Yubo Zhou

发表

Synthesis and Evaluation of 3‐(furo[2,3‐b]pyridin‐3‐yl)‐4‐(1H‐indol‐3‐yl)‐maleimides as Novel GSK‐3β Inhibitors and Anti‐Ischemic Agents

Luyong Zhang, Jian-rong Gao, Jia Li, 2015, Chemical biology & drug design.

Synthesis and biological evaluation of 3-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-4-(indol-3-yl)-maleimides as potent, selective GSK-3β inhibitors and neuroprotective agents.

Luyong Zhang, Jian-rong Gao, Jia Li, 2015, Bioorganic & medicinal chemistry.

Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on 'clicked' serine/threonine-monosaccharide hybrids.

Wei Zhang, Kaixian Chen, Yun Tang, 2011, Bioorganic & medicinal chemistry.

Synthesis and Evaluation of 3-(Indol-3-yl)-4-(Pyrazolo[3,4-c]Pyridazin-3-yl)-Maleimides as Potent Mutant Isocitrate Dehydrogenase-1 Inhibitors

Chunqi Hu, Jian-rong Gao, Lei Xu, 2021, Pharmaceutical Chemistry Journal.

Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors.

Jia Li, Tingjun Hou, Lei Xu, 2020, Bioorganic & medicinal chemistry letters.

Novel microtubule-targeted agent 6-chloro-4-(methoxyphenyl) coumarin induces G2-M arrest and apoptosis in HeLa cells

Yi-ming Ma, Yu-bo Zhou, Chuan-ming Xie, 2012, Acta Pharmacologica Sinica.

Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla.

Yu-bo Zhou, Yi Zang, Junmin Li, 2019, Phytochemistry.

Design, synthesis and biological evaluation of pyrazol-furan carboxamide analogues as novel Akt kinase inhibitors.

Bo Yang, Yongzhou Hu, Xiaodong Ma, 2016, European journal of medicinal chemistry.

Cephalotanins A-D, Four Norditerpenoids Represent Three Highly Rigid Carbon Skeletons from Cephalotaxus sinensis.

Yu-bo Zhou, Jia Li, J. Yue, 2016, Chemistry.

Selective Late-Stage Oxygenation with Ground-State Oxygen Based on Sulfides by Uranyl Photocatalysis.

Jia Li, Yiming Li, Danwen Sun, 2019, Angewandte Chemie.

Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-based Design.

Qiaojun He, Bo Yang, Yongzhou Hu, 2019, Journal of medicinal chemistry.

‘Click’ to bidentate bis-triazolyl sugar derivatives with promising biological and optical features

Jia Li, Yu-bo Zhou, Xiao‐Peng He, 2011 .

Design, synthesis and biological evaluation of novel tripeptidyl epoxyketone derivatives constructed from β-amino acid as proteasome inhibitors.

Jia Li, Tao Liu, Lei Xu, 2014, Bioorganic & medicinal chemistry.

Design, synthesis and evaluation of 7-azaindazolyl-indolyl-maleimides as glycogen synthase kinase-3β (GSK-3β) inhibitors.

Dan Lv, Jian-rong Gao, Jia Li, 2013, European journal of medicinal chemistry.

The anomeric mixture of some O-galactolipid derivatives is more toxic against cancer cells than either anomer alone.

Jia Li, Xiao‐Peng He, Guorong Chen, 2012, Bioorganic & medicinal chemistry letters.

Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors.

J. Yu, Xiaodong Ma, Xiaowu Dong, 2018, Journal of medicinal chemistry.

Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors.

Yu-bo Zhou, Jia Li, Shourong Liu, 2017, European journal of medicinal chemistry.

Rubiyunnanins C-H, cytotoxic cyclic hexapeptides from Rubia yunnanensis inhibiting nitric oxide production and NF-κB activation.

Jia Li, Yu-bo Zhou, G. Zeng, 2010, Bioorganic & medicinal chemistry.

