B. De Crombrugghe

发表

The mouse type-III procollagen-encoding gene: genomic cloning and complete DNA sequence.

P. D. Toman, B. De Crombrugghe, 1994, Gene.

Evidence for two functional gal promoters in intact Escherichia coli cells.

H. Aiba, S. Adhya, B. De Crombrugghe, 1981, The Journal of biological chemistry.

The exon structure of the mouse alpha 2(IX) collagen gene shows unexpected divergence from the chick gene.

E. Vuorio, M. Perälä, K. Elima, 1994, The Journal of biological chemistry.

ATPase activity required for termination of transcription by the Escherichia coli protein factor rho.

B. de Crombrugghe, B. Howard, B. De Crombrugghe, 1976, The Journal of biological chemistry.

Structural and functional studies on the interstitial collagen genes.

M. Mudryj, C. McKeon, C. Setoyama, 1985, Ciba Foundation symposium.

Structure of the promoter for chicken alpha 2 type I collagen gene.

I. Pastan, B. de Crombrugghe, Y. Yamada, 1981, Proceedings of the National Academy of Sciences of the United States of America.

A CCAAT DNA binding factor consisting of two different components that are both required for DNA binding.

E. Van Schaftingen, P. Golumbek, A. Hatamochi, 1988, The Journal of biological chemistry.

Assembly of cartilage collagen fibrils is disrupted by overexpression of normal type II collagen in transgenic mice.

E. Vuorio, W. Horton, J. Ellard, 1993, Proceedings of the National Academy of Sciences of the United States of America.

On the mechanism of action of lac repressor.

I. Pastan, M. Gottesman, W. Anderson, 1971, Nature: New biology.

Studies on the structure of the mouse CBF-A gene and properties of a truncated CBF-A isoform generated from an alternatively spliced RNA.

S. Maity, K. Sohn, B. De Crombrugghe, 1994, Gene.

Separate binding sites for nuclear factor 1 and a CCAAT DNA binding factor in the mouse alpha 2(I) collagen promoter.

J. Oikarinen, A. Hatamochi, B. De Crombrugghe, 1987, The Journal of biological chemistry.

Differential binding of a CCAAT DNA binding factor to the promoters of the mouse alpha 2(I) and alpha 1(III) collagen genes.

B. Paterson, A. Hatamochi, B. De Crombrugghe, 1986, The Journal of biological chemistry.

Point mutations and small substitution mutations in three different upstream elements inhibit the activity of the mouse alpha 2(I) collagen promoter.

G. Karsenty, P. Golumbek, B. De Crombrugghe, 1988, The Journal of biological chemistry.

Release of polarity in Escherichia coli by gene N of phage lambda: termination and antitermination of transcription.

S. Adhya, M. Gottesman, B. De Crombrugghe, 1974, Proceedings of the National Academy of Sciences of the United States of America.

rDlx, a novel distal-less-like homeoprotein is expressed in developing cartilages and discrete neuronal tissues.

X. Zhou, G. Zhao, M. Solursh, 1994, Developmental biology.

Parallel expression of Sox9 and Col2a1 in cells undergoing chondrogenesis

V. Lefebvre, H. Eberspaecher, Qi Zhao, 1997, Developmental dynamics : an official publication of the American Association of Anatomists.

Osteoblast‐Specific Expression of the α2(I) Collagen Promoter in Transgenic Mice: Correlation with the Distribution of TGF‐β1

K. Niederreither, R. D'Souza, B. De Crombrugghe, 1993 .

Minimal DNA sequences that control the cell lineage-specific expression of the pro alpha 2(I) collagen promoter in transgenic mice

K. Niederreither, R. D'Souza, B. De Crombrugghe, 1992, The Journal of cell biology.

Specific hybridization probes for mouse type I, II, III and IX collagen mRNAs.

E. Vuorio, B. de Crombrugghe, M. Metsäranta, 1991, Biochimica et biophysica acta.

Thyroglobulin from human goiters. Effects of iodination on sedimentation and iodoamino acid synthesis.

H. Edelhoch, M. de Visscher, C. Beckers, 1967, The Journal of biological chemistry.

Genetic evidence for the vital function of osterix in cementogenesis

B. de Crombrugghe, Jian Q. Feng, M. Somerman, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Restriction enzyme digestions identify discrete domains in the chromatin around the promoter of the mouse alpha 2(I) collagen gene.

C. Setoyama, G. Liau, D. Szapary, 1986, The Journal of biological chemistry.

Coordinate patterns of expression of type I and III collagens during mouse development.

E. Vuorio, K. Niederreither, R. D'Souza, 1995, Matrix biology : journal of the International Society for Matrix Biology.

Developmental and tissue-specific expression directed by the alpha 2 type I collagen promoter in transgenic mice.

P. Overbeek, H. Westphal, J. Khillan, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Specificity Protein 7 Is Required for Proliferation and Differentiation of Ameloblasts and Odontoblasts

J. C. Clarke, A. Javed, K. Sinha, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Osterix Regulates Tooth Root Formation in a Site-specific Manner

B. de Crombrugghe, E. Cho, C. Bae, 2015, Journal of dental research.

Transcriptional Regulation of Vascular Endothelial Growth Factor (VEGF) by Osteoblast-specific Transcription Factor Osterix (Osx) in Osteoblasts

Hongli Jiao, G. Xiao, Chi Zhang, 2011, Journal of Biological Chemistry.

Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix

Kyucheol Cho, P. McCrea, B. de Crombrugghe, 2008, Proceedings of the National Academy of Sciences.

