Wei-wei Liu

M. Li, Jing Han, Yunjing Li, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Inhibiting NF-κB activation and ROS production are involved in the mechanism of silibinin's protection against D-galactose-induced senescence

T. Ikejima, S. Onodera, S. Tashiro, 2011, Pharmacology Biochemistry and Behavior.

Concentration-dependent dual effects of silibinin on kanamycin-induced cells death in Staphylococcus aureus.

T. Ikejima, S. Onodera, S. Tashiro, 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Protective effects of silibinin against ethanol- or acetaldehyde-caused damage in liver cell lines involve the repression of mitochondrial fission.

T. Ikejima, Toshihiko Hayashi, K. Mizuno, 2022, Toxicology in vitro : an international journal published in association with BIBRA.

Silibinin relieves UVB-induced apoptosis of human skin cells by inhibiting the YAP-p73 pathway

T. Ikejima, Can Li, Weiwei Liu, 2021, Acta pharmacologica Sinica.

Effect of silibinin on ethanol- or acetaldehyde-induced damge of mouse primary hepatocytes in vitro.

T. Ikejima, Weiwei Liu, Toshihiko Hayashi, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

Silibinin-induced apoptosis of breast cancer cells involves mitochondrial impairment.

T. Ikejima, S. Onodera, Weiwei Liu, 2019, Archives of biochemistry and biophysics.

Dual effects of silibinin treatment on autophagy-regulated dermal apoptosis retardation and epidermal apoptosis up-regulation in UVB-induced skin inflammation

T. Ikejima, S. Onodera, S. Tashiro, 2012, Journal of Asian natural products research.

Sub‐lethal ultraviolet B irradiation and Poly I:C treatment synergistically induced apoptosis of HaCaT cells through NF‐&kgr;B pathway

T. Ikejima, S. Onodera, S. Tashiro, 2018, Molecular immunology.

Preparation of enteric-coated microcapsules of astaxanthin oleoresin by complex coacervation

Rencai Chen, Jing Han, Cuiying Qin, 2018, Pharmaceutical development and technology.

Silibinin treatment protects human skin cells from UVB injury through upregulation of estrogen receptors.

T. Ikejima, S. Onodera, Can Li, 2021, Journal of photochemistry and photobiology. B, Biology.

Reactive oxygen species are responsible for the cell aggregation and production of pro-inflammatory mediators in phorbol ester (PMA)-treated U937 cells on gelatin-coated dishes through upregulation of autophagy

W. Liu, M. Yamato, T. Ikejima, 2018, Connective tissue research.

Antiproliferative chromone derivatives induce K562 cell death through endogenous and exogenous pathways

Fanxing Xu, H. Hua, Zhanlin Li, 2020, Journal of enzyme inhibition and medicinal chemistry.

Collagen gel protects L929 cells from TNFα-induced death by activating NF-κB

T. Ikejima, S. Onodera, S. Tashiro, 2017, Connective tissue research.

Reactive oxygen species H2O2 and •OH, but not O2•(-) promote oridonin-induced phagocytosis of apoptotic cells by human histocytic lymphoma U937 cells.

T. Ikejima, S. Onodera, L. Zang, 2013, International immunopharmacology.

Type I collagen reduces lipid accumulation during adipogenesis of preadipocytes 3T3-L1 via the YAP-mTOR-autophagy axis.

T. Ikejima, Weiwei Liu, Toshihiko Hayashi, 2022, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Type I collagen or gelatin stimulates mouse peritoneal macrophages to aggregate and produce pro-inflammatory molecules through upregulated ROS levels.

T. Ikejima, S. Onodera, Weiwei Liu, 2019, International immunopharmacology.

p53-mediated autophagy adjustment is involved in the protection of silibinin against murine dermal inflammation and epidermal apoptosis induced by UVB irradiation

T. Ikejima, S. Onodera, S. Tashiro, 2013, Journal of Asian natural products research.

Silibinin’s regulation of proliferation and collagen gene expressions of rat pancreatic β-cells cultured on types I and V collagen involves β-catenin nuclear translocation

T. Ikejima, S. Onodera, S. Tashiro, 2019, Connective tissue research.

Silibinin relieves UVB-induced apoptosis of human skin cells by inhibiting the YAP-p73 pathway

Fang Wang, T. Ikejima, Can Li, 2021, Acta Pharmacologica Sinica.

