Shinji Kumagai

Facile synthesis and fundamental properties of an N-methylguanidine-bridged nucleic acid (GuNA[NMe]).

S. Obika, Takao Yamaguchi, Yutaro Kotobuki, 2018, Organic & biomolecular chemistry.

Structure-Activity Relationships of Anti-microRNA Oligonucleotides Containing Cationic Guanidine-Modified Nucleic Acids.

S. Obika, Masataka Kuroda, K. Yasukawa, 2022, Journal of medicinal chemistry.

Synthesis and properties of GuNA purine/pyrimidine nucleosides and oligonucleotides.

S. Obika, Katsuya Yamada, Takao Yamaguchi, 2020, Organic & biomolecular chemistry.

Mechanism of the extremely high duplex-forming ability of oligonucleotides modified with N-tert-butylguanidine- or N-tert-butyl-N′- methylguanidine-bridged nucleic acids

S. Obika, H. Aoyama, Takao Yamaguchi, 2023, Nucleic acids research.

A Systemically Administered Unconjugated Antisense Oligonucleotide Targeting DUX4 Improves Muscular Injury and Motor Function in FSHD Model Mice

T. Kakimoto, K. Ishikawa, Kumiko Yoshida, 2023, Biomedicines.

Synthesis and properties of a novel modified nucleic acid, 2'-N-methanesulfonyl-2'-amino-locked nucleic acid.

J. Kotera, Takashi Sasaki, S. Obika, 2023, Bioorganic & medicinal chemistry letters.

2'-N-Alkylaminocarbonyl-2'-amino-LNA: Synthesis, duplex stability, nuclease Resistance, and in vitro anti-MicroRNA activity.

S. Obika, Masayuki Utsugi, Norihiko Iwazaki, 2022, Bioorganic & medicinal chemistry.

Facile synthesis and fundamental properties of an N-methylguanidine-bridged nucleic acid (GuNA[NMe]).

S. Obika, Takao Yamaguchi, Yutaro Kotobuki, 2018, Organic & biomolecular chemistry.