Synthesis and Biological Evaluation of 3-Benzisoxazolyl-4-indolylmaleimides as Potent, Selective Inhibitors of Glycogen Synthase Kinase-3β

M. Li, Weisi Wang, Yu-bo Zhou, 2013, Molecules.

Hyperprins A and B, Two Complex Meroterpenoids from Hypericum przewalskii.

Y. Shao, Jia Li, A. Hou, 2020, Organic letters.

Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity.

Jun Yu Li, H. Aisa, Jun Li, 2021, Phytochemistry.

Synthesis and biological evaluation of piperamide analogues as HDAC inhibitors.

Yu-bo Zhou, Ming-bo Su, W. Lu, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of novel 4,5-bisindolyl-1,2,4-triazol-3-ones as glycogen synthase kinase-3β inhibitors and neuroprotective agents.

Jian-rong Gao, Jia Li, An-hui Gao, 2017, Pharmazie.

Design, synthesis and biological evaluation of bisthiazole-based trifluoromethyl ketone derivatives as potent HDAC inhibitors with improved cellular efficacy.

F. Nan, Jia Li, An-hui Gao, 2016, European journal of medicinal chemistry.

Diterpenes from the Hainan soft coral Lobophytum cristatum Tixier-Durivault.

Chang-Yun Wang, M. Gavagnin, E. Mollo, 2011, Journal of natural products.

Berberine combined with 2-deoxy-d-glucose synergistically enhances cancer cell proliferation inhibition via energy depletion and unfolded protein response disruption.

Yu-bo Zhou, Jia Li, An-hui Gao, 2013, Biochimica et biophysica acta.

Novel spirocyclic tranylcypromine derivatives as lysine-specific demethylase 1 (LSD1) inhibitors

Jia Li, Yu-bo Zhou, Ming-bo Su, 2018, RSC advances.

Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia.

Hong Liu, Chunpu Li, Jiang Wang, 2021, Journal of medicinal chemistry.

Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton's Tyrosine Kinase for the Treatment of Lymphoma.

Xiaowu Dong, Yizhe Wu, J. Che, 2022, Journal of medicinal chemistry.

3‐(7‐Azaindolyl)‐4‐indolylmaleimides as a novel class of mutant isocitrate dehydrogenase‐1 inhibitors: Design, synthesis, and biological evaluation

Jian-rong Gao, Jia Li, Lei Xu, 2018, Archiv der Pharmazie.

Structure-based rational design enables efficient discovery of a new selective and potent AKT PROTAC degrader.

Xiaowu Dong, Yizhe Wu, J. Che, 2022, European journal of medicinal chemistry.

New Steroids from the South China Sea Soft Coral Lobophytum sp.

Yucheng Gu, Jia Li, Yue‐Wei Guo, 2020, Chemistry & biodiversity.

Physalin B not only inhibits the ubiquitin-proteasome pathway but also induces incomplete autophagic response in human colon cancer cells in vitro

Li-Hong Hu, Yi-ming Ma, Yu-bo Zhou, 2015, Acta Pharmacologica Sinica.

Design, synthesis and biological evaluation of 4′-demethyl-4-deoxypodophyllotoxin derivatives as novel tubulin and histone deacetylase dual inhibitors

Jia Li, Yu-bo Zhou, Ming-bo Su, 2014 .

Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors.

Yan-fen Fang, Yi Zang, Wei Lu, 2015, European journal of medicinal chemistry.

Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors.

Yu-bo Zhou, R. Satheeshkumar, Jia Li, 2021, Bioorganic chemistry.

Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders.

Xiaomin Luo, Yu-bo Zhou, Jia Li, 2021, European journal of medicinal chemistry.

SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target

Gengfu Xiao, Xi Cheng, Lei-ke Zhang, 2020, Cell Research.

Identification of 2-Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c-KIT.

Xiaowu Dong, Jia Li, Tao Liu, 2022, Journal of medicinal chemistry.

Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies

Yongzhou Hu, Tao Liu, Lei Xu, 2021, Acta Pharmacologica Sinica.