Nitric oxide augments oridonin-induced efferocytosis by human histocytic lymphoma U937 cells via autophagy and the NF-κB-COX-2-IL-1β pathway

T. Ikejima, S. Onodera, L. Zang, 2012, Free radical research.

Type I collagen inhibits adipogenic differentiation via YAP activation in vitro

T. Ikejima, S. Onodera, Xiaoling Liu, 2020, Journal of cellular physiology.

Collagens I and V differently regulate the proliferation and adhesion of rat islet INS-1 cells through the integrin β1/E-cadherin/β-catenin pathway

T. Ikejima, Fanxing Xu, Toshihiko Hayashi, 2020, Connective tissue research.

Impaired mitophagy causes mitochondrial DNA leakage and STING activation in ultraviolet B-irradiated human keratinocytes HaCaT.

T. Ikejima, Can Li, Toshihiko Hayashi, 2023, Archives of biochemistry and biophysics.

Nitric oxide induces apoptosis and autophagy; autophagy down-regulates NO synthesis in physalin A-treated A375-S2 human melanoma cells.

T. Ikejima, S. Onodera, L. Zang, 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Silibinin protects murine fibroblast L929 cells from UVB‐induced apoptosis through the simultaneous inhibition of ATM‐p53 pathway and autophagy

T. Ikejima, S. Onodera, L. Zang, 2013, The FEBS journal.

Autophagy induced by silibinin protects human epidermoid carcinoma A431 cells from UVB-induced apoptosis.

T. Ikejima, S. Onodera, S. Tashiro, 2013, Journal of photochemistry and photobiology. B, Biology.

Physalin A induces apoptotic cell death and protective autophagy in HT1080 human fibrosarcoma cells.

T. Ikejima, S. Onodera, S. Tashiro, 2013, Journal of natural products.

DNA damage-triggered activation of cGAS-STING pathway induces apoptosis in human keratinocyte HaCaT cells.

T. Ikejima, Can Li, Weiwei Liu, 2021, Molecular immunology.

Prostaglandin E2 attenuates synergistic bactericidal effects between COX inhibitors and antibiotics on Staphylococcus aureus.

T. Ikejima, S. Onodera, S. Tashiro, 2018, Prostaglandins, leukotrienes, and essential fatty acids.

Activated toll‐like receptor 4 is involved in oridonin‐induced phagocytosis via promotion of migration and autophagy‐lysosome pathway in RAW264.7 macrophages

T. Ikejima, S. Onodera, S. Tashiro, 2019, International immunopharmacology.

Differential levels of reactive oxygen species in murine preadipocyte 3T3-L1 cells cultured on type I collagen molecule-coated and gel-covered dishes exert opposite effects on NF-κB-mediated proliferation and migration

M. Yamato, T. Ikejima, S. Onodera, 2018, Free radical research.

Negatively-regulated necroptosis by autophagy required caspase-6 activation in TNFα-treated murine fibrosarcoma L929 cells.

T. Ikejima, S. Onodera, S. Tashiro, 2013, International immunopharmacology.

Persistent IKK&agr; phosphorylation induced apoptosis in UVB and Poly I:C co‐treated HaCaT cells plausibly through pro‐apoptotic p73 and abrogation of I&kgr;B&agr;

T. Ikejima, S. Onodera, S. Tashiro, 2018, Molecular immunology.

ERβ up-regulation was involved in silibinin-induced growth inhibition of human breast cancer MCF-7 cells.

