J. M. Fernández

发表

A β-Cyclodextrin-Based Nanoparticle with Very High Transfection Efficiency Unveils siRNA-Activated TLR3 Responses in Human Prostate Cancer Cells

D. Manzanares, Pablo Játiva, C. O. Mellet, 2022, Pharmaceutics.

Unprecedented inhibition of glycosidase-catalyzed substrate hydrolysis by nanodiamond-grafted O-glycosides

R. Boukherroub, S. Szunerits, C. O. Mellet, 2015 .

Synthesis of (1 → 6)-carbodiimide-tethered pseudooligosaccharides via aza-Wittig reaction

J. Kovács, I. Pintér, J. Fuentes, 1997 .

Aza-Wittig reaction of sugar isothiocyanates and sugar iminophosphoranes: An easy entry to unsymmetrical sugar carbodiimides

J. Kovács, I. Pintér, J. Fuentes, 1997 .

Synthesis and glycosidase inhibitory activity of isourea-type bicyclic sp2-iminosugars related to galactonojirimycin and allonojirimycin

C. Ortiz Mellet, J. G. García Fernández, C. O. Mellet, 2012 .

The Synthesis and Structure of Linear and Dendritic Thiourea‐Linked Glycooligomers

C. O. Mellet, J. M. Fernandez, J. J. Blanco, 2006 .

Thermodynamics of the Dimer Formation of 2I,3I-O-(o-Xylylene)-per-O-Me-γ-cyclodextrin: Fluorescence, Molecular Mechanics and Molecular Dynamics

F. Mendicuti, J. Vicente, M. J. González-Álvarez, 2009, Journal of Fluorescence.

Syntheses of β-iodourea derivatives of carbohydrates and glycosylamino-oxazolines

J. F. Mota, C. O. Mellet, J. M. Fernandez, 1992 .

Syntheses and spectral properties of β-iodoureas and 2-amino-4,4-diphenyl-2-oxazolines

J. F. Mota, M. A. P. Adrian, J. M. Fernández, 1991 .

Chemistry and developments of N-thiocarbonyl carbohydrate derivatives: Sugar isothiocyanates, thioamides, thioureas, thiocarbamates, and their conjugates

C. O. Mellet, J. M. Fernandez, J. M. Fernández, 2000 .

Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease

K. Higaki, E. Nanba, R. Pieters, 2018, Molecules.

Tn Antigen Mimics Based on sp(2)-Iminosugars with Affinity for an anti-MUC1 Antibody.

G. Jiménez‐Osés, G. Bernardes, C. D. Navo, 2016, Organic letters.

Synthesis and Comparative Glycosidase Inhibitory Properties of Reducing Castanospermine Analogues

C. Ortiz Mellet, J. G. García Fernández, M. I. García-Moreno, 2005 .

Synthesis and anomeric stability of (1→6)-thiourea-linked pseudooligosaccharides

J. M. Benito, J. Defaye, T. Lindhorst, 1999 .

Synthesis, conformational flexibility and preliminary complexation behaviour of α,α′-trehalose-based macrocycles containing thiourea spacers

J. J. Blanco, J. Fuentes, J. M. Fernández, 1995 .

Competitive processes of a chromophore modified α-cyclodextrin in the presence of a fluorescence polarity sensitive probe

F. Mendicuti, N. Mayordomo, M. J. González-Álvarez, 2013 .

Stereoselective Synthesis of Difructose Dianhydrides by Use of the Xylylene Group as Stereodirecting Element in Spiroketalisation Reactions

Alejandro Méndez‐Ardoy, J. J. Blanco, E. Suárez-Pereira, 2011 .

