Ruchia Duggal

发表

Accelerated Identification of Cell Active KRAS Inhibitory Macrocyclic Peptides using Mixture Libraries and Automated Ligand Identification System (ALIS) Technology

T. Sawyer, A. Partridge, Pooja Gopal, 2022, Journal of medicinal chemistry.

Rapid label-free cell-based Approach Membrane Permeability Assay using MALDI-hydrogen-deuterium exchange mass spectrometry for peptides.

E. Regalado, I. Mangion, A. Makarov, 2022, Analytica Chimica Acta.

Kinetic solvent isotope effect in steady‐state turnover by CYP19A1 suggests involvement of Compound 1 for both hydroxylation and aromatization steps

S. Sligar, Y. Khatri, A. Luthra, 2014, FEBS letters.

Overcoming Cellular and Systemic Barriers to Design the Next Wave of Peptide Therapeutics

J. Hochman, T. Sawyer, Ruchia Duggal, 2021 .

Cytochrome b5 enhances androgen synthesis by rapidly reducing the CYP17A1 oxy‐complex in the lyase step

S. Sligar, I. Denisov, Ruchia Duggal, 2018, FEBS letters.

Human Cytochrome CYP17A1: The Structural Basis for Compromised Lyase Activity with 17-Hydroxyprogesterone.

Michael C. Gregory, S. Sligar, I. Denisov, 2018, Journal of the American Chemical Society.

Evidence that cytochrome b5 acts as a redox donor in CYP17A1 mediated androgen synthesis.

Michael C. Gregory, S. Sligar, I. Denisov, 2016, Biochemical and biophysical research communications.

Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1.

A. Peier, C. Strickland, Benjamin J Barlock, 2022, Journal of medicinal chemistry.

Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling

A. Peier, P. Orth, C. Verma, 2021, bioRxiv.

Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application to Mdm2/X dual antagonists

J. Hochman, C. Verma, S. Kannan, 2023, bioRxiv.

Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1.

A. Peier, C. Strickland, Benjamin J Barlock, 2021, Journal of medicinal chemistry.

Metabolism and Excretion of Therapeutic Peptides: Current Industry Practices, Perspectives, and Recommendations

Joe R. Cannon, C. Hilgendorf, M. Gunduz, 2023, Drug Metabolism and Disposition.

NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay.

A. Peier, D. Lane, J. Hermes, 2021, ACS chemical biology.

Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists

S. Kannan, H. Kaan, D. Spiegelberg, 2024, Nature communications.