Colin Hutton

发表

Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity

C. Jørgensen, S. Zelenay, O. Sansom, 2021, Cancer cell.

First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib.

Bohdan Waszkowycz, Allan M Jordan, J. Tucker, 2016, ACS chemical biology.

A microenvironment-inspired synthetic 3D model for pancreatic ductal adenocarcinoma organoids

L. Griffith, M. Humphries, C. Cintas, 2021, Nature Materials.

Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis

A. Lamarca, J. Valle, Tamara Scheidt, 2021, Nature Communications.

Anti-inflammatory drugs remodel the tumor immune environment to enhance immune checkpoint blockade efficacy.

T. Schumacher, C. Jørgensen, S. Zelenay, 2021, Cancer discovery.

Development and evaluation of selective, reversible LSD1 inhibitors derived from fragments

Mark Cockerill, A. Mirza, J. Blagg, 2013 .

USP7 inactivation suppresses APC-mutant intestinal hyperproliferation and tumor development

F. Ciccarelli, D. Repana, Vivian S. W. Li, 2022, bioRxiv.

Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides.

J. Tucker, B. Waszkowycz, A. Jordan, 2018, Journal of medicinal chemistry.

Abstract C39: First-in-class inhibitors of the putatively undruggable DNA repair target Poly(ADP-ribose) glycohydrolase (PARG)

B. Waszkowycz, A. Jordan, D. Ogilvie, 2015 .