Some recent advances in the chemistry and biology of transforming growth factor-beta

M. Sporn, L. Wakefield, A. Roberts, 1987, The Journal of cell biology.

The family of collagen genes.

E. Vuorio, B. de Crombrugghe, B. De Crombrugghe, 1990, Annual review of biochemistry.

Type X collagen gene expression in mouse chondrocytes immortalized by a temperature-sensitive simian virus 40 large tumor antigen

V. Lefebvre, S. Garofalo, B. De Crombrugghe, 1995, The Journal of cell biology.

p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling

Qiang Wu, Ke Guo, Huck-Hui Ng, 2006, The Journal of cell biology.

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6.

Marie-Christine Chaboissier, A. Schedl, H. Akiyama, 2002, Genes & development.

Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase

H. Yasuda, S. Dent, K. Sinha, 2009, The EMBO journal.

Positive Regulation of Adult Bone Formation by Osteoblast‐Specific Transcription Factor Osterix

B. de Crombrugghe, Shin-Yoon Kim, H. Akiyama, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The properties of thyroglobulin. XIV. The structure of reoxidized thyroglobulin.

H. Edelhoch, B. De Crombrugghe, B. D. Crombrugghe, 1966, Biochemistry.

Termination and antitermination in transcription: control of gene expression.

S. Adhya, M. Gottesman, B. De Crombrugghe, 1974, Basic life sciences.

Lac DNA, RNA polymerase and cyclic AMP receptor protein, cyclic AMP, lac repressor and inducer are the essential elements for controlled lac transcription.

I. Pastan, M. Gottesman, W. Anderson, 1971, Nature: New biology.

Transforming growth factor beta: biochemistry and roles in embryogenesis, tissue repair and remodeling, and carcinogenesis.

M. Sporn, L. Wakefield, N. Thompson, 1988, Recent progress in hormone research.

Chondrocytes Directly Transform into Bone Cells in Mandibular Condyle Growth

R. Hinton, Y. Jing, J. Jing, 2015, Journal of dental research.

The properties of thyroglobulin. XI. The reduction of the disulfide bonds.

H. Edelhoch, R. Pitt-Rivers, B. De Crombrugghe, 1966, The Journal of biological chemistry.

Chondrodysplasia in transgenic mice harboring a 15-amino acid deletion in the triple helical domain of pro alpha 1(II) collagen chain

E. Vuorio, B. Crombrugghe, G. Decker, 1992, The Journal of cell biology.

Downregulation of rheumatoid arthritis‐related antigen RA‐A47 (HSP47/colligin‐2) in chondrocytic cell lines induces apoptosis and cell‐surface expression of RA‐A47 in association with CD9

B. de Crombrugghe, M. Takigawa, S. Kubota, 2005, Journal of cellular physiology.

Effects of transformation on fibronectin gene expression using cloned fibronectin cDNA.

I. Pastan, J. Fagan, K. Yamada, 1981, The Journal of biological chemistry.

Use of recombinant plasmids to characterize collagen RNAs in normal and transformed chick embryo fibroblasts.

I. Pastan, J. Alwine, S. Adams, 1979, The Journal of biological chemistry.

Determination of the nucleotide sequence of part of the regulatory region for the galactose operon from Escherichia coli.

S. Weissman, J. Sklar, B. de Crombrugghe, 1977, The Journal of biological chemistry.

Type I Collagen

J. Rossert, B. Crombrugghe, B. De Crombrugghe, 2002 .

Ligand-dependent genetic recombination in fibroblasts : a potentially powerful technique for investigating gene function in fibrosis.

C. Denton, C. Black, Zhaoping Zhang, 2002, The American journal of pathology.

Molecular cloning and characterization of a novel rat activin receptor.

B. de Crombrugghe, R. Legerski, P. Segarini, 1992, Biochemical and biophysical research communications.

Connective tissue growth factor causes EMT-like cell fate changes in vivo and in vitro

D. Abraham, J. Norman, S. Sonnylal, 2013, Journal of Cell Science.

The B subunit of a rat heteromeric CCAAT-binding transcription factor shows a striking sequence identity with the yeast Hap2 transcription factor.

B. Crombrugghe, S. Maity, T. Vuorio, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Regulatory mechanisms in the pathways of cartilage and bone formation.

V. Lefebvre, B. Crombrugghe, K. Nakashima, 2001, Current opinion in cell biology.

The transcription factors L-Sox5 and Sox6 are essential for cartilage formation.

V. Lefebvre, R. Behringer, Ping Li, 2001, Developmental cell.

L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway.

V. Lefebvre, R. Behringer, B. De Crombrugghe, 2001, Osteoarthritis and cartilage.

Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization

J. Deng, R. Behringer, W. Bi, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Transcriptional mechanisms of chondrocyte differentiation.

V. Lefebvre, S. Murakami, R. Behringer, 2000, Matrix biology : journal of the International Society for Matrix Biology.

Potent Inhibition of the Master Chondrogenic FactorSox9 Gene by Interleukin-1 and Tumor Necrosis Factor-α*

V. Lefebvre, B. De Crombrugghe, Shunichi Murakami, 2000, The Journal of Biological Chemistry.

A new long form of Sox5 (L‐Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene

Véronique Lefebvre, Ping Li, V. Lefebvre, 1998, The EMBO journal.

Expression pattern and gene characterization of asporin. a newly discovered member of the leucine-rich repeat protein family.

W. Zhou, B. Crombrugghe, R. Mayne, 2001, The Journal of biological chemistry.

Regulation of bone formation and remodeling by G-protein-coupled receptor 48

Jian Luo, Wei Zhou, Zhengfang Yi, 2009, Development.

