Arthur Christopoulos

发表

2001MotulskyChristopoulos Fitting Models to Biological Data

Harvey Motulsky, Arthur Christopoulos, 2015 .

Biomedical Applications of Computer Modeling

Arthur Christopoulos, 2000 .

Homology modeling of GPCRs.

Ruben Abagyan, Arthur Christopoulos, John Simms, 2009, Methods in molecular biology.

Improving virtual screening of G protein-coupled receptors via ligand-directed modeling

Arthur Christopoulos, John Simms, Denise Wootten, 2017, PLoS Comput. Biol..

Prediction of Loops in G Protein-Coupled Receptor Homology Models: Effect of Imprecise Surroundings and Constraints

Arthur Christopoulos, Santosh B. Noronha, Bhumika Arora, 2016, J. Chem. Inf. Model..

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Introduction and Other Protein Targets

Arthur Christopoulos, Christopher Southan, Jörg Striessnig, 2019, British journal of pharmacology.

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

Arthur Christopoulos, Christopher Southan, John A Peters, 2019, British journal of pharmacology.

Novel Allosteric Modulators of G Protein-coupled Receptors*

Arthur Christopoulos, Patrick M Sexton, P. Sexton, 2015, The Journal of Biological Chemistry.

Bridging the gap: bitopic ligands of G-protein-coupled receptors.

Arthur Christopoulos, Patrick M Sexton, P. Sexton, 2013, Trends in pharmacological sciences.

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties.

Jie Zhang, Harald Schwalbe, Francesco Luigi Gervasio, 2013, Cancer cell.

Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands*

Arthur Christopoulos, Patrick M Sexton, Michael W Parker, 2007, Journal of Biological Chemistry.

Molecular Determinants of Allosteric Modulation at the M1 Muscarinic Acetylcholine Receptor*

Arthur Christopoulos, Patrick M Sexton, Laura López, 2014, The Journal of Biological Chemistry.

Orthosteric and Allosteric Modes of Interaction of Novel Selective Agonists of the M1 Muscarinic Acetylcholine Receptor

Arthur Christopoulos, Patrick M. Sexton, Christopher J. Langmead, 2010, Molecular Pharmacology.

Towards tissue-specific pharmacology: insights from the calcium-sensing receptor as a paradigm for GPCR (patho)physiological bias.

Arthur Christopoulos, Patrick M Sexton, P. Sexton, 2015, Trends in pharmacological sciences.

International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology

Arthur Christopoulos, Richard R. Neubig, Terry Kenakin, 2003, Pharmacological Reviews.

Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.

Arthur Christopoulos, Radostin Danev, Cassandra Koole, 2020, ACS pharmacology & translational science.

Biased Agonism at G Protein‐Coupled Receptors: The Promise and the Challenges—A Medicinal Chemistry Perspective

Arthur Christopoulos, Ben Capuano, A. Christopoulos, 2014, Medicinal research reviews.

Structural basis of receptor sulfotyrosine recognition by a CC chemokine: the N-terminal region of CCR3 bound to CCL11/eotaxin-1.

Arthur Christopoulos, Meritxell Canals, A. Christopoulos, 2014, Structure.

Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor

J. Andrew McCammon, Arthur Christopoulos, Patrick M. Sexton, 2016, Proceedings of the National Academy of Sciences.

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

Arthur Christopoulos, Laurence J Miller, Patrick M Sexton, 2013, Proceedings of the National Academy of Sciences.

Signalling bias in new drug discovery: detection, quantification and therapeutic impact

Arthur Christopoulos, Terry Kenakin, T. Kenakin, 2012, Nature Reviews Drug Discovery.

To Bind or Not to Bind: Unravelling GPCR Polypharmacology

Arthur Christopoulos, Patrick M. Sexton, P. Sexton, 2018, Cell.

The Molecular Control of Calcitonin Receptor Signaling.

Arthur Christopoulos, Ming-Wei Wang, Erney Ramírez-Aportela, 2019, ACS pharmacology & translational science.

Allosteric modulation of G protein-coupled receptors.

Arthur Christopoulos, Patrick M Sexton, P. Sexton, 2007, Annual review of pharmacology and toxicology.

Allosteric targeting of receptor tyrosine kinases

Arthur Christopoulos, Frederik De Smet, Peter Carmeliet, 2014, Nature Biotechnology.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

Arthur Christopoulos, Christopher Southan, Stephen PH Alexander, 2017, British journal of pharmacology.

Structural insights into G-protein-coupled receptor allostery

Arthur Christopoulos, Patrick M. Sexton, Alisa Glukhova, 2018, Nature.

A Novel Mechanism of G Protein-coupled Receptor Functional Selectivity

Arthur Christopoulos, Nathan E Hall, Patrick M Sexton, 2008, Journal of Biological Chemistry.

Advances in G Protein-Coupled Receptor Allostery: From Function to Structure

Arthur Christopoulos, A. Christopoulos, 2014, Molecular Pharmacology.