Sugar Thioureas as Anion Receptors. Effect of Intramolecular Hydrogen Bonding in the Carboxylate Binding Properties of Symmetric Sugar Thioureas

J. M. Benito, J. J. Blanco, J. M. Fernández, 1999 .

Syntheses of partially protected d-galactopyranosylthioureas: New d-galactopyranosylimidazoline-2-thiones and d-galactopyranosylaminothiazoles

J. F. Mota, C. O. Mellet, J. M. Fernandez, 1989 .

Syntheses of d-ribosylamines, d-ribopyranosyl isothiocyanates, and d-ribopyranosylthioureas, and their transformations into heterocyclic compounds☆

J. F. Mota, C. O. Mellet, J. M. Fernandez, 1988 .

Synthesis of glycosylaminothiazoles

J. F. Mota, M. A. P. Adrian, J. M. Fernández, 1986 .

Copper(II)-complex directed regioselective mono-p-toluenesulfonylation of cyclomaltoheptaose at a primary hydroxyl group position: an NMR and molecular dynamics-aided design.

J. M. Benito, J. Defaye, L. Jicsinszky, 2011, The journal of physical chemistry. B.

Antileishmanial activity of sp2-iminosugar derivatives

S. Castanys, F. Gamarro, C. O. Mellet, 2015 .

Cyclodextrin Chemistry via Selective Protecting Group Manipulations

J. M. Benito, J. M. Fernández, 2018, Protecting Groups.

Thioureido-β-cyclodextrins as molecular carriers

C. O. Mellet, J. M. Fernandez, J. Defaye, 1996 .

Self-association of a naphthalene-capped-β-cyclodextrin through cooperative strong hydrophobic interactions

J. M. Benito, F. Mendicuti, Alejandro Méndez‐Ardoy, 2011 .

Molecular nanoparticle-based gene delivery systems

J. M. Benito, J. J. Blanco, J. M. Fernández, 2017 .

Difructose dianhydrides as synthetic intermediates. A synthesis of 3,6-anhydro--D-fructose

J. Defaye, J. M. Fernández, 1994 .

Multiply–linked cyclodextrin–aromatic hybrids: Caps, hinges and clips

J. M. Benito, C. Ortiz Mellet, J. M. Fernandez, 2019, Journal of Carbohydrate Chemistry.

Synthesis, structure, and inclusion capabilities of trehalose-based cyclodextrin analogues (cyclotrehalans).

E. Álvarez, J. M. Benito, C. O. Mellet, 2008, The Journal of organic chemistry.

The Reactivity of 1-O-α-D-glucopyranosyl-D-fructose (trehalulose) in pyridinium poly(hydrogen fluoride) or anhydrous HF. New D-glucose D-fructose mixed dianhydrides☆

J. Defaye, J. M. Fernández, 1992 .

New Castanospermine Glycoside Analogues Inhibit Breast Cancer Cell Proliferation and Induce Apoptosis without Affecting Normal Cells

J. M. Fernandez, H. Ouadid‐Ahidouch, C. Ortiz-Mellet, 2013, PloS one.

sp2-Iminosugars as chemical mimics for glycodrug design

J. G. García Fernández, C. O. Mellet, J. M. Fernandez, 2020 .

Bicyclic (galacto)nojirimycin analogues as glycosidase inhibitors: effect of structural modifications in their pharmacological chaperone potential towards β-glucocerebrosidase.

A. Llebaria, A. Trapero, Meritxell Egido-Gabás, 2011, Organic & biomolecular chemistry.

Synthesis and biological evaluation of 6-oxa-nor-tropane glycomimetics as glycosidase inhibitors

C. O. Mellet, J. M. Fernandez, M. I. García-Moreno, 2007 .

Castanospermine-Trehazolin Hybrids: A New Family of Glycomimetics with Tunable Glycosidase Inhibitory Properties.

M. I. García-Moreno, Paula Díaz-Pérez, J. M. Fernández, 2002 .

Polyhydroxylated N-(thio)carbamoyl piperidines: nojirimycin-type glycomimetics with controlled anomeric configuration

M. I. García-Moreno, J. M. Fernández, C. Mellet, 1999 .

sp2‐Iminosugar α‐glucosidase inhibitor 1‐C‐octyl‐2‐oxa‐3‐oxocastanospermine specifically affected breast cancer cell migration through Stim1, β1‐integrin, and FAK signaling pathways