Separate cis-acting DNA elements of the mouse pro-alpha 1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice

J. Rossert, H. Eberspaecher, B. De Crombrugghe, 1995, The Journal of cell biology.

Genetic regulation of bone mass and susceptibility to osteoporosis.

S. Ralston, B. De Crombrugghe, 2006, Genes & development.

Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors.

J. Deng, R. Behringer, Takashi Nakamura, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Transcriptional mechanisms in osteoblast differentiation and bone formation.

K. Nakashima, B. De Crombrugghe, 2003, Trends in genetics : TIG.

Interactions between Sox9 and beta-catenin control chondrocyte differentiation.

P. McCrea, J. Deng, R. Behringer, 2004, Genes & development.

Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors.

B. Czerniak, B. de Crombrugghe, Wendong Huang, 2003, Human pathology.

SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene

P N Goodfellow, P. Goodfellow, V. Lefebvre, 1997, Molecular and cellular biology.

TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation

B. de Crombrugghe, M. Mattei, Xin Zhou, 1993, Molecular and cellular biology.

Transcriptional suppression of cellular gene expression by c-Myc

B. de Crombrugghe, B. S. Yang, S. Freytag, 1991, Molecular and cellular biology.

Selective activation of transcription by a novel CCAAT binding factor.

G. Karsenty, S. Maity, P. Golumbek, 1988, Science.

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

B. de Crombrugghe, M. Taketo, G. Schett, 2012, Annals of the Rheumatic Diseases.

Regulation or procollagen messenger ribonucleic acid levels in Rous sarcoma virus transformed chick embryo fibroblasts.

I. Pastan, B. de Crombrugghe, T. Yamamoto, 1981, Biochemistry.

Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts.

I. Pastan, B. de Crombrugghe, B. Howard, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Three High Mobility Group-like Sequences within a 48-Base Pair Enhancer of the Col2a1 Gene Are Required for Cartilage-specific Expression in Vivo *

V. Lefebvre, G. Zhou, B. de Crombrugghe, 1998, The Journal of Biological Chemistry.

Transcriptional activation encoded by the v-fos gene.

M. Mudryj, C. Setoyama, G. Liau, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Purification of a novel factor which binds to the mouse α2 (I) collagen promoter

B. de Crombrugghe, T. Krieg, A. Hatamochi, 1993 .

Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest

D. Rowitch, B. de Crombrugghe, H. Akiyama, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Stimulation of lac mRNA synthesis by cyclic AMP in cell free extracts of Escherichia coli.

H. Varmus, I. Pastan, R. Perlman, 1970, Biochemical and biophysical research communications.

Regulation of inducible enzyme synthesis in Escherichia coli by cyclic adenosine 3', 5'-monophosphate.

H. Varmus, I. Pastan, R. Perlman, 1969, The Journal of biological chemistry.

A New Long Form of c-Maf Cooperates with Sox9 to Activate the Type II Collagen Gene*

B. de Crombrugghe, Wendong Huang, H. Eberspaecher, 2002, The Journal of Biological Chemistry.

Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype.

S. Murakami, D. Givol, Zhaoping Zhang, 2004, Genes & development.

Role of the CCAAT-binding protein CBF/NF-Y in transcription.

B. Crombrugghe, S. Maity, B. De Crombrugghe, 1998, Trends in biochemical sciences.

Three different polypeptides are necessary for DNA binding of the mammalian heteromeric CCAAT binding factor.

B. Crombrugghe, E. Ruteshouser, S. Maity, 1992, The Journal of biological chemistry.

Cthrc1 Is a Positive Regulator of Osteoblastic Bone Formation

J. Deng, R. Behringer, K. Kwan, 2008, PloS one.

SOX9 is required for the differentiation of paneth cells in the intestinal epithelium.

Hans Clevers, Johan H van Es, Stanley R Hamilton, 2006, Gastroenterology.

Regulation of lac mRNA synthesis in a soluble cell-free system.

H. Varmus, I. Pastan, M. Gottesman, 1971, Nature: New biology.

Effect of Rho on transcription of bacterial operons.

I. Pastan, S. Adhya, M. Gottesman, 1973, Nature: New biology.

Stimulation by cyclic AMP and ppGpp of chloramphenicol acetyl transferase synthesis.

W. V. Shaw, I. Pastan, J. Rosner, 1973, Nature: New biology.

A sequence conserved in both the chicken and mouse alpha 2(I) collagen promoter contains sites sensitive to S1 nuclease.

B. Crombrugghe, C. McKeon, A. Schmidt, 1984, The Journal of biological chemistry.

A highly conserved enhancer in mammalian type X collagen genes drives high levels of tissue-specific expression in hypertrophic cartilage in vitro and in vivo.

V. Lefebvre, T. Hattori, K. von der Mark, 2004, Matrix biology : journal of the International Society for Matrix Biology.

Transcription of the chicken alpha 2 (Type I) collagen gene by homologous cell-free extracts.

I. Pastan, G. Merlino, J. Tyagi, 1982, The Journal of biological chemistry.

Identification and Characterization of MicroRNAs Controlled by the Osteoblast-Specific Transcription Factor Osterix

Wenbin Liu, B. de Crombrugghe, H. Yasuda, 2013, PloS one.

Coordinate regulation of the levels of type III and type I collagen mRNA in most but not all mouse fibroblasts.

Y. Yamada, G. Liau, B. De Crombrugghe, 1985, The Journal of biological chemistry.

Attenuation of fibrosis in vitro and in vivo with SPARC siRNA

F. Arnett, B. de Crombrugghe, Xiaodong Zhou, 2010, Arthritis research & therapy.

Activation of a fibroblast-specific enhancer of the proalpha2(I) collagen gene in tight-skin mice.

