P. Barnes

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I k B a Degradation and Nuclear Factor- k B DNA Binding Are Insufficient for Interleukin-1 b and Tumor Necrosis Factor- a -induced k B-dependent Transcription* REQUIREMENT FOR AN ADDITIONAL ACTIVATION PATHWAY

M. Lindsay, M. Bergmann, L. Hart, 1998 .

Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial

D. V. Nicolau, S. de Lusignan, P. Barnes, 2021, The Lancet.

Bronchial epithelial cells: The key effector cells in the pathogenesis of chronic obstructive pulmonary disease?

X. Yao, Mao Huang, Wei Gao, 2015, Respirology.

Discovery of BRL 50481, a Selective Inhibitor of Phosphodiesterase 7: In vitro Studies in Human Monocytes, Lung Macrophages and CD8 + T-Lymphocytes

A. Nicholson, L. Donnelly, Susan J. Smith, 2004 .

Pathophysiology of allergic inflammation

P. Barnes, P. Barnes, 2011, Immunological reviews.

Hepcidin is essential for alveolar macrophage function and is disrupted by smoke in a murine COPD model

Cloonan, J. Scandura, S. Vaulont, 2021 .

Autophagy in asthma and chronic obstructive pulmonary disease

L. Donnelly, J. Baker, Peter J Barnes, 2022, Clinical science.

Cigarette smoke-induced impairment of autophagy in macrophages increases galectin-8 and inflammation

S. Abe, M. To, Kazuhiro Ito, 2021, Scientific Reports.

Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis

B. Stripp, L. de Leval, G. Blandino, 2022, European Respiratory Journal.

Inhaled corticosteroids for the treatment of COVID-19

T. Welte, M. Bafadhel, R. Faner, 2022, European Respiratory Review.

Targeting cytokines to treat asthma and chronic obstructive pulmonary disease

P. Barnes, P. Barnes, 2018, Nature Reviews Immunology.

Attenuation of tachykinin‐induced airflow obstruction and microvascular leakage in immature airways

K. Tokuyama, H. Mochizuki, A. Morikawa, 1993, British journal of pharmacology.

TGF- b Signaling Pathways in Different Compartments of the Lower Airways of Patients With Stable COPD

K. Chung, P. Brun, B. Balbi, 2018 .

Will it be steroids for ever?

P. Barnes, P. Barnes, 2005, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Importin‐7 mediates glucocorticoid receptor nuclear import and is impaired by oxidative stress, leading to glucocorticoid insensitivity

O. Usmani, A. Hakim, I. Adcock, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary

I. Pavord, J. Wedzicha, A. Anzueto, 2023, Respirology.

Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NF‐κB‐independent mechanism

M. Belvisi, L. Donnelly, M. Birrell, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics

M. Currie, S. Kharitonov, L. Donnelly, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Rescue treatment in asthma. More than as-needed bronchodilation.

I. Adcock, P. Barnes, A. Papi, 2009, Chest.

Increased inflammatory markers in the exhaled breath condensate of cigarette smokers

P. Barnes, O. Resta, M. Foschino-Barbaro, 2003, European Respiratory Journal.

The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease

D. Mannino, G. Koppelman, B. Lipworth, 2021, The Lancet Respiratory Medicine.

Isorhapontigenin, a bioavailable dietary polyphenol, suppresses airway epithelial cell inflammation through a corticosteroid‐independent mechanism

P. Barnes, L. Donnelly, P. Fenwick, 2017, British journal of pharmacology.

The Asthma Control Questionnaire as a clinical trial endpoint: past experience and recommendations for future use

R. Dahl, I. Pavord, M. Wechsler, 2014, Allergy. European Journal of Allergy and Clinical Immunology.

Increased neutrophils and cytokines, TNF-α and IL-8, in induced sputum of non-asthmatic patients with chronic dry cough

K. Chung, U. Lalloo, P. Barnes, 1999, Thorax.

COPD_A_339889 273..282

C. Jenkins, N. Zhong, B. Celli, 2022 .

Increased CCL5 and CXCL7 chemokine expression is associated with neutrophil activation in severe stable COPD

Cesare, K. Chung, P. Brun, 2009 .

