M. Rowbottom

发表

Synthesis and structure-activity relationships of uracil derived human GnRH receptor antagonists: (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5.

Zhiqian Guo, Chen Chen, S. K. Sullivan, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists.

Zhiqian Guo, Q. Xie, Chen Chen, 2004, Bioorganic & medicinal chemistry letters.

Potent imidazole and triazole CB1 receptor antagonists related to SR141716.

Teresa Y. Phillips, Brock T Brown, B. Dyck, 2004, Bioorganic & medicinal chemistry letters.

Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor.

Zhiqian Guo, Chen Chen, J. Saunders, 2008, Journal of medicinal chemistry.

5-Aryluracils as potent GnRH antagonists-Characterization of atropisomers.

Zhiqian Guo, Chen Chen, Yun-fei Zhu, 2008, Bioorganic & medicinal chemistry letters.

Synthesis of vinyl epoxides via a three-component coupling

T. Gallagher, N. Mathews, M. Rowbottom, 1998 .

Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers.

Zhiqian Guo, Chen Chen, J. Saunders, 2005, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists.

Zhiqian Guo, Chen Chen, Yinghong Gao, 2004, Journal of medicinal chemistry.

Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity.

Zhiqian Guo, Chen Chen, Martin W Rowbottom, 2008, Bioorganic & medicinal chemistry letters.

3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterization.

N. Ling, Zhiqian Guo, Xin-jun Liu, 2005, Journal of medicinal chemistry.

Bis(aminopyrrolidine)-derived ureas (APUs) as potent MCH1 receptor antagonists.

John Saunders, Liren Zhao, Mingzhu Zhang, 2005, Bioorganic & medicinal chemistry letters.

CEP-32496: A Novel Orally Active BRAFV600E Inhibitor with Selective Cellular and In Vivo Antitumor Activity

Raffaella Faraoni, Darren E. Insko, P. Dobrzanski, 2012, Molecular Cancer Therapeutics.

Preclinical Development CEP-32496 : A Novel Orally Active BRAFV 600 E Inhibitor with Selective Cellular and In Vivo Antitumor Activity

Raffaella Faraoni, Darren E. Insko, P. Dobrzanski, 2012 .

Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2.

Troy D. Vickers, C. Heise, M. Kiankarimi, 2006, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of biarylcarboxamide bis-aminopyrrolidine urea derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1).

John Saunders, Liren Zhao, D. Provencal, 2005, Bioorganic & medicinal chemistry letters.

Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX.

Jilly F. Evans, C. King, J. Hutchinson, 2017, ACS medicinal chemistry letters.

Thienopyrimidinone bis-aminopyrrolidine ureas as potent melanin-concentrating hormone receptor-1 (MCH-R1) antagonists.

Mingzhu Zhang, Troy D. Vickers, B. Dyck, 2007, Bioorganic & medicinal chemistry letters.

Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E.

A. Ghose, Brian T. Campbell, Raffaella Faraoni, 2012, Journal of medicinal chemistry.

4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors.

Brian T. Campbell, Raffaella Faraoni, Andiliy G. Lai, 2011, Bioorganic & Medicinal Chemistry Letters.

Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2).

Jilly F. Evans, Andiliy G. Lai, D. Mackenna, 2017, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1.

Mingzhu Zhang, Troy D. Vickers, B. Dyck, 2006, Bioorganic & medicinal chemistry letters.

Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E.

A. Ghose, Brian T. Campbell, Raffaella Faraoni, 2012, Journal of medicinal chemistry.