K. Pawelczak

发表

Editorial: Targeting DNA repair and the DNA damage response: Beyond the standard PI3 kinase-like kinases

P. McHugh, J. Turchi, M. Weinfeld, 2022, Frontiers in Oncology.

OB-Folds and Genome Maintenance: Targeting Protein–DNA Interactions for Cancer Therapy

J. Turchi, J. Stewart, K. Pawelczak, 2021, Cancers.

Recent Advances in the Development of Non-PIKKs Targeting Small Molecule Inhibitors of DNA Double-Strand Break Repair

Navnath S. Gavande, J. Turchi, Deepti Pandey, 2022, Frontiers in Oncology.

DNA repair targeted therapy: The past or future of cancer treatment?

Navnath S. Gavande, Pamela S. VanderVere-Carozza, H. Hinshaw, 2016, Pharmacology & therapeutics.

Platinum-Induced Ubiquitination of Phosphorylated H2AX by RING1A Is Mediated by Replication Protein A in Ovarian Cancer

K. Nephew, H. O’Hagan, J. Turchi, 2020, Molecular Cancer Research.

Coordination of DNA-PK activation and nuclease processing of DNA termini in NHEJ.

J. Turchi, Sara M Bennett, K. Pawelczak, 2011, Antioxidants & redox signaling.

Determining molecular mechansims of DNA non-homologous end joining proteins

K. Pawelczak, 2010 .

Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK-dependent processing of DNA termini in NHEJ-catalyzed DSB repair.

J. Turchi, K. Pawelczak, 2010, DNA repair.

The Novel, Small-Molecule DNA Methylation Inhibitor SGI-110 as an Ovarian Cancer Chemosensitizer

D. Matei, K. Nephew, J. Turchi, 2014, Clinical Cancer Research.

ATM mediates repression of DNA end-degradation in an ATP-dependent manner.

Elias A. Rahal, J. Turchi, K. Dixon, 2008, DNA repair.

Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency.

S. Cantor, J. Turchi, J. Jonkers, 2021, Molecular cell.

Modulating DNA Repair Pathways to Improve Precision Genome Engineering.

Navnath S. Gavande, J. Turchi, K. Pawelczak, 2017, ACS chemical biology.

Ku–DNA binding inhibitors modulate the DNA damage response in response to DNA double-strand breaks

Navnath S. Gavande, J. Turchi, J. Dynlacht, 2022, NAR cancer.

Trait stacking via targeted genome editing.

Michael G Murray, Bryan Zeitler, Lakshmi Sastry-Dent, 2013, Plant biotechnology journal.

In Vivo Targeting Replication Protein A for Cancer Therapy

Navnath S. Gavande, S. Jalal, J. Turchi, 2022, Frontiers in Oncology.

Chemical exhaustion of RPA in cancer treatment

Navnath S. Gavande, S. Jalal, J. Turchi, 2020, bioRxiv.

Discovery and development of novel DNA-PK inhibitors by targeting the unique Ku–DNA interaction

Navnath S. Gavande, Pamela S. VanderVere-Carozza, C. Sears, 2020, bioRxiv.

Discovery and Development of Novel DNA-PK Inhibitors by Targeting the unique Ku-DNA Interaction

Navnath S. Gavande, Pamela S. VanderVere-Carozza, C. Sears, 2020, bioRxiv.

Abstract 4623: The novel, small molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer.

D. Matei, K. Nephew, J. Turchi, 2013 .

Structure-Guided Optimization of Replication Protein A (RPA)-DNA Interaction Inhibitors.

Navnath S. Gavande, J. Turchi, Tyler L. Vernon, 2020, ACS medicinal chemistry letters.

Differential activation of DNA-PK based on DNA strand orientation and sequence bias

J. Turchi, B. Andrews, K. Pawelczak, 2005, Nucleic acids research.

Multiple protein-protein interactions within the DNA-PK complex are mediated by the C-terminus of Ku 80.

J. Turchi, Derek S. Woods, Sara M Bennett, 2012, International journal of biochemistry and molecular biology.

A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining

K. S. Pawelczak, J. Turchi, K. Pawelczak, 2008, Nucleic acids research.

Design and Structure-Guided Development of Novel Inhibitors of the Xeroderma Pigmentosum Group A (XPA) Protein-DNA Interaction.

Navnath S. Gavande, J. Turchi, Tyler L. Vernon, 2017, Journal of medicinal chemistry.

Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency.

S. Cantor, J. Turchi, J. Jonkers, 2021, Molecular cell.

Chapter 5 – Targeting the nucleotide excision repair pathway for therapeutic applications

Navnath S. Gavande, Pamela S. VanderVere-Carozza, K. S. Pawelczak, 2016 .

DNA repair targeted therapy: The past or future of cancer treatment?

Navnath S. Gavande, H. Hinshaw, S. Jalal, 2016, Pharmacology & therapeutics.