida Tong, Huixiao Hong, Hong Fang, 2013, BMC Bioinformatics.

Predictive Models to Identify Small Molecule Activators and Inhibitors of Opioid Receptors

Ruili Huang, Anton Simeonov, Menghang Xia, 2021, J. Chem. Inf. Model..

Text Fingerprinting and Topic Mining in the Prescription Opioid Use Literature

Weizhong Zhao, Weida Tong, Huixiao Hong, 2021 .

Versatility or Promiscuity: The Estrogen Receptors, Control of Ligand Selectivity and an Update on Subtype Selective Ligands

Weida Tong, Huixiao Hong, Roger Perkins, 2014, International journal of environmental research and public health.

ehp CERAPP : Collaborative Estrogen Receptor Activity Prediction Project

Ruili Huang, Igor V. Tetko, Eva Bay Wedebye, 2016 .

Modeling Chemical Interaction Profiles: I. Spectral Data-Activity Relationship and Structure-Activity Relationship Models for Inhibitors and Non-inhibitors of Cytochrome P450 CYP3A4 and CYP2D6 Isozymes

Bruce A. Pearce, Laura K. Schnackenberg, Dan A. Buzatu, 2012, Molecules.

CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity

Ruili Huang, Scott Boyer, Xin Hu, 2020, Environmental health perspectives.

Emerging efforts for discovering new biomarkers of liver disease and hepatotoxicity.

Weida Tong, Huixiao Hong, W. Tong, 2014, Biomarkers in medicine.

Development of Quantitative Structure-Activity Relationships ( QSARs ) and Their Use for Priority Setting in the Testing Strategy of Endocrine Disruptors

Weida Tong, Qian Xie, Huixiao Hong, 2002 .

Quantitative structure-activity relationship models for predicting drug-induced liver injury based on FDA-approved drug labeling annotation and using a large collection of drugs.

Weida Tong, Huixiao Hong, Hong Fang, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Evaluation of external RNA controls for the assessment of microarray performance

Weida Tong, Huixiao Hong, Leming Shi, 2006, Nature Biotechnology.

Challenges, Solutions, and Quality Metrics of Personal Genome Assembly in Advancing Precision Medicine

Huixiao Hong, Leihong Wu, Baitang Ning, 2016, Pharmaceutics.

Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact

Jiri Aubrecht, Weida Tong, Huixiao Hong, 2010, Nature Reviews Drug Discovery.

Genome-Wide Association Studies of Type 2 Diabetes: Current Status, Open Challenges, and Future Perspectives

Weida Tong, Huixiao Hong, Donna L. Mendrick, 2011 .

Toxicogenomics and Cancer Susceptibility: Advances with Next-Generation Sequencing

Huixiao Hong, Leming Shi, Zhenqiang Su, 2014, Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews.

Machine Learning Methods for Predicting HLA–Peptide Binding Activity

Weida Tong, Huixiao Hong, Leming Shi, 2015, Bioinformatics and biology insights.

Next generation sequencing for profiling expression of miRNAs: technical progress and applications in drug development.

Weida Tong, Huixiao Hong, Steven F Jennings, 2011, Journal of biomedical science and engineering.

SNPTrackTM : an integrated bioinformatics system for genetic association studies

Weida Tong, Huixiao Hong, Hong Fang, 2012, Human Genomics.

Biomarker-based drug safety assessment in the age of systems pharmacology: from foundational to regulatory science.

Feixiong Cheng, Huixiao Hong, Yun Tang, 2015, Biomarkers in medicine.

Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor.

Weida Tong, Qian Xie, Huixiao Hong, 2003, Chemical research in toxicology.

Biomarkers for drug-induced liver injury

Weida Tong, Huixiao Hong, Qiang Shi, 2010, Expert review of gastroenterology & hepatology.

Evaluating variations of genotype calling: a potential source of spurious associations in genome-wide association studies

Weida Tong, Huixiao Hong, Leming Shi, 2010, Journal of Genetics.

Understanding and predicting binding between human leukocyte antigens (HLAs) and peptides by network analysis

Weida Tong, Huixiao Hong, Leming Shi, 2015, BMC Bioinformatics.

Potential Sources of Spurious Associations and Batch Effects in Genome‐Wide Association Studies

Weida Tong, Huixiao Hong, Leming Shi, 2009 .

Pitfall of genome-wide association studies: Sources of inconsistency in genotypes and their effects

Weida Tong, Huixiao Hong, Leming Shi, 2012 .

Prediction of estrogen receptor binding for 58,000 chemicals using an integrated system of a tree-based model with structural alerts.

Weida Tong, Qian Xie, Huixiao Hong, 2001, Environmental health perspectives.

Ionotropic GABA receptor antagonism-induced adverse outcome pathways for potential neurotoxicity biomarkers.

Huixiao Hong, Edward J Perkins, Ping Gong, 2015, Biomarkers in medicine.

Development and Validation of Decision Forest Model for Estrogen Receptor Binding Prediction of Chemicals Using Large Data Sets.

Weida Tong, Huixiao Hong, Heng Luo, 2015, Chemical research in toxicology.

EADB: an estrogenic activity database for assessing potential endocrine activity.

Weida Tong, Huixiao Hong, Hong Fang, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Using Decision Forest to Classify Prostate Cancer Samples on the Basis of SELDI-TOF MS Data: Assessing Chance Correlation and Prediction Confidence

Weida Tong, Qian Xie, Huixiao Hong, 2004, Environmental health perspectives.