Dual inhibition of CHK1/FLT3 enhances cytotoxicity and overcomes adaptive and acquired resistance in FLT3-ITD acute myeloid leukemia

Jianmin Yang, Jia Li, Yubing Han, 2022, Leukemia.

Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies.

Yongzhou Hu, Yu-bo Zhou, Jia Li, 2019, European journal of medicinal chemistry.

Design and synthesis of new lenalidomide analogs via Suzuki cross‐coupling reaction

Yu-bo Zhou, Wei Lu, Donghuai Xiao, 2020, Archiv der Pharmazie.

Benzo[c][1,2,5]thiadiazole derivatives: A new class of potent Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors.

Jingyu Zhu, Lei Xu, Li-xin Gao, 2017, Bioorganic & medicinal chemistry letters.

Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer.

Yu-bo Zhou, Minjia Tan, Ruimin Huang, 2021, Journal of medicinal chemistry.

Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s–PPARα axis signalling

W. Jia, Yu-bo Zhou, L. Rui, 2014, Nature Communications.

Disruption of the unfolded protein response (UPR) by lead compound selectively suppresses cancer cell growth.

J. Hou, Jia Li, An-hui Gao, 2015, Cancer letters.

Curcusone D, a novel ubiquitin-proteasome pathway inhibitor via ROS-induced DUB inhibition, is synergistic with bortezomib against multiple myeloma cell growth.

Yu-bo Zhou, Jia Li, Lei Xu, 2014, Biochimica et biophysica acta.

Tying up tranylcypromine: Novel selective histone lysine specific demethylase 1 (LSD1) inhibitors.

Yu-bo Zhou, Ming-bo Su, Jia Li, 2017, European journal of medicinal chemistry.

Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3Kα inhibitors via docking-based virtual screening.

Jia Li, R. Sheng, Gang Cheng, 2020, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 3-aryl-4-indolyl-maleimides as potent mutant isocitrate dehydrogenase-1 inhibitors.

Jian-rong Gao, Jia Li, Lei Xu, 2019, Bioorganic & medicinal chemistry.

Activation of unfolded protein response overcomes Ibrutinib resistance in diffuse large B-cell lymphoma

Lei Xu, An-hui Gao, Chunmei Xia, 2020, Acta pharmacologica Sinica.

Design, Synthesis, and Evaluation of 3‐Aryl‐4‐pyrrolyl‐maleimides as Glycogen Synthase Kinase‐3β Inhibitors

M. Li, Yongzhou Hu, Yu-bo Zhou, 2013, Archiv der Pharmazie.

Azoxystrobin, a mitochondrial complex III Qo site inhibitor, exerts beneficial metabolic effects in vivo and in vitro.

F. Nan, Haowen Jiang, An-hui Gao, 2014, Biochimica et biophysica acta.

A series of camptothecin prodrugs exhibit HDAC inhibition activity.

Yu-bo Zhou, Wei Lu, Ming-bo Su, 2018, Bioorganic & medicinal chemistry.

Design, Synthesis, and In Vitro Evaluation of Benzofuro[3,2-c]Quinoline Derivatives as Potential Antileukemia Agents

Jia Li, Jie Tang, D. Xing, 2020, Molecules.

Novel thieno[2,3-b]quinoline-procaine hybrid molecules: A new class of allosteric SHP-1 activators evolved from PTP1B inhibitors

Tingjun Hou, Jia Li, Qianwen Mu, 2022, Chinese Chemical Letters.

Design, Synthesis, and Biological Evaluation of HDAC Degraders with CRBN E3 Ligase Ligands

Yu-bo Zhou, Yingxin Lu, Danwen Sun, 2021, Molecules.

Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors.

F. Gao, Hong Liu, Chunpu Li, 2022, Journal of medicinal chemistry.

Divalent tranylcypromine derivative as lysine-specific demethylase 1 inhibitor

Tongchao Liu, Yu-bo Zhou, B. Xiong, 2021, Medicinal Chemistry Research.

Design, synthesis and biological evaluation of thioether-containing lenalidomide and pomalidomide derivatives with anti-multiple myeloma activity.

