Le Han

发表

A synthetic small molecule for targeted transcriptional activation of germ cell genes in a human somatic cell.

H. Sugiyama, H. Nagase, A. Saha, 2013, Angewandte Chemie.

A Synthetic DNA-Binding Domain Guides Distinct Chromatin-Modifying Small Molecules to Activate an Identical Gene Network.

Yufang Xu, H. Sugiyama, X. Qian, 2015, Angewandte Chemie.

A highly selective and sensitive fluorescence "turn-on" probe for Ag+ in aqueous solution and live cells.

Yufang Xu, X. Qian, Weiping Zhu, 2012, Dalton transactions.

Identification of a small molecule that turns ON the pluripotency gene circuitry in human fibroblasts.

H. Sugiyama, H. Nagase, A. Saha, 2014, ACS chemical biology.

Design, synthesis, X-ray crystallographic analysis, and biological evaluation of thiazole derivatives as potent and selective inhibitors of human dihydroorotate dehydrogenase.

Honglin Li, Xiaofeng Liu, Zhenjiang Zhao, 2015, Journal of medicinal chemistry.

Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screening.

Honglin Li, Jin Huang, Yufang Xu, 2012, Journal of medicinal chemistry.

Rationally designed multitarget anticancer agents.

Yufang Xu, X. Qian, Zhuo Chen, 2013, Current medicinal chemistry.

Distinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts

H. Sugiyama, H. Nagase, A. Saha, 2014, Scientific Reports.

A highly selective and sensitive fluorescence "turn-on" probe for Ag+ in aqueous solution and live cells.

X. Qian, Weiping Zhu, Chu‐Ting Yang, 2012, Dalton transactions.

Title Distinct DNA-based epigenetic switches trigger transcriptionalactivation of silent genes in human dermal fibroblasts

H. Sugiyama, H. Nagase, A. Saha, 2017 .

A Synthetic DNA-Binding Domain Guides Distinct Chromatin-Modifying Small Molecules to Activate an Identical Gene Network.

H. Sugiyama, X. Qian, G. Pandian, 2015, Angewandte Chemie.

A highly selective and sensitive fluorescence "turn-on" probe for Ag+ in aqueous solution and live cells.

X. Qian, Weiping Zhu, Chu‐Ting Yang, 2012, Dalton transactions.