Molecular biomarkers: a US FDA effort.

Weida Tong, Huixiao Hong, Leming Shi, 2010, Biomarkers in medicine.

Assessing QSAR Limitations - A Regulatory Perspective

Weida Tong, Qian Xie, Huixiao Hong, 2005 .

Modeling Chemical Interaction Profiles: II. Molecular Docking, Spectral Data-Activity Relationship, and Structure-Activity Relationship Models for Potent and Weak Inhibitors of Cytochrome P450 CYP3A4 Isozyme

Bruce A. Pearce, Laura K. Schnackenberg, Dan A. Buzatu, 2012, Molecules.

Approaches and Practical Considerations for the Analysis of Toxicogenomics Data

Weida Tong, Huixiao Hong, Leming Shi, 2011 .

Predicting hepatotoxicity using ToxCast in vitro bioactivity and chemical structure.

Huixiao Hong, Imran Shah, Richard S Judson, 2015, Chemical research in toxicology.

The Reproducibility of Lists of Differentially Expressed Genes in Microarray Studies

Weida Tong, Qian Xie, Huixiao Hong, 2007 .

Toward predictive models for drug-induced liver injury in humans: are we there yet?

Weida Tong, Huixiao Hong, Hong Fang, 2014, Biomarkers in medicine.

Receptor-Mediated Toxicity: QSARs for Estrogen Receptor Binding and Priority Setting of Potential Estrogenic Endocrine Disruptors

Weida Tong, Qian Xie, Huixiao Hong, 2004 .

CERAPP: Collaborative Estrogen Receptor Activity Prediction Project

Ruili Huang, Igor V. Tetko, Eva Bay Wedebye, 2016, Environmental health perspectives.

Regulatory application of SAR/QSAR for priority setting of endocrine disruptors: A perspective

Weida Tong, Qian Xie, Huixiao Hong, 2003 .

Development of estrogen receptor beta binding prediction model using large sets of chemicals

Chaoyang Zhang, Weida Tong, Huixiao Hong, 2017, Oncotarget.

Technical Reproducibility of Genotyping SNP Arrays Used in Genome-Wide Association Studies

Christophe G. Lambert, Weida Tong, Huixiao Hong, 2012, PloS one.

A Rat α-Fetoprotein Binding Activity Prediction Model to Facilitate Assessment of the Endocrine Disruption Potential of Environmental Chemicals

Weida Tong, Huixiao Hong, Hui Wen Ng, 2016, International journal of environmental research and public health.

Structural Changes Due to Antagonist Binding in Ligand Binding Pocket of Androgen Receptor Elucidated Through Molecular Dynamics Simulations

Weida Tong, Huixiao Hong, Wenjing Guo, 2018, Front. Pharmacol..

Advancing translation of biomarkers into regulatory science.

Huixiao Hong, William Slikker, 2015, Biomarkers in medicine.

microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment.

Huixiao Hong, Si Chen, Lei Guo, 2015, Biomarkers in medicine.

Comprehensive Assessments of RNA-seq by the SEQC Consortium: FDA-Led Efforts Advance Precision Medicine

Weida Tong, Huixiao Hong, Leihong Wu, 2016, Pharmaceutics.

Experimental Data Extraction and in Silico Prediction of the Estrogenic Activity of Renewable Replacements for Bisphenol A

Weida Tong, Huixiao Hong, Joseph F. Stanzione, 2016, International journal of environmental research and public health.

Pathway Analysis Revealed Potential Diverse Health Impacts of Flavonoids that Bind Estrogen Receptors

Weida Tong, Huixiao Hong, Roger Perkins, 2016, International journal of environmental research and public health.

Multiclass Decision Forest--a novel pattern recognition method for multiclass classification in microarray data analysis.

Weida Tong, Qian Xie, Huixiao Hong, 2004, DNA and cell biology.

Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein.

Weida Tong, Huixiao Hong, Hong Fang, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities.

Weida Tong, Huixiao Hong, Hong Fang, 2012, Chemical research in toxicology.

Homology Model and Ligand Binding Interactions of the Extracellular Domain of the Human α4β2 Nicotinic Acetylcholine Receptor

Weida Tong, Huixiao Hong, Heng Luo, 2016 .

Mold2 Molecular Descriptors for QSAR

Svetoslav H. Slavov, Weida Tong, Huixiao Hong, 2012 .

An investigation of biomarkers derived from legacy microarray data for their utility in the RNA-seq era

Weida Tong, Huixiao Hong, Leming Shi, 2014, Genome Biology.

Competitive docking model for prediction of the human nicotinic acetylcholine receptor α7 binding of tobacco constituents

Weida Tong, Huixiao Hong, Leihong Wu, 2018, Oncotarget.

Consensus Modeling for Prediction of Estrogenic Activity of Ingredients Commonly Used in Sunscreen Products

Weida Tong, Huixiao Hong, Chandrabose Selvaraj, 2016, International journal of environmental research and public health.

Estrogenic activity data extraction and in silico prediction show the endocrine disruption potential of bisphenol A replacement compounds.

Weida Tong, Huixiao Hong, Roger Perkins, 2015, Chemical research in toxicology.

Genomic Discoveries and Personalized Medicine in Neurological Diseases

Huixiao Hong, Li Zhang, H. Hong, 2015, Pharmaceutics.

Application of genome analysis strategies in the clinical testing for pediatric diseases

Weida Tong, Huixiao Hong, Baitang Ning, 2018, Pediatric investigation.