Jia Li, Yiming Li, Yu-bo Zhou, 2021, European journal of medicinal chemistry.

A novel GSK-3β inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway

Yu-bo Zhou, Jia Li, Jian-rong Gao, 2016, Acta Pharmacologica Sinica.

Triazine-Based Covalent DNA-Encoded Libraries for Discovery of Covalent Inhibitors of Target Proteins.

Yu-bo Zhou, Jia Li, Jiaxiang Liu, 2022, ACS medicinal chemistry letters.

A novel GSK-3β inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway

Jian-rong Gao, Jia Li, Lei Xu, 2016, Acta Pharmacologica Sinica.

Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors.

Jia Li, Tao Liu, Lei Xu, 2019, European journal of medicinal chemistry.

Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles.

Yongzhou Hu, Xiaowu Dong, J. Che, 2019, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of BRD4 degraders.

Y. Shao, Yi Zang, Danwen Sun, 2022, Bioorganic & medicinal chemistry.

Design, Synthesis and Biological Evaluation of Peptidyl Epoxyketone Proteasome Inhibitors Composed of β‐amino Acids

Jia Li, Yongzhou Hu, Xiaodong Ma, 2014, Chemical biology & drug design.

Novel CHOP activator LGH00168 induces necroptosis in A549 human lung cancer cells via ROS-mediated ER stress and NF-κB inhibition

Qiao-jun He, Yi-ming Ma, Jia Li, 2016, Acta Pharmacologica Sinica.

Targeting C/EBPα overcomes primary resistance and improves the efficacy of FLT3 inhibitors in acute myeloid leukaemia

Jianmin Yang, Tao Wang, Minmin Liu, 2023, Nature Communications.

Involvement of transcription factor XBP1s in the resistance of HDAC6 inhibitor Tubastatin A to superoxidation via acetylation-mediated proteasomal degradation.

Yu-bo Zhou, Yi Zang, Jia Li, 2014, Biochemical and biophysical research communications.

Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells.

Huazhou Ying, Xiaowu Dong, J. Che, 2020, European journal of medicinal chemistry.

Novel Nitric Oxide Donors of Phenylsulfonylfuroxan and 3-Benzyl Coumarin Derivatives as Potent Antitumor Agents.

Yu-bo Zhou, Jia Li, Ke Wang, 2018, ACS medicinal chemistry letters.

Characterization of a novel curcumin analog P1 as potent inhibitor of the NF-κB signaling pathway with distinct mechanisms

Yu-bo Zhou, Jia Li, Yan-min Peng, 2013, Acta Pharmacologica Sinica.

Discovery of Novel N-(5-(Pyridin-3-yl)-1H-indazol-3-yl)benzamide Derivatives as Potent Cyclin-Dependent Kinase 7 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease.

Tongchao Liu, Yu-bo Zhou, B. Xiong, 2022, Journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of 2‐Aminothiazole Derivatives as Novel Checkpoint Kinase 1 (CHK1) Inhibitors

T. Liu, Minjie Deng, Jia Li, 2023, ChemMedChem.

Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment.

Yu-bo Zhou, Jia Li, Qian Yu, 2022, European journal of medicinal chemistry.

Exploration of novel four-membered-heterocycle constructed peptidyl proteasome inhibitors with improved metabolic stability for cancer treatment.

G. Wei, Jia Li, Li-xin Gao, 2023, Bioorganic chemistry.

Design, synthesis and biological evaluation of thienopyridinones as Chk1 inhibitors.

Xiaodong Ma, Peng Peng, Tao Liu, 2014, Bioorganic & medicinal chemistry.

Optimization of piperidine constructed peptidyl derivatives as proteasome inhibitors.

Yu-bo Zhou, Jia Li, Lei Xu, 2020, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of the thioether-containing lenalidomide analogs with anti-proliferative activities.

Yu-bo Zhou, Wei Lu, Donghuai Xiao, 2019, European journal of medicinal chemistry.