T. Ikejima, S. Onodera, L. Zang, 2016, Archives of biochemistry and biophysics.

Type I collagen-induced YAP nuclear expression promotes primary cilia growth and contributes to cell migration in confluent mouse embryo fibroblast 3T3-L1 cells

M. Yamato, T. Ikejima, S. Onodera, 2018, Molecular and Cellular Biochemistry.

Type I collagen promotes primary cilia growth through down-regulating HDAC6-mediated autophagy in confluent mouse embryo fibroblast 3T3-L1 cells.

M. Yamato, T. Ikejima, S. Tashiro, 2018, Journal of bioscience and bioengineering.

Silibinin ameliorates anxiety/depression-like behaviors in amyloid β-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus

T. Ikejima, Xiaoyu Song, S. Tashiro, 2017, Physiology & Behavior.

ERα down-regulation plays a key role in silibinin-induced autophagy and apoptosis in human breast cancer MCF-7 cells.

Ye Zhang, T. Ikejima, S. Onodera, 2015, Journal of pharmacological sciences.

Type I collagen induces mesenchymal cell differentiation into myofibroblasts through YAP-induced TGF-β1 activation.

M. Yamato, T. Ikejima, S. Tashiro, 2018, Biochimie.

Marine-Derived Natural Lead Compound Disulfide-Linked Dimer Psammaplin A: Biological Activity and Structural Modification

Fanxing Xu, Weiwei Liu, H. Hua, 2019, Marine drugs.

Type I collagen-induced YAP nuclear expression promotes primary cilia growth and contributes to cell migration in confluent mouse embryo fibroblast 3T3-L1 cells

M. Yamato, T. Ikejima, S. Onodera, 2018, Molecular and Cellular Biochemistry.

Silibinin ameliorates STZ-induced impairment of memory and learning by up- regulating insulin signaling pathway and attenuating apoptosis

T. Ikejima, S. Onodera, Weiwei Liu, 2020, Physiology & Behavior.

Silibinin ameliorates depression/anxiety-like behaviors of Parkinson's disease mouse model and is associated with attenuated STING-IRF3-IFN-β pathway activation and neuroinflammation

T. Ikejima, Weiwei Liu, Toshihiko Hayashi, 2021, Physiology & Behavior.

Silibinin protects Staphylococcus aureus from UVC-induced bactericide via enhanced generation of reactive oxygen species

T. Ikejima, S. Tashiro, Toshihiko Hayashi, 2017 .

Staphylococcus aureus from UVC-induced bactericide via enhanced generation of reactive oxygen species

T. Ikejima, Toshihiko Hayashi, Guo-Dong Yao, 2017 .

Attenuating effect of silibinin on palmitic acid-induced apoptosis and mitochondrial dysfunction in pancreatic β-cells is mediated by estrogen receptor alpha

T. Ikejima, S. Onodera, Jing Yang, 2019, Molecular and Cellular Biochemistry.

Natural flavonoid silibinin promotes the migration and myogenic differentiation of murine C2C12 myoblasts via modulation of ROS generation and down-regulation of estrogen receptor α expression

T. Ikejima, Toshihiko Hayashi, K. Mizuno, 2020, Molecular and Cellular Biochemistry.

Natural flavonoid silibinin promotes the migration and myogenic differentiation of murine C2C12 myoblasts via modulation of ROS generation and down-regulation of estrogen receptor α expression

T. Ikejima, Xiaoling Liu, Weiwei Liu, 2020, Molecular and Cellular Biochemistry.

Involvement of estrogen receptors in silibinin protection of pancreatic β-cells from TNFα- or IL-1β-induced cytotoxicity.

T. Ikejima, S. Onodera, S. Tashiro, 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

In vivo recovery effect of silibinin treatment on streptozotocin-induced diabetic mice is associated with the modulations of sirt-1 expression and autophagy in pancreatic β-cell

T. Ikejima, S. Onodera, S. Tashiro, 2012, Journal of Asian natural products research.

Gelatin promotes cell aggregation and pro-inflammatory cytokine production in PMA-stimulated U937 cells by augmenting endocytosis-autophagy pathway.

