J. Trembley

发表

Bioassay-guided isolation and characterization of lead antimicrobial compounds from Acacia hydaspica plant extract

M. Shabbir, Khushbukhat Khan, Tayyaba Afsar, 2022, AMB Express.

Analyzing PKC Gamma (+ 19,506 A/G) polymorphism as a promising genetic marker for HCV-induced hepatocellular carcinoma

M. Shabbir, Khushbukhat Khan, N. M. Ashraf, 2022, Biomarker Research.

Posttranscriptional regulation of cyclin B messenger RNA expression in the regenerating rat liver.

C. Steer, B. Kren, J. H. Trembley, 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

CDK11 Complexes Promote Pre-mRNA Splicing*

A. Mayeda, V. Kidd, J. Lahti, 2003, The Journal of Biological Chemistry.

Tenfibgen-DMAT Nanocapsule Delivers CK2 Inhibitor DMAT to Prostate Cancer Xenograft Tumors Causing Inhibition of Cell Proliferation.

G. Niehans, R. Vogel, G. Unger, 2014, Molecular and cellular pharmacology.

PITSLRE p110 Protein Kinases Associate with Transcription Complexes and Affect Their Activity*

C. Slaughter, V. Kidd, J. Lahti, 2002, The Journal of Biological Chemistry.

The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinase in vivo.

P. Loyer, J. H. Trembley, V. Kidd, 1998, Journal of cell science.

Roles of CDK/Cyclin complexes in transcription and pre-mRNA splicing: Cyclins L and CDK11 at the cross-roads of cell cycle and regulation of gene expression.

P. Loyer, J. H. Trembley, J. Trembley, 2020, Seminars in cell & developmental biology.

Characterization of Cyclin L1 and L2 Interactions with CDK11 and Splicing Factors

P. Loyer, A. Corlu, V. Kidd, 2008, Journal of Biological Chemistry.

Cyclin dependent kinase 11 in RNA transcription and splicing.

P. Loyer, V. Kidd, Tongyuan Li, 2004, Progress in nucleic acid research and molecular biology.

Protein kinase CK2 – diverse roles in cancer cell biology and therapeutic promise

B. Kren, J. H. Trembley, K. Ahmed, 2022, Molecular and Cellular Biochemistry.

CK2 Pro-Survival Role in Prostate Cancer Is Mediated via Maintenance and Promotion of Androgen Receptor and NFκB p65 Expression

B. Kren, K. Ahmed, Yingming Li, 2019, Pharmaceuticals.

CK2: A Global Regulator of Cell Death

B. Kren, K. Ahmed, Fatima Qaiser, 2015 .

Determining KLF14 tertiary structure and diagnostic significance in brain cancer progression

J. H. Trembley, M. Shabbir, Khushbukhat Khan, 2022, Scientific Reports.

Identification of high protein kinase CK2α in HPV(+) oropharyngeal squamous cell carcinoma and correlation with clinical outcomes

B. Kren, K. Ahmed, A. Gravely, 2021, PeerJ.

CX-4945 and siRNA-Mediated Knockdown of CK2 Improves Cisplatin Response in HPV(+) and HPV(−) HNSCC Cell Lines

B. Kren, J. H. Trembley, K. Ahmed, 2021, Biomedicines.

Role of CDK/cyclin complexes in transcription and RNA splicing.

P. Loyer, V. Kidd, J. Lahti, 2005, Cellular signalling.

Activation of Pre-mRNA Splicing by Human RNPS1 Is Regulated by CK2 Phosphorylation

E. Sakashita, H. Endo, Hitoshi Suzuki, 2005, Molecular and Cellular Biology.

Mechanism and Efficacy of Sub–50-nm Tenfibgen Nanocapsules for Cancer Cell–Directed Delivery of Anti-CK2 RNAi to Primary and Metastatic Squamous Cell Carcinoma

T. Kimbrough, F. Ondrey, R. Vogel, 2014, Molecular Cancer Therapeutics.

CDK11 Loss Induces Cell Cycle Dysfunction and Death of BRAF and NRAS Melanoma Cells

R. Vogel, R. Ahmed, B. Kren, 2019, Pharmaceuticals.

The RNA Binding Motif Protein 15B (RBM15B/OTT3) Is a Functional Competitor of Serine-Arginine (SR) Proteins and Antagonizes the Positive Effect of the CDK11p110-Cyclin L2α Complex on Splicing*

P. Loyer, T. Montier, V. Kidd, 2010, The Journal of Biological Chemistry.

Investigation of UTR Variants by Computational Approaches Reveal Their Functional Significance in PRKCI Gene Regulation