C. Denton, George Bou-Gharios, C. Black, 2001, Arthritis and rheumatism.

SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification

A. Hess, M. Bösl, T. Hattori, 2010, Development.

Regulation of a collagen gene promoter by the product of viral mos oncogene

A. Schmidt, C. Setoyama, B. De Crombrugghe, 1985, Nature.

The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones.

H. Kronenberg, U. Chung, B. Crombrugghe, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Phosphorylation of SOX9 by Cyclic AMP-Dependent Protein Kinase A Enhances SOX9's Ability To Transactivate aCol2a1 Chondrocyte-Specific Enhancer

V. Lefebvre, B. de Crombrugghe, Wendong Huang, 2000, Molecular and Cellular Biology.

Phosphorylation of SOX9 by Cyclic AMP-Dependent Protein Kinase A Enhances SOX9's Ability To Transactivate aCol2a1 Chondrocyte-Specific Enhancer

V. Lefebvre, Wendong Huang, Xin Zhou, 2000, Molecular and Cellular Biology.

Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa.

J. Epstein, D. Rowitch, R. Behringer, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Transforming growth factor‐β isoforms differently stimulate proα2 (I) collagen gene expression during wound healing process in transgenic mice

B. de Crombrugghe, Y. Inagaki, K. Takehara, 2002 .

Transforming growth factor-beta isoforms differently stimulate proalpha2 (I) collagen gene expression during wound healing process in transgenic mice.

Y. Inagaki, K. Takehara, F. Shirasaki, 2002, Journal of cellular physiology.

Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway.

S. Murakami, B. de Crombrugghe, M. Kan, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Sox9‐expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons

J. Deng, R. Behringer, H. Akiyama, 2010, Genesis.

Transcriptional regulation of fibronectin gene by phorbol myristate acetate in hepatoma cells: A negative role for NF‐κB

In‐San Kim, R. Park, Jung‐Hwa Rhew, 2000, Journal of cellular biochemistry.

Dermal transforming growth factor-beta responsiveness mediates wound contraction and epithelial closure.

B. de Crombrugghe, N. Bhowmick, J. Davidson, 2010, The American journal of pathology.

A conserved nucleotide sequence, coding for a segment of the C-propeptide, is found at the same location in different collagen genes.

Y. Yamada, K. Kühn, B. De Crombrugghe, 1983, Nucleic acids research.

Purification and molecular cloning of the "A" chain of a rat heteromeric CCAAT-binding protein. Sequence identity with the yeast HAP3 transcription factor.

B. Crombrugghe, S. Maity, T. Vuorio, 1990, The Journal of biological chemistry.

Toward understanding SOX9 function in chondrocyte differentiation.

V. Lefebvre, B. De Crombrugghe, 1998, Matrix biology : journal of the International Society for Matrix Biology.

The Osterix Transcription Factor Down-Regulates Interleukin-1α Expression in Mouse Osteosarcoma Cells

E. Kleinerman, G. Chakravarty, S. Jia, 2008, Molecular Cancer Research.

Osterix, a transcription factor for osteoblast differentiation, mediates antitumor activity in murine osteosarcoma.

E. Kleinerman, S. Jia, Zhichao Zhou, 2005, Cancer research.

Wnt/ß-catenin-mediated p53 suppression is indispensable for osteogenesis of mesenchymal progenitor cells

B. de Crombrugghe, G. Lozano, S. Xiong, 2021, Cell Death & Disease.

A Novel Regulatory Mechanism of Type II Collagen Expression via a SOX9-dependent Enhancer in Intron 6*

B. de Crombrugghe, H. Yasuda, Di Chen, 2016, The Journal of Biological Chemistry.

A uniquely conserved regulatory signal is found around the translation initiation site in three different collagen genes.

M. Mudryj, Y. Yamada, B. De Crombrugghe, 1983, The Journal of biological chemistry.

Activation of Proalpha2(I) collagen promoter during hepatic fibrogenesis in transgenic mice.

P. Greenwel, George Bou-Gharios, Y. Inagaki, 1998, Biochemical and biophysical research communications.

Characterization of Mesenchymal-Fibroblast Cells Using the Col1a2 Promoter/Enhancer.

George Bou-Gharios, G. Chu, B. De Crombrugghe, 2017, Methods in molecular biology.

Interferon alfa down‐regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice

H. Yamauchi, B. de Crombrugghe, Y. Inagaki, 2003, Hepatology.

Identification of the promoter and first exon of the mouse alpha 1 (III) collagen gene.

M. Mudryj, G. Liau, B. De Crombrugghe, 1985, The Journal of biological chemistry.

Interactions between PIAS Proteins and SOX9 Result in an Increase in the Cellular Concentrations of SOX9*

H. Yasuda, Ren Zhang, T. Hattori, 2006, Journal of Biological Chemistry.

SOX9 directly Regulates CTGF/CCN2 Transcription in Growth Plate Chondrocytes and in Nucleus Pulposus Cells of Intervertebral Disc

B. de Crombrugghe, H. Yasuda, Di Chen, 2015, Scientific Reports.

Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements.