W. Liu, M. Yamato, T. Ikejima, 2018, The international journal of biochemistry & cell biology.

Silibinin attenuates motor dysfunction in a mouse model of Parkinson's disease by suppression of oxidative stress and neuroinflammation along with promotion of mitophagy

T. Ikejima, Toshihiko Hayashi, K. Mizuno, 2021, Physiology & Behavior.

Oral Administration of Silibinin Ameliorates Cognitive Deficits of Parkinson’s Disease Mouse Model by Restoring Mitochondrial Disorders in Hippocampus

T. Ikejima, Toshihiko Hayashi, K. Mizuno, 2021, Neurochemical Research.

Inhibition of GluN2B pathway is involved in the neuroprotective effect of silibinin on streptozotocin-induced Alzheimer's disease models.

T. Ikejima, Toshihiko Hayashi, K. Mizuno, 2022, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Increased mitochondrial fission induces NLRP3/cGAS-STING mediated pro-inflammatory pathways and apoptosis in UVB-irradiated immortalized human keratinocyte HaCaT cells.

T. Ikejima, Can Li, Toshihiko Hayashi, 2023, Archives of biochemistry and biophysics.

Enhanced migration of murine fibroblast-like 3T3-L1 preadipocytes on type I collagen-coated dish is reversed by silibinin treatment

M. Yamato, T. Ikejima, S. Onodera, 2018, Molecular and Cellular Biochemistry.

Silibinin inhibits migration and invasion of breast cancer MDA-MB-231 cells through induction of mitochondrial fusion

T. Ikejima, S. Onodera, Toshihiko Hayashi, 2019, Molecular and Cellular Biochemistry.

Silibinin ameliorates amylin-induced pancreatic β-cell apoptosis partly via upregulation of GLP-1R/PKA pathway

T. Ikejima, S. Onodera, S. Tashiro, 2018, Molecular and Cellular Biochemistry.

Silibinin protects rat pancreatic β‐cell through up‐regulation of estrogen receptors' signaling against amylin‐ or Aβ1–42‐induced reactive oxygen species/reactive nitrogen species generation

T. Ikejima, S. Onodera, S. Tashiro, 2019, Phytotherapy research : PTR.

Silibinin-induced mitochondria fission leads to mitophagy, which attenuates silibinin-induced apoptosis in MCF-7 and MDA-MB-231 cells.

T. Ikejima, S. Onodera, Toshihiko Hayashi, 2020, Archives of biochemistry and biophysics.

Silibinin-induced autophagy mediated by PPARα-sirt1-AMPK pathway participated in the regulation of type I collagen-enhanced migration in murine 3T3-L1 preadipocytes

M. Yamato, T. Ikejima, S. Onodera, 2018, Molecular and Cellular Biochemistry.

Autophagy promotes apoptosis induction through repressed nitric oxide generation in the treatment of human breast cancer MCF-7 cells with L-A03, a dihydroartemisinin derivative

T. Ikejima, Jing Yang, Toshihiko Hayashi, 2017, Medicinal Chemistry Research.

Hydrogen sulfide releasing oridonin derivatives induce apoptosis through extrinsic and intrinsic pathways.

Fanxing Xu, Weiwei Liu, Shengtao Xu, 2019, European journal of medicinal chemistry.

IGF-1R/YAP signaling pathway is involved in collagen V-induced insulin biosynthesis and secretion in rat islet INS-1 cells

T. Ikejima, Fanxing Xu, Weiwei Liu, 2022, Connective tissue research.

Oridonin induces apoptosis and autophagy in murine fibrosarcoma L929 cells partly via NO-ERK-p53 positive-feedback loop signaling pathway

T. Ikejima, S. Onodera, S. Tashiro, 2012, Acta Pharmacologica Sinica.

Metformin protects Escherichia coli from bleomycin-induced bactericide via enhanced generation of hydrogen peroxide

T. Ikejima, S. Onodera, Toshihiko Hayashi, 2020, Free radical research.

Silibinin-induced autophagy mediated by PPARα-sirt1-AMPK pathway participated in the regulation of type I collagen-enhanced migration in murine 3T3-L1 preadipocytes

M. Yamato, T. Ikejima, S. Onodera, 2018, Molecular and Cellular Biochemistry.

Silibinin negatively contributes to primary cilia length via autophagy regulated by histone deacetylase 6 in confluent mouse embryo fibroblast 3T3-L1 cells

T. Ikejima, S. Onodera, S. Tashiro, 2016, Molecular and Cellular Biochemistry.

Type I collagen gel protects murine fibrosarcoma L929 cells from TNFα-induced cell death.

