Per-Ola Johansson

发表

Discovery and development of simeprevir (TMC435), a HCV NS3/4A protease inhibitor.

B. Samuelsson, M. Cummings, Magnus Nilsson, 2014, Journal of medicinal chemistry.

Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid-phase synthesis to explore novel statine motifs.

Elizabeth Hamelink, L. Vrang, B. Samuelsson, 2004, Journal of medicinal chemistry.

Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: design, synthesis and X-ray crystal structures of enzyme inhibitor complexes.

Anders Dahlgren, Tatiana Agback, Per-Ola Johansson, 2012, Bioorganic & medicinal chemistry.

Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors.

L. Vrang, B. Samuelsson, Lili Hu, 2008, Bioorganic & medicinal chemistry letters.

Potent inhibitors of the hepatitis C virus NS3 protease: use of a novel P2 cyclopentane-derived template.

Elizabeth Hamelink, L. Vrang, B. Samuelsson, 2006, Bioorganic & medicinal chemistry.

Novel morpholinone-based D-Phe-Pro-Arg mimics as potential thrombin inhibitors: design, synthesis, and X-ray crystal structure of an enzyme inhibitor complex.

B. Samuelsson, D. Musil, I. Nilsson, 2002, Bioorganic & Medicinal Chemistry.

Design and synthesis of potent inhibitors of plasmepsin I and II: X-ray crystal structure of inhibitor in complex with plasmepsin II.

Elizabeth Hamelink, L. Vrang, B. Samuelsson, 2005, Journal of medicinal chemistry.

Highly potent macrocyclic BACE-1 inhibitors incorporating a hydroxyethylamine core: design, synthesis and X-ray crystal structures of enzyme inhibitor complexes.

B. Samuelsson, J. Lindberg, Veronica Sandgren, 2012, Bioorganic & medicinal chemistry.

Novel potent macrocyclic inhibitors of the hepatitis C virus NS3 protease: use of cyclopentane and cyclopentene P2-motifs.

Elizabeth Hamelink, L. Vrang, B. Samuelsson, 2007, Bioorganic & medicinal chemistry.