NF-κB involvement in IL-1β-induction of GM-CSF and COX-2: inhibition by glucocorticoids does not require I-κB

I. Adcock, P. Barnes, R. Newton, 1997 .

Alveolar type II cells harbouring SARS-CoV-2 show senescence with a proinflammatory phenotype

L. de Leval, V. Gorgoulis, C. Kittas, 2021, Airway cell biology and immunopathology.

Inhaled corticosteroids reduce senescence in endothelial progenitor cells from patients with COPD

J. Wedzicha, G. Donaldson, V. Gorgoulis, 2022, Thorax.

Single cell quantification of microRNA from small numbers of non-invasively sampled primary human cells

K. Willison, D. Klug, L. Donnelly, 2023, Communications biology.

Increase in vascular permeability produced in rat airways by PAF: potentiation by adrenalectomy

L. Fabbri, P. Boschetto, M. Boscaro, 1992, British journal of pharmacology.

MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients

L. Fabbri, I. Adcock, K. Chung, 2009, Histopathology.

NF- B and Activator Protein 1 Response Elements and the Role of Histone Modifications in IL-1 -Induced TGF- 1 Gene Transcription

Kazuhiro Ito, Kang-Yun Lee, I. Adcock, 2005 .

Decreased histone deacetylase activity in chronic obstructive pulmonary disease.

I. Adcock, P. Barnes, W. M. Elliott, 2005, The New England journal of medicine.

Chronic obstructive pulmonary disease • 12: New treatments for COPD

P. Barnes, P J Barnes, P. Barnes, 2003, Thorax.

Defective macrophage phagocytosis of bacteria in COPD

J. Wedzicha, P. Barnes, L. Donnelly, 2009, European Respiratory Journal.

Inhaled Corticosteroids.

P. Barnes, 2010, Pharmaceuticals.

Comparison of fluticasone propionate and budesonide on COPD macrophage and neutrophil function

P. Barnes, L. Donnelly, K. Belchamber, 2018, International journal of chronic obstructive pulmonary disease.

Activation and localization of transcription factor, nuclear factor-kappaB, in asthma.

I. Adcock, K. Chung, P. Barnes, 1998, American journal of respiratory and critical care medicine.

Steroid resistance in asthma.

I. Adcock, P. Barnes, I. Adcock, 1995, QJM : monthly journal of the Association of Physicians.

Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease.

I. Adcock, P. Barnes, W. M. Elliott, 2010, American journal of respiratory and critical care medicine.

Oxidative/nitrosative stress selectively altered A2B adenosine receptors in chronic obstructive pulmonary disease

M. Triggiani, I. Adcock, K. Chung, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Positional cloning of a novel gene influencing asthma from Chromosome 2q14

Gonçalo Abecasis, John Broxholme, Chris P Ponting, 2003, Nature Genetics.

Glottal Aperture and Buccal Airflow Leaks Critically Affect Forced Oscillometry Measurements.

N. Pride, I. Horváth, O. Usmani, 2015, Chest.

Chronic obstructive pulmonary disease: molecular and cellularmechanisms

R. Pauwels, S. Shapiro, P. Barnes, 2003, European Respiratory Journal.

Phosphodiesterase expression in human epithelial cells.

I. Adcock, J. Seybold, A. Robichaud, 1998, The American journal of physiology.

Granulocyte activation markers in induced sputum: comparison between chronic obstructive pulmonary disease, asthma, and normal subjects.

P. Barnes, V. Keatings, P. Barnes, 1997, American journal of respiratory and critical care medicine.

Association of increased CCL5 and CXCL7 chemokine expression with neutrophil activation in severe stable COPD

I. Adcock, K. Chung, P. Brun, 2009, Thorax.

STAT4 activation in smokers and patients with chronic obstructive pulmonary disease

I. Adcock, K. Chung, C. Donner, 2004, European Respiratory Journal.

Increased expression of nuclear factor-κB in bronchial biopsies from smokers and patients with COPD

I. Adcock, T. Oates, F. Ioli, 2002, European Respiratory Journal.

Decreased T lymphocyte infiltration in bronchial biopsies of subjects with severe chronic obstructive pulmonary disease

I. Adcock, K. Chung, P. Brun, 2001, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Inhaled Corticosteroids.

P. Barnes, 2010, Pharmaceuticals.

Effect of inhaled endotoxin on induced sputum in normal, atopic, and atopic asthmatic subjects

K. Chung, P. Barnes, J. Nightingale, 1998, Thorax.

Matrix metalloproteinase-9 expression in asthma: effect of asthma severity, allergen challenge, and inhaled corticosteroids.

K. Chung, P. Barnes, A. Jatakanon, 2002, Chest.

Expression and activity of histone deacetylases in human asthmatic airways.

I. Adcock, K. Chung, P. Barnes, 2002, American journal of respiratory and critical care medicine.

Elevated expression of endothelin-1 and endothelin-converting enzyme-1 in idiopathic pulmonary fibrosis: possible involvement of proinflammatory cytokines.

B. Corrin, M. Tsao, M. Yanagisawa, 1997, American journal of respiratory cell and molecular biology.

Differential IkappaB kinase activation and IkappaBalpha degradation by interleukin-1beta and tumor necrosis factor-alpha in human U937 monocytic cells. Evidence for additional regulatory steps in kappaB-dependent transcription.