T. Ikejima, S. Onodera, S. Tashiro, 2015, Biochemical and biophysical research communications.

Phorbol ester (PMA)‐treated U937 cells cultured on type I collagen‐coated dish express a lower production of pro‐inflammatory cytokines through lowered ROS levels in parallel with cell aggregate formation

M. Yamato, T. Ikejima, S. Onodera, 2018, International immunopharmacology.

Design and synthesis of novel nitrogen mustard-evodiamine hybrids with selective antiproliferative activity.

Fanxing Xu, Weiwei Liu, H. Hua, 2017, Bioorganic & medicinal chemistry letters.

Crosstalk of ROS/RNS and autophagy in silibinin-induced apoptosis of MCF-7 human breast cancer cells in vitro

T. Ikejima, S. Onodera, S. Tashiro, 2016, Acta Pharmacologica Sinica.

Silibinin alleviates ferroptosis of rat islet β cell INS-1 induced by the treatment with palmitic acid and high glucose through enhancing PINK1/parkin-mediated mitophagy.

T. Ikejima, Toshihiko Hayashi, K. Mizuno, 2023, Archives of biochemistry and biophysics.

Estrogen Receptors Are Involved in the Neuroprotective Effect of Silibinin in Aβ1–42-Treated Rats

T. Ikejima, Xiaoyu Song, S. Tashiro, 2018, Neurochemical Research.

Silibinin ameliorates STING-mediated neuroinflammation via downregulation of ferroptotic damage in a sporadic Alzheimer's disease model.

T. Ikejima, Toshihiko Hayashi, K. Mizuno, 2023, Archives of biochemistry and biophysics.

Nitric oxide induces apoptosis and autophagy; autophagy down-regulates NO synthesis in physalin A-treated A375-S2 human melanoma cells.

T. Ikejima, S. Onodera, S. Tashiro, 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Silibinin ameliorates amylin-induced pancreatic β-cell apoptosis partly via upregulation of GLP-1R/PKA pathway

T. Ikejima, S. Onodera, S. Tashiro, 2018, Molecular and Cellular Biochemistry.

Collagen I protects human keratinocytes HaCaT against UVB injury via restoring PINK1/parkin-mediated mitophagy.

T. Ikejima, Toshihiko Hayashi, S. Hattori, 2024, Archives of biochemistry and biophysics.

Gelatin but not type I collagen promotes bacteria phagocytosis in PMA-treated U937 human lymphoma cells

S. Hattori, H. Fujisaki, Wei-wei Liu, 2024, Connective tissue research.

Silibinin ameliorates anxiety/depression-like behaviors in amyloid β-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus

T. Ikejima, Xiaoyu Song, S. Tashiro, 2017, Physiology & Behavior.

Enhanced migration of murine fibroblast-like 3T3-L1 preadipocytes on type I collagen-coated dish is reversed by silibinin treatment

M. Yamato, T. Ikejima, S. Onodera, 2017, Molecular and Cellular Biochemistry.

Inhibition of YAP/TAZ pathway contributes to the cytotoxicity of silibinin in MCF-7 and MDA-MB-231 human breast cancer cells.

Toshihiko Hayashi, S. Hattori, H. Fujisaki, 2024, Cellular signalling.

The preparation of Cistanche phenylethanoid glycosides liquid proliposomes: Optimized formulation, characterization and proliposome dripping pills in vitro and in vivo evaluation.

M. Li, Jing Han, Yunjing Li, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.