Plinio Perrone

Facile one-pot preparation of 2-arylpropionic and arylacetic acids from cyanohydrins by treatment with aqueous HI

A. Amore, M. Allegretti, A. Dolce, 2009 .

The phosphoramidate ProTide approach greatly enhances the activity of beta-2'-C-methylguanosine against hepatitis C virus.

J. Neyts, C. Mcguigan, K. Madela, 2009, Bioorganic & medicinal chemistry letters.

First example of phosphoramidate approach applied to a 4'-substituted purine nucleoside (4'-azidoadenosine): conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus.

C. Mcguigan, S. Le Pogam, K. Klumpp, 2007, Journal of medicinal chemistry.

Application of the phosphoramidate ProTide approach to 4'-azidouridine confers sub-micromolar potency versus hepatitis C virus on an inactive nucleoside.

C. Mcguigan, S. Le Pogam, K. Klumpp, 2007, Journal of medicinal chemistry.

The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4'-azidocytidine (R1479).

C. Mcguigan, S. Le Pogam, K. Klumpp, 2009, Bioorganic & medicinal chemistry letters.