H. Ouadid‐Ahidouch, C. Ortiz-Mellet, A. Ahidouch, 2017, Journal of cellular physiology.

N-THIOCARBONYL AZASUGARS : A NEW FAMILY OF CARBOHYDRATE MIMICS WITH CONTROLLED ANOMERIC CONFIGURATION

F. Cañada, J. J. Blanco, J. C. Arribas, 1997 .

1,2,3-Triazoles and related glycoconjugates as new glycosidase inhibitors

C. O. Mellet, J. M. Fernandez, R. Duval, 2005 .

Inhibitors and effectors of the glycosidases as therapeutic tools

J. M. Fernández, C. Mellet, 2017 .

Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease

C. Ortiz Mellet, J. M. Fernandez, M. Cordero, 2015, Scientific Reports.

Synthesis of Glycosyl(thio)ureido Sugars via Carbodiimides and Their Conformational Behavior in Water.

J. Fuentes, V. M. D. Pérez, J. M. Fernández, 2000 .

Cyclodextrin-Scaffolded Glycoclusters

H. Caro, J. M. Benito, J. Defaye, 1998 .

O-Acetyl Protection of 6-Aminoaldopyranosides and 1-Aminoalditols

C. O. Mellet, J. M. Fernandez, J. Fuentes, 1995 .

Influence of intramolecular hydrogen-bonding on the conformational properties of sugar thioureas

J. J. Blanco, J. Fuentes, J. M. Fernández, 1994 .

Building Blocks for Glycopeptide Synthesis. Disaccharide Glycosyl Isothiocyanates

C. O. Mellet, J. M. Fernandez, J. J. Blanco, 1993 .

Chiral 2-thioxotetrahydro-1,3-O,N-heterocycles from carbohydrates. 2. Stereocontrolled synthesis of oxazolidine pseudo-C-nucleosides and bicyclic oxazine-2-thiones

J. Fuentes, J. M. Fernández, C. Mellet, 1993 .

Nitrogen versus sulfur acylation in sugar thioureas: regioselectivity and conformational consequences

J. M. Benito, M. I. García-Moreno, J. M. Fernández, 2000 .

Tautomeric rearrangement of 3-deoxy-3-thioureidoaldoses: a novel synthetic route to carbohydrate mimics having a cyclic thiourea structure

J. J. Blanco, J. Fuentes, J. M. Fernández, 1996 .

Enantiopure 2-Thioxotetrahydro-1,3-O,N-heterocycles from Carbohydrates. 3. Enantiopure C-4 Chiral Oxazine- and Oxazolidine-2-thiones from 3-Deoxy-3-isothiocyanato Sugars

J. J. Blanco, J. Fuentes, J. M. Fernández, 1994 .

Synthesis and conformational properties of sugar amides and thioamides

J. Fuentes, J. M. Fernández, C. Mellet, 1994 .

1-Doexy-1-isothiocyanato-d-fructose as intermediate in syntheses of 1,3-O(S),N-heterocycles

J. F. Mota, C. O. Mellet, J. M. Fernandez, 1994 .

Comparative studies on lectin-carbohydrate interactions in low and high density homo- and heteroglycoclusters.

J. M. Benito, C. O. Mellet, J. M. Fernandez, 2010, Organic & biomolecular chemistry.

Glyconanocavities: Cyclodextrins and Beyond

C. O. Mellet, J. M. Fernandez, J. Defaye, 2006 .

Chiral 2-thioxotetrahydro-1,3-O,N-heterocycles from carbohydrates

J. Fuentes, J. M. Fernández, C. Mellet, 1992 .

Synthesis of Calystegine B2, B3, and B4 Analogues: Mapping the Structure‐Glycosidase Inhibitory Activity Relationships in the 1‐Deoxy‐6‐oxacalystegine Series

M. I. García-Moreno, J. M. Fernández, C. Mellet, 2004 .

Multivalency in heterogeneous glycoenvironments: hetero-glycoclusters, -glycopolymers and -glycoassemblies

C. O. Mellet, J. M. Fernandez, J. J. Blanco, 2013 .

Synthesis of 6,7‐Dideoxy‐7‐isothiocyanatoheptoses: Stable Fully Unprotected Monosaccharide Isothiocyanates.

J. M. Benito, J. M. Fernández, C. Mellet, 2000 .

Chiral 2‐Thioxotetrahydro‐1,3‐O,N‐heterocycles from Carbohydrates.