M. Shabbir, Khushbukhat Khan, Tayyaba Afsar, 2023, Genes.

CK2 Suppression of Apoptosis and Its Implication in Cancer Biology and Therapy

G. Unger, B. Kren, J. H. Trembley, 2013 .

Systemic administration of antisense oligonucleotides simultaneously targeting CK2α and α′ subunits reduces orthotopic xenograft prostate tumors in mice

G. Unger, B. Kren, V. Korman, 2011, Molecular and Cellular Biochemistry.

Emergence of protein kinase CK2 as a key target in cancer therapy

C. Van Waes, Zhong Chen, G. Unger, 2010, BioFactors.

CK2: A key player in cancer biology

G. Unger, J. H. Trembley, K. Ahmed, 2009 .

Protein Kinase CK2 in Health and Disease

G. Unger, J. H. Trembley, K. Ahmed, 2009, Cellular and Molecular Life Sciences.

Genomic organization and promoter characterization of the rat cyclin B1 gene.

B. Kren, J. H. Trembley, C. Rodrigues, 2000, Gene.

Examination of CK2α and NF-κB p65 expression in human benign prostatic hyperplasia and prostate cancer tissues

T. Rector, K. Ahmed, B. Murtaza, 2016, Molecular and Cellular Biochemistry.

CK2 targeted RNAi therapeutic delivered via malignant cell-directed tenfibgen nanocapsule: dose and molecular mechanisms of response in xenograft prostate tumors

G. Niehans, R. Vogel, G. Unger, 2016, Oncotarget.

CK2 Molecular Targeting—Tumor Cell-Specific Delivery of RNAi in Various Models of Cancer

R. Vogel, G. Unger, B. Kren, 2017, Pharmaceuticals.

Modulation of apoptosis-associated genes bcl-2, bcl-x, and bax during rat liver regeneration.

John Calvin Reed, S. Krajewski, T. Behrens, 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Nanoencapsulated anti-CK2 small molecule drug or siRNA specifically targets malignant cancer but not benign cells.

L. Pinna, G. Unger, B. Kren, 2012, Cancer letters.

Association of CTLA-4 and IL-4 polymorphisms in viral induced liver cancer

J. H. Trembley, M. Shabbir, Khushbukhat Khan, 2022, BMC cancer.

Growth inhibition and apoptosis in cancer cells induced by polyphenolic compounds of Acacia hydaspica: Involvement of multiple signal transduction pathways

K. Ahmed, C. Salomon, Muhammad Rashid Khan, 2016, Scientific Reports.

Pathogenicity of PKCγ Genetic Variants—Possible Function as a Non-Invasive Diagnostic Biomarker in Ovarian Cancer

M. Shabbir, Khushbukhat Khan, Tayyaba Afsar, 2023, Genes.

Cyclins and gap junctions in liver growth and repair

C. Steer, B. Kren, J. H. Trembley, 1998 .

Whole-body inhalation of nano-sized carbon black: a surrogate model of military burn pit exposure

W. Goldsmith, J. H. Trembley, T. Nurkiewicz, 2022, BMC research notes.

Improving Health Care for Veterans With Gulf War Illness.

J. H. Trembley, Ronald R Bach, Nicole Baldwin, 2019, Federal practitioner : for the health care professionals of the VA, DoD, and PHS.

Differential regulation of cyclin B1 RNA and protein expression during hepatocyte growth in vivo.

B. Kren, C. Steer, J. Trembley, 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Evaluation of protein kinase CK2 as a therapeutic target for squamous cell carcinoma of cats.

J. Modiano, M. G. O’Sullivan, G. Unger, 2017, American journal of veterinary research.

Protein kinase CK2 impact on intracellular calcium homeostasis in prostate cancer

B. Kren, J. H. Trembley, K. Ahmed, 2020, Molecular and Cellular Biochemistry.

Sulindac acetohydrazide derivative attenuates against cisplatin induced organ damage by modulation of antioxidant and inflammatory signaling pathways

M. Abulmeaty, J. H. Trembley, N. Bibi, 2022, Scientific Reports.

Alterations in mRNA stability during rat liver regeneration.

