April A Cox

发表

ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor models.

B. Tunquist, D. Walker, C. Lemieux, 2009, Anticancer Research.

Discovery of a Novel Class of Imidazo[1,2-a]Pyridines with Potent PDGFR Activity and Oral Bioavailability.

J. E. Robinson, J. Lyssikatos, R. K. DeLisle, 2014, ACS medicinal chemistry letters.

Qualification and application of a liquid chromatography–tandem mass spectrometric method for the determination of human Aβ1-40 and Aβ1-42 peptides in transgenic mouse plasma using micro-elution solid phase extraction

K. Scearce-Levie, Xingrong Liu, R. Watts, 2013, Archives of Pharmacal Research.

8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors.

K. Scearce-Levie, G. Vigers, Xingrong Liu, 2014, Journal of medicinal chemistry.

Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system.

K. Scearce-Levie, M. Volgraf, G. Vigers, 2014, Journal of medicinal chemistry.

Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species.

G. Vigers, Xingrong Liu, Darin J. Smith, 2013, Journal of medicinal chemistry.

Qualification and application of a liquid chromatography–tandem mass spectrometric method for the determination of human Aβ1-40 and Aβ1-42 peptides in transgenic mouse plasma using micro-elution solid phase extraction

K. Scearce-Levie, Xingrong Liu, R. Watts, 2013, Archives of pharmacal research.

Combination of the KSP Inhibitor ARRY-520 with Bortezomib or Revlimid Causes Sustained Tumor Regressions and Significantly Increased Time to Regrowth in Models of Multiple Myeloma.

B. Tunquist, D. Walker, R. Woessner, 2009 .

447 POSTER ARRY-520, a KSP inhibitor with potent in vitro and in vivo efficacy and pharmacodynamic activity in models of multiple myeloma

B. Tunquist, D. Trawick, D. Walker, 2008 .