B. de Crombrugghe, L. Bridgewater, T. Ellison, 2003, Nucleic acids research.

Chondrocyte-specific Enhancer Elements in the Col11a2Gene Resemble the Col2a1 Tissue-specific Enhancer*

V. Lefebvre, L. Bridgewater, V Lefebvre, 1998, The Journal of Biological Chemistry.

Fibroblast-specific Expression of a Kinase-deficient Type II Transforming Growth Factor β (TGFβ) Receptor Leads to Paradoxical Activation of TGFβ Signaling Pathways with Fibrosis in Transgenic Mice*

D. Abraham, C. Denton, X. Shi-wen, 2003, Journal of Biological Chemistry.

Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice

Jian Q. Feng, B. Darnay, K. Sinha, 2010, Proceedings of the National Academy of Sciences.

Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice

K. von der Mark, H. Adams, Xin Zhou, 2014, PLoS genetics.

Generation of aggrecan‐CreERT2 knockin mice for inducible Cre activity in adult cartilage

J. Deng, R. Behringer, Zhaoping Zhang, 2009, Genesis.

Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3.

S. Maity, S Sinha, S N Maity, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of Dkk1 gene regulation by the osteoblast-specific transcription factor Osx.

B. de Crombrugghe, Chi Zhang, H. Dai, 2012, Biochemical and biophysical research communications.

The mouse collagen X gene: complete nucleotide sequence, exon structure and expression pattern.

E. Vuorio, B. de Crombrugghe, I. Eerola, 1993, The Biochemical journal.

Determination of functional domains in the C subunit of the CCAAT-binding factor (CBF) necessary for formation of a CBF-DNA complex: CBF-B interacts simultaneously with both the CBF-A and CBF-C subunits to form a heterotrimeric CBF molecule

B. Crombrugghe, S. Maity, I. S. Kim, 1996, Molecular and cellular biology.

Sclerostin is a direct target of osteoblast-specific transcription factor osterix.

B. de Crombrugghe, Chi Zhang, Wanjin Tang, 2010, Biochemical and biophysical research communications.

Cloning and Characterization of a Transcription Factor That Binds to the Proximal Promoters of the Two Mouse Type I Collagen Genes*

B. de Crombrugghe, O. Miyaishi, A. Takeuchi, 1997, The Journal of Biological Chemistry.

The B subunit of the CCAAT box binding transcription factor complex (CBF/NF-Y) is essential for early mouse development and cell proliferation.

J. Deng, R. Behringer, S. Maity, 2003, Cancer research.

Mesenchymal Deletion of Histone Demethylase NO66 in Mice Promotes Bone Formation

J. Deng, R. Behringer, H. Yasuda, 2015, Journal of Bone and Mineral Research.

Joint formation requires muscle formation and contraction.

H. Yasuda, B. De Crombrugghe, 2009, Developmental cell.

BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoter

M. Bösl, T. Hattori, K. von der Mark, 2006, Histochemistry and Cell Biology.

Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5

H. Yasuda, F. Coustry, M. Takigawa, 2008, Nucleic acids research.

Unusual methylation pattern of the alpha 2 (l) collagen gene.

I. Pastan, H. Ohkubo, C. McKeon, 1982, Cell.

Transcriptional control of the mouse alpha 2(I) collagen gene: functional deletion analysis of the promoter and evidence for cell-specific expression

P. Rossi, A. Schmidt, B. De Crombrugghe, 1986, Molecular and cellular biology.

SOX9 Regulates Multiple Genes in Chondrocytes, Including Genes Encoding ECM Proteins, ECM Modification Enzymes, Receptors, and Transporters

S. Liang, H. Yasuda, Yue Lu, 2014, PloS one.

Sp1 and Sp3 Transcription Factors Mediate Interleukin-1β Down-regulation of Human Type II Collagen Gene Expression in Articular Chondrocytes*

Chafik Ghayor, L. Ala‐Kokko, E. Renard, 2003, Journal of Biological Chemistry.

SOX9 exerts a bifunctional effect on type II collagen gene (COL2A1) expression in chondrocytes depending on the differentiation state.

Chafik Ghayor, P. Galéra, Benoit de Crombrugghe, 2003, DNA and cell biology.

An 18-base-pair sequence in the mouse proalpha1(II) collagen gene is sufficient for expression in cartilage and binds nuclear proteins that are selectively expressed in chondrocytes

V. Lefebvre, X. Zhou, S. Maity, 1996, Molecular and cellular biology.

Development of the fetal bone marrow niche and regulation of HSC quiescence and homing ability by emerging osteolineage cells.

B. de Crombrugghe, K. Hirschi, H. Chao, 2014, Cell reports.

A fibroblast-specific factor binds to an upstream negative control element in the promoter of the mouse alpha 1(I) collagen gene.

R. Ravazzolo, G. Karsenty, B. De Crombrugghe, 1991, The Journal of biological chemistry.

Accurate in vitro transcriptional initiation of the chick alpha 2 (Type I) collagen gene.

I. Pastan, B. de Crombrugghe, G. Merlino, 1981, The Journal of biological chemistry.

Decrease in the levels of nuclear RNA precursors for alpha 2 collagen in Rous sarcoma virus transformed fibroblasts.

I. Pastan, E. Avvedimento, Y. Yamada, 1981, Nucleic acids research.

Isolation and characterization of overlapping genomic clones covering the chicken alpha 2 (type I) collagen gene.

I. Pastan, M. Mudryj, V. Avvedimento, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Decreased levels of collagen mRNA in rous sarcoma virus-transformed chick embryo fibroblasts.

I. Pastan, B. Howard, M. Sobel, 1978, The Journal of biological chemistry.

Sox9/Sox6 and Sp1 are involved in the insulin-like growth factor-I-mediated upregulation of human type II collagen gene expression in articular chondrocytes

F. Mallein-Gerin, S. Moslemi, B. Crombrugghe, 2012, Journal of Molecular Medicine.

Mutations in the Escherichia coli operon that define two promoters and the binding site of the cyclic AMP receptor protein.