Functional Importance of a Structurally Distinct Homodimeric Complex of the Family B G Protein-Coupled Secretin Receptor

Ruben Abagyan, Arthur Christopoulos, Laurence J Miller, 2009, Molecular Pharmacology.

A simple method for quantifying functional selectivity and agonist bias.

Arthur Christopoulos, Steven J Novick, Steven J. Novick, 2012, ACS chemical neuroscience.

4-Phenylpyridin-2-one Derivatives: A Novel Class of Positive Allosteric Modulator of the M1 Muscarinic Acetylcholine Receptor.

Arthur Christopoulos, Patrick M Sexton, Ben Capuano, 2016, Journal of Medicinal Chemistry.

Dominant Negative G Proteins Enhance Formation and Purification of Agonist-GPCR-G Protein Complexes for Structure Determination.

Arthur Christopoulos, Denise Wootten, Patrick M. Sexton, 2018, ACS pharmacology & translational science.

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

Arthur Christopoulos, P. Jeffrey Conn, Craig W. Lindsley, 2009, Nature Reviews Drug Discovery.

Identification of Orthosteric and Allosteric Site Mutations in M2 Muscarinic Acetylcholine Receptors That Contribute to Ligand-selective Signaling Bias*

Arthur Christopoulos, Nathan E Hall, Patrick M Sexton, 2010, The Journal of Biological Chemistry.

Muscarinic acetylcholine receptors: novel opportunities for drug development

Arthur Christopoulos, Brian K. Kobilka, Patrick M. Sexton, 2014, Nature Reviews Drug Discovery.

A kinetic view of GPCR allostery and biased agonism.

Arthur Christopoulos, Patrick M Sexton, Robert G Parton, 2017, Nature chemical biology.

Quantification of Ligand Bias for Clinically Relevant β2-Adrenergic Receptor Ligands: Implications for Drug Taxonomy

Arthur Christopoulos, Michel Bouvier, A. Christopoulos, 2014, Molecular Pharmacology.

Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor

Ruben Abagyan, Arthur Christopoulos, Irina Kufareva, 2016, Cell Research.

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Introduction and Other Protein Targets

Arthur Christopoulos, Adam J. Pawson, Michael Spedding, 2019, British Journal of Pharmacology.

Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity

Arthur Christopoulos, Patrick M. Sexton, Alisa Glukhova, 2017, Cell.

Structure-function studies of muscarinic acetylcholine receptors.

Arthur Christopoulos, Patrick M Sexton, John Simms, 2012, Handbook of experimental pharmacology.

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

Arthur Christopoulos, Brian K. Kobilka, Mark G. Bures, 2016, Nature.

Orthosteric/allosteric bitopic ligands: going hybrid at GPCRs.

Arthur Christopoulos, Patrick M Sexton, P. Sexton, 2009, Molecular interventions.

Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors

Davide Provasi, Arthur Christopoulos, Marta Filizola, 2016, ACS chemical biology.

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

Arthur Christopoulos, Jonathan A. Javitch, Bryan L. Roth, 2007, Journal of Pharmacology and Experimental Therapeutics.

Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes.

Arthur Christopoulos, Patrick M Sexton, P. Sexton, 2009, Journal of medicinal chemistry.

RNA editing of the serotonin 5HT2C receptor and its effects on cell signalling, pharmacology and brain function.

Arthur Christopoulos, Patrick M Sexton, P. Sexton, 2008, Pharmacology & therapeutics.

Mechanistic Insights into Allosteric Structure-Function Relationships at the M1 Muscarinic Acetylcholine Receptor*

Arthur Christopoulos, Laura López, Patrick M. Sexton, 2014, The Journal of Biological Chemistry.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein‐coupled receptors

Arthur Christopoulos, Christopher Southan, Stephen PH Alexander, 2017, British journal of pharmacology.

Functional and structural perspectives on allosteric modulation of GPCRs.

Arthur Christopoulos, Christopher J Langmead, C. Langmead, 2014, Current opinion in cell biology.

The role of kinetic context in apparent biased agonism at GPCRs

Arthur Christopoulos, Patrick M Sexton, Jonathan A Javitch, 2016, Nature Communications.

Structure of the adenosine-bound human adenosine A1 receptor–Gi complex

Arthur Christopoulos, Wolfgang Baumeister, Radostin Danev, 2018, Nature.

Emerging paradigms in GPCR allostery: implications for drug discovery

Arthur Christopoulos, Denise Wootten, Patrick M. Sexton, 2013, Nature Reviews Drug Discovery.

Phase-plate cryo-EM structure of a class B GPCR-G protein complex

Arthur Christopoulos, Wolfgang Baumeister, Georgios Skiniotis, 2017, Nature.

Endogenous Allosteric Modulators of G Protein–Coupled Receptors

Arthur Christopoulos, Patrick M Sexton, P. Sexton, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Structural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening

Arthur Christopoulos, Denise Wootten, Thomas Coudrat, 2017, PloS one.