J. Fuentes, J. M. Fernández, C. Mellet, 1992 .

Regioselective benzoylations of glycopyranosylamines: Synthesis of partially protected glycopyranosyl isothiocyanates

J. F. Mota, C. O. Mellet, J. M. Fernandez, 1989 .

Fast and solvent free polymerization of carbohydrates induced by non-thermal atmospheric plasma

François Jérôme, Abdellatif Barakat, A. Barakat, 2016 .

Chemical and Enzymatic Approaches to Carbohydrate-Derived Spiroketals: Di-d-Fructose Dianhydrides (DFAs)

J. M. Benito, M. I. García-Moreno, J. M. Fernández, 2008, Molecules.

Efficient use of Ellman safety-catch linker for solid-phase assisted synthesis of multivalent glycoconjugates.

J. M. Benito, J. M. Fernández, C. Mellet, 2007, Journal of combinatorial chemistry.

Cell uptake mechanisms of glycosylated cationic pDNA–cyclodextrin nanoparticles

C. O. Mellet, A. Díaz‐Moscoso, C. D. Giorgio, 2015 .

Glycomimetic-Based Pharmacological Chaperones for Lysosomal Storage Disorders: Lessons from Gaucher, GM1-Gangliosidosis and Fabry Diseases

E. Sánchez-Fernández, J. M. Fernández, C. Mellet, 2016 .

A Practical Amine-Free Synthesis of Symmetric Ureas and Thioureas by Self-Condensation of Iso(thio)cyanates

F. Santoyo-González, J. M. Benito, J. J. Blanco, 1999 .

Carbohydrate-derived spiroketals: stereoselective synthesis of di-d-fructose dianhydrides

J. M. Benito, M. Gómez-García, J. M. Fernández, 2004 .

Efficient transfection of hepatocytes mediated by mRNA complexed to galactosylated cyclodextrins.

S. D. De Smedt, K. Remaut, Alejandro Méndez‐Ardoy, 2012, Bioconjugate chemistry.

Supplementary information

Eduardo Sontag, R. Stocker, Steven Smriga, 2015, Acta Pharmacologica Sinica.

Design and synthesis of a "click" high-mannose oligosaccharide mimic emulating Man8 binding affinity towards Con A.

Alejandro Méndez‐Ardoy, J. M. Fernandez, V. Moreau, 2012, Chemical communications.

Insights in cellular uptake mechanisms of pDNA-polycationic amphiphilic cyclodextrin nanoparticles (CDplexes).

D. Vercauteren, J. M. Benito, C. Ortiz Mellet, 2010, Journal of controlled release : official journal of the Controlled Release Society.

A Practical Amine-Free Synthesis of Symmetric Ureas and Thioureas by Self-Condensation of Iso(thio)cyanates.

F. Santoyo-González, J. M. Benito, J. J. Blanco, 2000 .

Harmonized tuning of nucleic acid and lectin binding properties with multivalent cyclodextrins for macrophage-selective gene delivery

J. M. Benito, C. O. Mellet, Alejandro Méndez‐Ardoy, 2015 .

Click Multivalent Glycomaterials: Glycoclusters, Glycodendrimers, Glycopolymers, Hybrid Glycomaterials, and Glycosurfaces

C. O. Mellet, Alejandro Méndez‐Ardoy, J. M. Fernandez, 2013 .

Sulfur Atom Participation in Thiooligosaccharide Chemistry: Synthesis of 1‘-Thiotrehalulose and 1‘-epi-Thiotrehalulose and Comparative Reactivity with the O-Linked Disaccharide Analogue, Trehalulose†

J. Defaye, André Mellet, J. M. Fernández, 1998 .

Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery.