H. Aiba, S. Busby, B. De Crombrugghe, 1982, Journal of molecular biology.

Interaction site of Escherichia coli cyclic AMP receptor protein on DNA of galactose operon promoters.

M. O'Neill, T. Taniguchi, B. Crombrugghe, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Cyclic AMP receptor protein: role in transcription activation.

H. Buc, B. de Crombrugghe, S. Busby, 1984, Science.

The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template

B. de Crombrugghe, H. Yasuda, F. Coustry, 2010, Nucleic acids research.

Nucleotide sequence of the operator-promoter region of the galactose operon of Escherichia coli.

R. di Lauro, M. Rosenberg, R. Musso, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Structure and function of the promoter-enhancer region of polyoma and SV40.

M. Yaniv, M. Katinka, S. Cereghini, 1983, Cold Spring Harbor symposia on quantitative biology.

Three classes of mutations in the A subunit of the CCAAT-binding factor CBF delineate functional domains involved in the three-step assembly of the CBF-DNA complex

S. Maity, I. S. Kim, K. Sohn, 1996, Molecular and cellular biology.

Studies on Transcription Activation by the Multimeric CCAAT-binding Factor CBF (*)

F. Coustry, S. Maity, B. De Crombrugghe, 1995, The Journal of Biological Chemistry.

A Gene for a Novel Zinc-finger Protein Expressed in Differentiated Epithelial Cells and Transiently in Certain Mesenchymal Cells*

Michael F. Seldin, M. Seldin, B. de Crombrugghe, 1996, The Journal of Biological Chemistry.

DNA Binding Specificity of the CCAAT-binding Factor CBF/NF-Y*

F. Coustry, S. Maity, Ling-Chia Wu, 1997, The Journal of Biological Chemistry.

Purification, characterization, and role of CCAAT-binding factor in transcription.

S. Maity, B. De Crombrugghe, 1996, Methods in enzymology.

Isolation and characterization of a genomic clone encoding chick alpha 1 type III collagen.

M. Mudryj, Y. Yamada, M. Sullivan, 1983, The Journal of biological chemistry.

Construction of a recombinant bacterial plasmid containing pro-alpha 1(I) collagen DNA sequences.

I. Pastan, B. Olsen, T. Yamamoto, 1980, The Journal of biological chemistry.

DNA sequence comparison of the regulatory signals at the 5' end of the mouse and chick alpha 2 type I collagen genes.

Y. Yamada, A. Schmidt, B. De Crombrugghe, 1984, The Journal of biological chemistry.

Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation.

S. Murakami, B. de Crombrugghe, Ren Zhang, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Expression Pattern and Gene Characterization ofAsporin

W. Zhou, R. Mayne, M. Höök, 2001, The Journal of Biological Chemistry.

Tenascin-W inhibits proliferation and differentiation of preosteoblasts during endochondral bone formation.

H. Akiyama, Takashi Nakamura, Hiroaki Kimura, 2007, Biochemical and biophysical research communications.

Cartilage homeoprotein 1, a homeoprotein selectively expressed in chondrocytes.

B. de Crombrugghe, B. Crombrugghe, X. Zhou, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Attenuation of Expression of Extracellular Matrix Genes with siRNAs to SPARC and CTGF in Skin Fibroblasts of CTGF Transgenic Mice

F. Arnett, B. de Crombrugghe, B. Crombrugghe, 2011, International journal of immunopathology and pharmacology.

Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma.

R. Behringer, B. de Crombrugghe, C. Denton, 2007, Arthritis and rheumatism.

FGF signaling antagonizes cytokine-mediated repression of Sox9 in SW1353 chondrosarcoma cells.

B. de Crombrugghe, L. Buckbinder, J. Schaefer, 2003, Osteoarthritis and cartilage.

Osteoarthritis-like lesions in transgenic mice harboring a small deletion mutation in type II collagen gene.

E. Vuorio, B. de Crombrugghe, H. Salminen, 2000, Osteoarthritis and cartilage.

Chondrocyte-specific ablation of Osterix leads to impaired endochondral ossification.

Seung-Yoon Park, Jung-Eun Kim, B. De Crombrugghe, 2012, Biochemical and biophysical research communications.

Specific expression of Cre recombinase in hypertrophic cartilage under the control of a BAC-Col10a1 promoter.

M. Bösl, T. Hattori, K. von der Mark, 2008, Matrix biology : journal of the International Society for Matrix Biology.

The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site.

L. Bridgewater, H. Akiyama, M. Fellous, 2005, Matrix biology : journal of the International Society for Matrix Biology.

Identification of SOX9 Interaction Sites in the Genome of Chondrocytes

Shoudan Liang, Jiexin Zhang, S. Liang, 2010, PloS one.

CBF/NF-Y functions both in nucleosomal disruption and transcription activation of the chromatin-assembled topoisomerase IIalpha promoter. Transcription activation by CBF/NF-Y in chromatin is dependent on the promoter structure.

F. Coustry, S. Maity, Q. Hu, 2001, The Journal of biological chemistry.

Postnatally induced inactivation of Osterix in osteoblasts results in the reduction of bone formation and maintenance.

Jung-Eun Kim, W. Baek, B. De Crombrugghe, 2010, Bone.

The postnatal role of Sox9 in cartilage

B. de Crombrugghe, S. Liang, K. Akdemir, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice.

Philip A Beachy, T. Ishii, P. Beachy, 2007, Matrix biology : journal of the International Society for Matrix Biology.