Y. Nasuhara, I. Adcock, P. Barnes, 1999, The Journal of biological chemistry.

Increased p21(CIP1/WAF1) and B cell lymphoma leukemia-x(L) expression and reduced apoptosis in alveolar macrophages from smokers.

I. Adcock, K. Chung, P. Barnes, 2002, American journal of respiratory and critical care medicine.

Delayed eosinophil apoptosis in asthma.

M. Lindsay, P. Barnes, M. Giembycz, 2000, The Journal of allergy and clinical immunology.

Validation of IKKβ as therapeutic target in airway inflammatory disease by adenoviral‐mediated delivery of dominant‐negative IKKβ to pulmonary epithelial cells

P. Barnes, J. Chivers, N. Holden, 2005 .

Mitogen-activated protein kinase modulation of nuclear factor-kappaB-induced granulocyte macrophage-colony-stimulating factor release from human alveolar macrophages.

I. Adcock, Kazuhiro Ito, Sam Lim, 2004, American journal of respiratory cell and molecular biology.

Exhaled carbon monoxide and nitric oxide in COPD.

P. Montuschi, P. Barnes, S. Kharitonov, 2001, Chest.

Epigenetics and airways disease

I. Adcock, P. Barnes, Kazuhiro Ito, 2006, Respiratory Research.

Airway hyperresponsiveness, elevation of serum-specific IgE and activation of T cells following allergen exposure in sensitized Brown-Norway rats.

K. Chung, P. Barnes, A. Kay, 1995, Immunology.

Induction of macrophage inflammatory protein 2 gene expression by interleukin 1 beta in rat lung.

I. Adcock, K. Chung, P. Barnes, 1995, Thorax.

Inhaled Corticosteroids

P. Barnes, P. Barnes, 2010, Pharmaceuticals.

Air pollution and COPD: GOLD 2023 committee report

I. Pavord, J. Wedzicha, A. Anzueto, 2023, European Respiratory Journal.

Epigenetics and airways disease

Kazuhiro Ito, P. Ford, I. Adcock, 2006, Respiratory research.

Nuclear localisation of p65 in sputum macrophages but not in sputum neutrophils during COPD exacerbations.

L. Fabbri, I. Adcock, K. Chung, 2003, Thorax.

Alternate COX-2 transcripts are differentially regulated: implications for post-transcriptional control.

P. Barnes, R. Newton, J. Seybold, 1997, Biochemical and biophysical research communications.

Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells

P. Barnes, L. Donnelly, Kazuhiro Ito, 2016, Scientific Reports.

Bronchial epithelial cells: The key effector cells in the pathogenesis of chronic obstructive pulmonary disease?

X. Yao, Mao Huang, Wei Gao, 2015, Respirology.

Different MAP-Kinase-Dependent Cytokine Responses in Cells of the Monocyte Lineage

A. Nicholson, R. Mayer, L. Donnelly, 2007 .

Importin‐7 mediates glucocorticoid receptor nuclear import and is impaired by oxidative stress, leading to glucocorticoid insensitivity

O. Usmani, A. Hakim, I. Adcock, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Intranasal administration of eotaxin increases nasal eosinophils and nitric oxide in patients with allergic rhinitis.

P. Barnes, S. Kharitonov, J. D. Antuni, 2000, The Journal of allergy and clinical immunology.

Phosphodiesterase expression in human epithelial cells.

J. Seybold, A. Robichaud, L. Wright, 1998, American journal of physiology. Lung cellular and molecular physiology.

Chronic obstructive pulmonary disease • 12: New treatments for COPD

P. Barnes, 2003, Thorax.

Increased tachykinin receptor gene expression in asthmatic lung and its modulation by steroids.

I. Adcock, P. Barnes, C. Brown, 1993, Journal of molecular endocrinology.

Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1alpha, granulocyte-macrophage colony-stimulating factor, and interferon-gamma release from alveolar macrophages in asthma.

K. Chung, P. Barnes, B. O'connor, 1998, American journal of respiratory and critical care medicine.

THE IMPACT OF DRUG CLEARANCE ON DURATION OF ACTION OF CORTICOSTEROIDS

O. Usmani, A. Hakim, I. Adcock, 2015 .

Repression of Inflammatory Gene Expression in Human Pulmonary Epithelial Cells by Small-Molecule I (cid:1) B Kinase Inhibitors □ S

D. Proud, R. Leigh, N. Holden, 2007 .

Association of increased CCL5 and CXCL7 chemokine expression with neutrophil activation in severe stable COPD

P. Brun, B. Balbi, C. Usai, 2009, Thorax.

Anti-Tumor Necrosis Factor for Supplementary Management in Severe Asthma: A Systematic Review and Meta-analysis.

R. H. Shueb, R. Mohamud, Y. Chan, 2023, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.