Discovery of novel indoleaminopyrimidine NIK inhibitors based on molecular docking-based support vector regression (SVR) model

Jia Li, Huazhou Ying, Xiaowu Dong, 2019, Chemical Physics Letters.

The development and benefits of metformin in various diseases

Yi Zang, Haowen Jiang, Yongmei Zhang, 2023, Frontiers of Medicine.

Design, synthesis, and biological evaluation of novel phenol ether derivatives as non-covalent proteasome inhibitors.

Jia Li, Tao Liu, Lei Xu, 2019, European journal of medicinal chemistry.

5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma.

M. Geng, Hong Liu, Chunpu Li, 2021, European journal of medicinal chemistry.

Synthesis of 2-ethoxycarbonylthieno[2,3-b]quinolines in biomass-derived solvent γ-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B

Yu-bo Zhou, R. Satheeshkumar, Jia Li, 2021, RSC advances.

Polyprenylated acylphloroglucinol meroterpenoids with PTP1B inhibition from Hypericum forrestii.

Jia Li, A. Hou, Chun Lei, 2021, Fitoterapia.

Selective Late‐Stage Oxygenation of Sulfides with Ground‐State Oxygen by Uranyl Photocatalysis

Danwen Sun, Jia Li, An-hui Gao, 2019, Angewandte Chemie.

Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor.

Tongchao Liu, Yabing Chen, B. Xiong, 2019, Bioorganic & medicinal chemistry letters.

Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition

Yu-bo Zhou, Jia Li, Lei Xu, 2022, Acta Pharmacologica Sinica.

Design, synthesis and biological evaluation of novel non-covalent piperidine-containing peptidyl proteasome inhibitors.

Jia Li, Yidan Shao, Shourong Liu, 2016, Bioorganic & medicinal chemistry.

Synthesis and Biological Evaluation of 3-Amino-4,4-Dimethyl Lithocholic Acid Derivatives as Novel, Selective, and Cellularly Active Allosteric SHP1 Activators

Jia Li, Jie Tang, Li-xin Gao, 2023, Molecules.

Discovery of a Potent and Selective Degrader for USP7.

Jia Li, Bing Zhou, Ya-xi Yang, 2022, Angewandte Chemie.

Identification of new NIK inhibitors by discriminatory analysis‐based molecular docking and biological evaluation

Xiaowu Dong, N. Lin, Jia Li, 2019, Archiv der Pharmazie.

Two New Cytotoxic Maytansinoids Targeting Tubulin from Trewia nudiflora

Yu-bo Zhou, Jia Li, A. Hou, 2021, Planta Medica.

Discovery of a potent and selective NF-κB-inducing kinase (NIK) inhibitor that has anti-inflammatory effects in vitro and in vivo.

H. Zhang, C. Luo, Yu-bo Zhou, 2020, Journal of medicinal chemistry.

Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy.

Yujun Zhao, Shiyan Zhang, Ziqin Yan, 2023, Journal of medicinal chemistry.

Identification of novel inhibitors of Aurora A with a 3-(pyrrolopyridin-2-yl)indazole scaffold.

Xiaodong Ma, Tao Liu, Lei Xu, 2015, Bioorganic & medicinal chemistry.

Discovery of 2-Aminopyrimidine Derivatives as Potent Dual FLT3/CHK1 Inhibitors with Significantly Reduced hERG Inhibitory Activities.

T. Liu, Jia Li, Peipei Wang, 2023, Journal of medicinal chemistry.

Convenient preparation of pinometostat and related 5′-deoxy-5′-amino adenosine derivatives as well as their activity against DOT1L

Tongchao Liu, Jia Li, Yu-bo Zhou, 2018 .

Preparation of 5'-deoxy-5'-amino-5'-C-methyl adenosine derivatives and their activity against DOT1L.

Tongchao Liu, Yu-bo Zhou, B. Xiong, 2017, Bioorganic & medicinal chemistry letters.

Functions and inhibitors of CHK1 in cancer therapy

Kailong Jiang, Yubo Zhou, Minjie Deng, 2024, Medicine in Drug Discovery.