A 182 bp fragment of the mouse pro alpha 1(II) collagen gene is sufficient to direct chondrocyte expression in transgenic mice.

V. Lefebvre, G. Zhou, H. Eberspaecher, 1995, Journal of cell science.

Sp7 and Runx2 molecular complex synergistically regulate expression of target genes

Hengbin Wang, B. de Crombrugghe, A. Javed, 2014, Connective tissue research.

Characterization of primary cultures of chondrocytes from type II collagen/beta-galactosidase transgenic mice.

V. Lefebvre, E. Vuorio, M. Metsäranta, 1994, Matrix biology : journal of the International Society for Matrix Biology.

Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.

B. de Crombrugghe, C. V. Van Pelt, D. Abraham, 2010, Arthritis and rheumatism.

Characterization of an Evolutionarily Conserved Far-upstream Enhancer in the Human α2(I) Collagen (COL1A2) Gene*

C. Denton, D. Wells, George Bou-Gharios, 2001, The Journal of Biological Chemistry.

Bacteriophage lambda hin function. II. Enhanced stability of lambda messenger RNA.

D Court, D. Court, S. Adhya, 1980, Journal of molecular biology.

The 5'-terminal nucleotide sequence of galactose messenger ribonucleic acid of Escherichia coli.

I. Pastan, S. Weissman, J. Sklar, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Transcription in vitro of bacteriophage lambda 4S RNA: studies on termination and rho protein.

B. Howard, M. Rosenberg, B. De Crombrugghe, 1977, Nucleic acids research.

Chicken embryo extracts contain a factor that preferentially blocks the accumulation of RNA polymerase II transcripts in a cell-free system.

I. Pastan, G. Merlino, J. Tyagi, 1982, The Journal of biological chemistry.

Twisted Gastrulation Modulates Bone Morphogenetic Protein-induced Collagen II and X Expression in Chondrocytes in Vitro and in Vivo*

M. Stock, T. Hattori, K. von der Mark, 2006, Journal of Biological Chemistry.

Transgenic mice expressing a ligand-inducible cre recombinase in osteoblasts and odontoblasts: a new tool to examine physiology and disease of postnatal bone and tooth.

B. de Crombrugghe, Jung-Eun Kim, K. Nakashima, 2004, The American journal of pathology.

Biochemical analysis of the B subunit of the heteromeric CCAAT-binding factor. A DNA-binding domain and a subunit interaction domain are specified by two separate segments.

S. Maity, B. De Crombrugghe, B. Crombrugghe, 1992, The Journal of biological chemistry.

Enhanced type III collagen gene expression during bleomycin induced lung fibrosis.

B. de Crombrugghe, R. McAnulty, P. Jeffery, 1993, Thorax.

Osterix is required for cranial neural crest-derived craniofacial bone formation.

B. de Crombrugghe, Jung-Eun Kim, W. Baek, 2013, Biochemical and biophysical research communications.

Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor.

S. Maity, M. F. Seldin, S. Sinha, 1996, Genomics.

Evidence for three major transcription activation elements in the proximal mouse proalpha2(I) collagen promoter.

B. de Crombrugghe, X. Zhou, E. Ruteshouser, 1996, Nucleic acids research.

Parathyroid hormone and prostaglandin E2 preferentially increase luciferase levels in bone of mice harboring a luciferase transgene controlled by elements of the pro-alpha1(I) collagen promoter.

G. Rodan, E. Opas, J. Rossert, 2000, Bone.

The exon/intron structure of the 3'-region of the pro alpha 2(I) collagen gene.

I. Pastan, B. Olsen, E. Eikenberry, 1981, The Journal of biological chemistry.

Specific hybridization probes for mouse alpha 2(IX) and alpha 1(X) collagen mRNAs.

E. Vuorio, I. Eerola, M. Perälä, 1992, Biochimica et Biophysica Acta.

Mouse type II collagen gene. Complete nucleotide sequence, exon structure, and alternative splicing.

E. Vuorio, M. Metsäranta, D. Toman, 1991, The Journal of biological chemistry.

E6-AP/UBE3A Protein Acts as a Ubiquitin Ligase toward SOX9 Protein*

B. de Crombrugghe, H. Yasuda, M. Takigawa, 2013, The Journal of Biological Chemistry.

Construction of a recombinant bacterial plasmid containing a chick pro-alpha2 collagen gene sequence.

I. Pastan, B. de Crombrugghe, T. Yamamoto, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Purification and functional characterization of a DNA-binding protein that interacts with a negative element in the mouse alpha 1(I) collagen promoter.

R. Ravazzolo, G. Karsenty, B. De Crombrugghe, 1991, Journal of Biological Chemistry.

Two different negative and one positive regulatory factors interact with a short promoter segment of the alpha 1 (I) collagen gene.

B. de Crombrugghe, G. Karsenty, B. De Crombrugghe, 1990, The Journal of biological chemistry.

Characterization of two distinct positive cis-acting elements in the mouse alpha 1 (III) collagen promoter.

E. Ruteshouser, B. De Crombrugghe, 1989, The Journal of biological chemistry.

Identification of a minimal sequence of the mouse pro-alpha 1(I) collagen promoter that confers high-level osteoblast expression in transgenic mice and that binds a protein selectively present in osteoblasts.

B. de Crombrugghe, J. Rossert, H. Eberspaecher, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Use of a New Rat Chondrosarcoma Cell line to Delineate a 119-Base Pair Chondrocyte-specific Enhancer Element and to Define Active Promoter Segments in the Mouse Pro-α1(II) Collagen Gene (*)

V. Lefebvre, J. Kimura, K. Mukhopadhyay, 1995, The Journal of Biological Chemistry.

Developmental expression of a type II collagen/β‐galactosidase fusion gene in transgenic mice

E. Vuorio, K. Niederreither, M. Metsäranta, 1995, Developmental dynamics : an official publication of the American Association of Anatomists.

