R. C. Isaacs

发表

A straightforward route to functionalized intermediates containing the CD substructure of taxol.

W. Bornmann, S. Danishefsky, T. Magee, 1992 .

The development of novel noncovalent thrombin inhibitors

T. Tucker, R. C. Isaacs, 1999 .

C6 modification of the pyridinone core of thrombin inhibitor L-374,087 as a means of enhancing its oral absorption.

J. Vacca, S. Gardell, S. D. Lewis, 1998, Bioorganic & Medicinal Chemistry Letters.

Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. Implementation of P3 pyridine N-oxides to deliver an orally bioavailable series containing P1 N-benzylamides.

Youwei Yan, L. Kuo, J. Vacca, 2003, Bioorganic & medicinal chemistry letters.

Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 2: N-acetamidoimidazoles.

Lawrence C Kuo, Daniel R McMasters, Youwei Yan, 2008, Bioorganic & medicinal chemistry letters.

Design, synthesis and SAR of a series of 1,3,5-trisubstituted benzenes as thrombin inhibitors.

S. D. Lewis, E. A. Lyle, J. Lynch, 2011, Bioorganic & medicinal chemistry letters.

Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 1: Weakly basic azoles.

S. D. Lewis, B. J. Lucas, A. Naylor-Olsen, 2006, Bioorganic & Medicinal Chemistry Letters.

Cine substitution in vinylstannane cross-coupling reactions

G. Stork, R. C. Isaacs, 1990 .

Synthesis of an enantiomerically pure intermediate containing the CD substructure of taxol

S. Danishefsky, M. Grandi, R. C. Isaacs, 1993 .

The Total Synthesis of a Natural Cardenolide: (+)-Digitoxigenin

F. West, S. Manabe, Hee‐Yoon Lee, 1996 .

P3 optimization of functional potency, in vivo efficacy and oral bioavailability in 3-aminopyrazinone thrombin inhibitors bearing non-charged groups at the P1 position.

B. Wong, S. D. Lewis, E. A. Lyle, 2011, Bioorganic & medicinal chemistry letters.

Degradative routes to electrophilic CD-substructures of taxol

C. Coburn, S. Danishefsky, M. Grandi, 1993 .

Degradative Routes to Electrophilic CD-Substructures of Taxol.

C. Coburn, S. Danishefsky, M. Grandi, 2010 .

Aromatic P1 replacements for the highly potent HIV-1 protease inhibitor CRIXIVAN®

J. Huff, C. Coburn, J. Vacca, 1996 .

Synthesis of an Enantiomerically Pure Intermediate Containing the CD Substructure of Taxol.

S. Danishefsky, M. Grandi, R. C. Isaacs, 1993 .