B. Kren, C. Steer, J. Trembley, 1996, The American journal of physiology.

Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy

R. Vogel, G. Unger, B. Kren, 2015, Breast Cancer Research.

Tenfibgen Ligand Nanoencapsulation Delivers Bi-Functional Anti-CK2 RNAi Oligomer to Key Sites for Prostate Cancer Targeting Using Human Xenograft Tumors in Mice

R. Vogel, G. Unger, B. Kren, 2014, PloS one.

Casein Kinase 2 Interacts with Cyclin-dependent Kinase 11 (CDK11) in Vivo and Phosphorylates Both the RNA Polymerase II Carboxyl-terminal Domain and CDK11 in Vitro *

C. Slaughter, V. Kidd, J. Lahti, 2003, The Journal of Biological Chemistry.

Elucidating the role of missense SNP of protein kinase C epsilon in HCV-induced hepatocellular carcinoma

M. Shabbir, Khushbukhat Khan, N. M. Ashraf, 2023, BMC Cancer.

Targeting CK2 for Cancer Therapy Using a Nanomedicine Approach

G. Unger, B. Kren, K. Ahmed, 2015 .

Therapeutic Targeting of Protein Kinase CK2 Gene Expression in Feline Oral Squamous Cell Carcinoma: A Naturally Occurring Large-Animal Model of Head and Neck Cancer.

J. Modiano, M. G. O’Sullivan, G. Unger, 2017, Human gene therapy. Clinical development.

Abbreviations ALT : Alanine aminotransferase AST : Aspartate transaminase BUN : Blood urea nitrogen CPK : Creatine phosphokinase CR : Complete response DLT : Dose limiting toxicity FOSCC : Feline oral squamous cell carcinoma

J. Modiano, M. G. O’Sullivan, G. Unger, 2017 .

Protein Kinase CK2 Inhibition Induces Cell Death via Early Impact on Mitochondrial Function

B. Kren, J. H. Trembley, K. Ahmed, 2014, Journal of cellular biochemistry.

Protein kinase CK2 impact on intracellular calcium homeostasis in prostate cancer

B. Kren, K. Ahmed, A. Naveed, 2020, Molecular and Cellular Biochemistry.

Gulf War Illness-associated increases in blood levels of interleukin 6 and C-reactive protein: biomarker evidence of inflammation

J. H. Trembley, Ronald R Bach, T. Butterick, 2019, BMC Research Notes.

Whole-body inhalation of nano-sized carbon black: a surrogate model of military burn pit exposure

W. Goldsmith, T. Nurkiewicz, Salik Hussain, 2022, BMC research notes.

Molecular Regulation of Liver Regeneration a

C. Steer, B. Kren, J. H. Trembley, 1997, Annals of the New York Academy of Sciences.

MATERIALS AND METHODS

P. Loyer, T. Montier, J. H. Trembley, 2010 .

Exploring the prognostic significance of PKCε variants in cervical cancer

M. Shabbir, Khushbukhat Khan, Tayyaba Afsar, 2023, BMC Cancer.

Investigating pathogenic SNP of PKCι in HCV-induced hepatocellular carcinoma

M. Shabbir, Khushbukhat Khan, Tayyaba Afsar, 2023, Scientific reports.

The prevalence of post-traumatic stress disorder among emergency medical services personnel in Saudi Red Crescent Authority, Riyadh, Saudi Arabia

S. Razak, J. Trembley, Ali A. Abusharha, 2024, Frontiers in psychiatry.

Examination of CK2α and NF-κB p65 expression in human benign prostatic hyperplasia and prostate cancer tissues

T. Rector, K. Ahmed, B. Murtaza, 2016, Molecular and Cellular Biochemistry.

Cross talk of tumor protein D52 (TPD52) with KLF9, PKCε, and MicroRNA 223 in ovarian cancer

M. Shabbir, Mehak Rafiq, Khushbukhat Khan, 2023, Journal of Ovarian Research.

Tenfibgen Ligand Nanoencapsulation Delivers Bi-Functional Anti-CK2 RNAi Oligomer to Key Sites for Prostate Cancer Targeting Using Human Xenograft Tumors in Mice

R. Vogel, G. Unger, B. Kren, 2014, PloS one.

Gross Hematuria and Lower Urinary Tract Symptoms Associated With Military Burn Pits Exposures in US Veterans Deployed to Iraq and Afghanistan

P. Barach, P. Ginex, A. Gravely, 2023, Journal of occupational and environmental medicine.

Genetic polymorphism in untranslated regions of PRKCZ influences mRNA structure, stability and binding sites

M. Shabbir, Khushbukhat Khan, Tayyaba Afsar, 2024, BMC cancer.

Possible prognostic impact of PKCι genetic variants in prostate cancer

Afifa Marium, M. Shabbir, Khushbukhat Khan, 2024, Cancer cell international.