Isolation of genomic DNA clones spanning the entire fibronectin gene.

I. Pastan, B. de Crombrugghe, K. Yamada, 1983, Proceedings of the National Academy of Sciences of the United States of America.

The B Subunit of the CAAT-binding Factor NFY Binds the Central Segment of the Co-activator p300*

G. Condorelli, M. C. Faniello, F. Costanzo, 1999, The Journal of Biological Chemistry.

Control of expression of genetic information in E. coli by cyclic AMP.

I. Pastan, B. De Crombrugghe, 1972, Acta endocrinologica. Supplementum.

Persistent Low Level of Osterix Accelerates Interleukin-6 Production and Impairs Regeneration after Tissue Injury

B. de Crombrugghe, Seung-Yoon Park, K. Park, 2013, PloS one.

A repetitive structure in the chick alpha 2-collagen gene.

I. Pastan, M. Mudryj, Y. Yamada, 1981, Cold Spring Harbor Symposia on Quantitative Biology.

Osteoblast-Specific Overexpression of Nucleolar Protein NO66/RIOX1 in Mouse Embryos Leads to Osteoporosis in Adult Mice

R. Krahe, K. Sinha, Qin Chen, 2023, Journal of osteoporosis.

Expression of master regulatory genes controlling skeletal development in benign cartilage and bone forming tumors.

B. Czerniak, J. Bondaruk, Sangkyou Lee, 2010, Human pathology.

Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice.

H. Yamauchi, Y. Inagaki, A. Nakao, 2003 .

Deletion analysis of the mouse alpha 1(III) collagen promoter.

B. de Crombrugghe, M. Mudryj, B. De Crombrugghe, 1988, Nucleic acids research.

Identification of a cell-specific transcriptional enhancer in the first intron of the mouse alpha 2 (type I) collagen gene.

P. Rossi, B. De Crombrugghe, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Primary structure of the carbohydrate‐containing regions of the carboxyl propeptides of type I procollagen

B. Olsen, E. Eikenberry, L. Dickson, 1981, FEBS letters.

Regulation of the expression of genes encoding types I, II, and III collagen during chick embryonic development.

I. Pastan, G. Merlino, B. Crombrugghe, 1983, The Journal of biological chemistry.

Transcriptional Mechanisms Controlling Types I and III Collagen Genes

B. de Crombrugghe, G. Karsenty, P. Rossi, 1990, Annals of the New York Academy of Sciences.

Transcriptional control mechanisms for the expression of type I collagen genes.

G. Karsenty, H. Goldberg, S. Maity, 1991, Annals of the rheumatic diseases.

Promoter sequences of murine alpha A crystallin, murine alpha 2(I) collagen or of avian sarcoma virus genes linked to the bacterial chloramphenicol acetyl transferase gene direct tissue-specific patterns of chloramphenicol acetyl transferase expression in transgenic mice.

J. Piatigorsky, P. Overbeek, K. Bernstein, 1985, Cold Spring Harbor symposia on quantitative biology.

The Transcriptional Activity of the CCAAT-binding Factor CBF Is Mediated by Two Distinct Activation Domains, One in the CBF-B Subunit and the Other in the CBF-C Subunit*

S. Sinha, F. Coustry, S. Maity, 1996, The Journal of Biological Chemistry.

CBF/NF-Y Functions Both in Nucleosomal Disruption and Transcription Activation of the Chromatin-assembled Topoisomerase IIα Promoter

F. Coustry, S. Maity, Q. Hu, 2001, Journal of Biological Chemistry.

cDNA library screening using the SOS recruitment system.

G. Lozano, B. De Crombrugghe, W. Huang, 2001, BioTechniques.

Conservation of the sizes of 53 introns and over 100 intronic sequences for the binding of common transcription factors in the human and mouse genes for type II procollagen (COL2A1).

E. Vuorio, K. Kivirikko, D. Prockop, 1995, Biochemical Journal.

Mini-review Some Recent Advances in the Chemistry and Biology of Transforming Growth Factor-beta Chemical Structure of Tgf-beta

M. Sporn, L. Wakefield, A. Roberts, 2022 .

β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

M. Taketo, G. Schett, O. Distler, 2012, Annals of the rheumatic diseases.

Transcriptional Regulation of Vascular Endothelial Growth Factor (VEGF) by Osteoblast-specific Transcription Factor Osterix (Osx) in Osteoblasts*

Hongli Jiao, G. Xiao, Chi Zhang, 2011, The Journal of Biological Chemistry.

Tissue-specific expression of the mouse alpha 2(I) collagen promoter. Studies in transgenic mice and in tissue culture cells.

G. Karsenty, H. Goldberg, S. Maity, 1992, The Journal of biological chemistry.

Specific expression of Cre recombinase in hypertrophic cartilage under the control of a BAC-Col10a1 promoter.

M. Bösl, T. Hattori, K. von der Mark, 2008, Matrix biology : journal of the International Society for Matrix Biology.

Interactions of RNA polymerase and the cyclic AMP receptor protein on DNA of the E. coli galactose operon.

T. Taniguchi, B. De Crombrugghe, 1983, Nucleic acids research.

Structural Insights into Histone Demethylase NO66 in Interaction with Osteoblast-specific Transcription Factor Osterix and Gene Repression*

J. Zang, K. Sinha, Bin Hu, 2013, The Journal of Biological Chemistry.