J. M. Benito, C. Di Giorgio, C. O. Mellet, 2011, Biomaterials.

Deciphering of polycationic carbohydrate based non-viral gene delivery agents by ESI-LTQ-Orbitrap using CID/HCD pairwise tandem mass spectrometry

J. M. Benito, C. Przybylski, V. Bonnet, 2016 .

Cyclodextrin-Based Gene Delivery Systems

J. M. Benito, J. M. Fernández, C. Mellet, 2011 .

Stereoselective synthesis of nonsymmetrical difructose dianhydrides from xylylene-tethered d-fructose precursors

P. Balbuena, M. I. García-Moreno, J. M. Fernández, 2008 .

Cyclodextrin-scaffolded amphiphilic aminoglucoside clusters: self-assembling and gene delivery capabilities

J. M. Benito, C. D. Giorgio, P. Vierling, 2014 .

Synthesis of N-, S-, and C-Glycoside Castanospermine Analogues with Selective Neutral α-Glucosidase Inhibitory Activity as Antitumor Agents.

H. Ouadid‐Ahidouch, A. Ahidouch, E. Sánchez-Fernández, 2010 .

Multi-mannosides based on a carbohydrate scaffold: synthesis, force field development, molecular dynamics studies, and binding affinities for lectin Con A.

C. O. Mellet, J. M. Fernandez, J. Kovensky, 2007, The Journal of organic chemistry.

Novel reactions of benzyne with acetylenic ethers

H. Wasserman, J. M. Fernández, 1968 .

Study of the conformational and self-aggregation properties of 2I,3I-O-(o-xylylene)-per-O-Me-alpha- and -beta-cyclodextrins by fluorescence and molecular modeling.

F. Mendicuti, P. Balbuena, M. J. González-Álvarez, 2008, The journal of physical chemistry. B.

The Thiocarbonyl Group in Carbohydrate Chemistry

C. O. Mellet, J. M. Fernandez, J. M. Fernández, 1996 .

Synthesis and comparative lectin-binding affinity of mannosyl-coated β-cyclodextrin-dendrimer constructs

J. M. Benito, J. Defaye, H. Law, 2000 .

Synthesis and Comparative Lectin‐Binding Affinity of Mannosyl‐Coated β‐Cyclodextrin‐Dendrimer Constructs.

J. M. Benito, J. Defaye, H. Law, 2000 .

Castanospermine-trehazolin hybrids: a new family of glycomimetics with tuneable glycosidase inhibitory properties.

C. Ortiz Mellet, J. G. García Fernández, M. I. García-Moreno, 2002, Chemical communications.

Mannosyl-coated nanocomplexes from amphiphilic cyclodextrins and pDNA for site-specific gene delivery.

J. M. Benito, C. Di Giorgio, Alejandro Méndez‐Ardoy, 2011, Biomaterials.

Synthesis of glycosyl(thio)ureido sugars via carbodiimides and their conformational behaviour in water.

C. Ortiz Mellet, J. G. García Fernández, V. M. Díaz Pérez, 2000, Carbohydrate research.

PREBIOTIC DI-D-FRUCTOSE DIANHYDRIDE-ENRICHED CARAMELS: DEVELOPMENT OF BATCH PROCESS (1 L) AND OPTIMIZATION OF OPERATING CONDITIONS

Jean-Louis Havet, C. Porte, J. M. Fernández, 2013 .

PREBIOTIC DID-FRUCTOSE DIANHYDRIDE-ENRICHED CARAMELS : DEVELOPMENT OF BATCH PROCESS ( 1 L ) AND OPTIMIZATION OF OPERATING CONDITIONSjfpe

Jean-Louis Havet, C. Porte, J. M. Fernández, 2011 .

The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study.

C. Ortiz Mellet, J. G. García Fernández, F. Ortega-Caballero, 2017, Chemistry.

Tn Antigen Mimics Based on sp(2)-Iminosugars with Affinity for an anti-MUC1 Antibody.

G. Bernardes, F. Corzana, V. J. Somovilla, 2016, Organic letters.

Aerosolized Non-viral Nucleic Acid Delivery in the Vaginal Tract of Pigs

D. Vanrompay, Carlos Segovia Fernández, J. M. Benito, 2015, Pharmaceutical Research.

Insights in cellular uptake mechanisms of pDNA-polycationic amphiphilic cyclodextrin nanoparticles (CDplexes).

D. Vercauteren, J. M. Benito, C. Ortiz Mellet, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids

F. Gamarro, C. Ortiz Mellet, J. G. García Fernández, 2019, Molecules.